In:
International Journal of Cancer, Wiley, Vol. 145, No. 9 ( 2019-11), p. 2407-2417
Abstract:
What's new? Genetic alterations are the starting point of numerous changes in clinical and pathologic features (phenotypes) of individual cancers; however, their interrelationships in gastric cancers (GC) remain unclear. In this study correlating clinical, pathologic, and genomics data in 330 GC patients, high tumor mutation burden (TMB) accounted for 11% of cases and was significantly more frequent in intestinal‐type GC, tumors with higher host immune response, earlier cancer stage, and favorable prognosis. PD‐L1 expression was significantly associated with MSI‐H, higher host immune response, and high TMB. The results provide a better understanding of GC and serve as a baseline for precision oncology.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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