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  • Wiley  (3)
  • Andreis, Samantha  (3)
  • 1
    Online Resource
    Online Resource
    Epstein–Barr and cytomegalovirus DNA salivary shedding correlate with long‐term plasma HIV RNA detection in HIV‐infected men who have sex with men
    Wiley ; 2016
    In:  Journal of Medical Virology Vol. 88, No. 7 ( 2016-07), p. 1211-1221
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    In: Journal of Medical Virology, Wiley, Vol. 88, No. 7 ( 2016-07), p. 1211-1221
    Abstract: The aim of the study was to evaluate cytomegalovirus (CMV) and Epstein–Barr virus (EBV) DNA salivary shedding in HIV‐positive men who have sex with men (MSM) and to determine whether viro‐immunological parameters and long‐term (24 months) plasma HIV RNA (pHIV) detection may predict herpesviruses replication. A total of 193 HIV‐positive MSM were consecutively recruited (mean CD4+ cell count 607 cells/mm 3 and mean nadir value 333 cells/mm 3 ); pHIV was analyzed for 24 months prior to saliva sampling: patients were categorized as successfully suppressed (SS) and not suppressed (NS). The EBV viral load was categorized as high viral load (HVL), intermediate (IVL), or low (LVL), CMV DNA as positive or negative. NS patients experienced both herpesviruses detectability more frequently respect to SS patients ( P  = 0.034); conversely, no salivary shedding was more frequent in SS patients ( P  = 0.014). HVL EBV was more frequent in NS patients than in SS subjects ( P  = 0.038 for isolated EBV detection and P  = 0.001 when CMV shedding was associated). NS subjects with HVL EBV had a median pHIV of 43,820 copies/ml, significantly higher respect to IVL and LVL patients ( P  = 0.027 and P  = 0.0005, respectively). CMV shedding was mostly associated to EBV shedding. NS patients showed a significantly higher frequency of saliva HVL EBV detection compared to SS patients; moreover, NS patients with HVL EBV had a higher pHIV respect to those with IVL and LVL shedding. Our results suggest that a successful pHIV suppression could reduce the burden of salivary EBV replication and likely the risk of herpesviruses‐related cancers. J. Med. Virol. 88:1211–1221, 2016 . © 2015 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v88.7
    DOI: 10.1002/jmv.24441
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 2
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    Structural‐equation‐modelling of the tropism impact on achieving viral suppression within six months in naïve HIV patients
    Wiley ; 2014
    In:  Journal of the International AIDS Society Vol. 17, No. 4S3 ( 2014-11)
    Details
    In: Journal of the International AIDS Society, Wiley, Vol. 17, No. 4S3 ( 2014-11)
    Abstract: Aim of the study was to evaluate the relevance of baseline (BL) plasma tropism of HIV on the achievement of a viral suppression within six months of antiviral therapy (ARV) in naïve patients by a structural‐equation‐modelling. Materials and Methods Two‐hundred and twenty‐seven patients were enrolled; viral tropism on plasma was determined at baseline (BL) by sequencing and interpretation by genotopheno algorithm. Booster atazanavir or lopinavir, or efavirenz or nevirapine were used, in combination with either abacavir/lamivudine or tenofovir‐emtricitabine. Results X4‐tropism correlate negatively with CD4 cell count at BL and follow‐up (FU), and CD4 correlate negatively with BL‐plasma viremia (PLV). BL‐PLV correlate positively with FU‐PLV. We have developed the hypothesis that the variables BL‐CD4 and BL‐PLV represent a mediators chain among X4‐tropism and outcome of plasma viraemia at six months. This model, after structural‐equation‐modelling (SEM, Stata13), is shown in Figure 1 . The indirect effect of X4‐tropism on Fup‐PLV is significant (p 〈 0.01) but about 10 fold lower than the direct effect by BL‐PLV. X4‐tropism also has a direct negative effect on BL‐CD4 (p 〈 0.001) and an indirect positive effect on BL‐PLV (p 〈 0.001), irrespective of the drug regimen. Path model explaining direct and mediated effects of “tro (tropism),” “gender,” “age,” “cd0 (BL‐CD4)” and “lrna0 (BL‐PLV)” on the final outcome (“lrna1‐Fup‐PLV),” where “tro,” “gender,” and “age” are exogenous, cd0 and lrna0 are endogenous (mediators). Numbers on the arrows indicate direct effects. Circles indicate residuals related to endogenous/dependent variables; numbers near to circles are the corresponding variances. Conclusions This model shows the relevance of BL‐tropism on the outcome of plasma viraemia in naïve patients after six months of therapy, irrespective of drug regimen used.
    Type of Medium: Online Resource
    ISSN: 1758-2652 , 1758-2652
    URL: Article
    DOI: 10.7448/IAS.17.4.19679
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2467110-1
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  • 3
    Online Resource
    Online Resource
    KSHV DNA viremia correlates with low CD4+ cell count in Italian Males at the time of diagnosis of HIV infection
    Wiley ; 2011
    In:  Journal of Medical Virology Vol. 83, No. 3 ( 2011-03), p. 384-390
    Details
    In: Journal of Medical Virology, Wiley, Vol. 83, No. 3 ( 2011-03), p. 384-390
    Abstract: To evaluate the relevance and the virological and immunological markers of Kaposi sarcoma herpesvirus 8 (KSHV) viremia in Italian male patients at the time of diagnosis of infection with HIV‐1, 481 men infected with HIV were recruited consecutively. The presence of KSHV DNA was evaluated in peripheral blood mononuclear cells (PBMCs) and in plasma and correlated with demographic and viro‐immunological parameters. Seventy‐four patients had KSHV DNA detected in PBMCs. By univariate analysis, the presence of KSHV DNA was associated significantly with unprotected homosexual relationships ( P = 0.003) and it was significantly higher in patients with CD4+ cell 〈 350 ( P = 0.025). By multivariate analysis, homosexual relationships were associated independently with KSHV DNA in PBMCs (OR: 3.25; 95% CI: 1.1–9.7; P = 0.035). Among the 74 patients with KSHV DNA detected in PBMCs, plasma samples from 60 were analyzed and 33 were positive for KSHV DNA. The CD4+ cell counts and percentages were significantly lower in patients with KSHV DNA in both PBMCs and plasma as compared to patients with only KSHV DNA in PBMCs ( P = 0.006 and P = 0.019, respectively). Among the patients with KSHV DNA detected in PBMCs, all 13 patients with CD4+ cells count 〈 200 had detectable levels of KSHV in their plasma. By multivariate analysis adjusted for the epidemiologic and virological parameters, low CD4+ cell count was the only independent variable associated with the presence of KSHV DNA in plasma (OR, 0.001; 95% CI: 〈 0.001–0.001; P = 0.03). In HIV‐positive antiretroviral therapy‐naïve males, KSHV active replication as detected by KSHV DNA in plasma was associated significantly with low CD4+ cell count. J. Med. Virol. 83:384–390, 2011. © 2011 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v83.3
    DOI: 10.1002/jmv.21987
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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