In:
Journal of Orthopaedic Research, Wiley, Vol. 31, No. 2 ( 2013-02), p. 173-182
Abstract:
Some tissues from metal‐on‐metal (MoM) hip arthroplasty revisions have shown evidence of adaptive‐immune reactivity (i.e., excessive peri‐implant lymphocyte infiltration/activation). We hypothesized that, prior to symptoms, some people with MoM hip arthroplasty will develop quantifiable metal‐induced lymphocyte reactivity responses related to peripheral metal ion levels. We tested three cohorts (Group 1: n = 21 prospective longitudinal MoM hip arthroplasty; Group 2: n = 17 retrospective MoM hip arthroplasty; and Group 3: n = 20 controls without implants). We compared implant position, metal‐ion release, and immuno‐reactivity. MoM cohorts had elevated ( p 〈 0.01) amounts of serum Co and Cr compared to controls as early as 3 months post‐op (Group 1:1.2 ppb Co, 1.5 ppb Cr; Group 2: 3.4 ppb Co, 5.4 ppb Cr; Group 3: 0.01 ppb Co, 0.1 ppb Cr). However, only after 1–4 years post‐op did 56% of Group 1 develop metal‐reactivity (vs. 5% pre‐op, metal‐LTT, SI 〉 2), compared with 76% of Group 2, and 15% of Group 3 controls (patch testing was a poor diagnostic indicator with only 1/21 Group 1 positive). Higher cup‐abduction angles (50° vs. 40°) in Group 1 were associated with higher serum Cr ( p 〈 0.07). However, sub‐optimal cup‐anteversion angles (9° vs. 20°) had higher serum Co ( p 〈 0.08). Serum Cr and Co were significantly elevated in reactive versus non‐reactive Group‐1 participants ( p 〈 0.04). CD4+CD69+ T‐helper lymphocytes (but not CD8+) and IL‐1β, IL‐12, and IL‐6 cytokines were all significantly elevated in metal‐reactive versus non‐reactive Group 1 participants. Our results showed that lymphocyte reactivity to metals can develop within the first 1–4 years after MoM arthroplasty in asymptomatic patients and lags increases in metal ion levels. This increased metal reactivity was more prevalent in those individuals with extreme cup angles and higher amounts of circulating metal. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 173–182, 2013
Type of Medium:
Online Resource
ISSN:
0736-0266
,
1554-527X
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2050452-4
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