In:
Journal of the Science of Food and Agriculture, Wiley, Vol. 97, No. 8 ( 2017-06), p. 2664-2670
Abstract:
This study was designed to investigate the effects of immature carob pod aqueous extract ( ICPAE ) on intestinal glucose absorption in vitro and in vivo using an oral glucose tolerance test ( OGTT ) as well as the potential antidiabetic effect in alloxan‐induced diabetic rats. OGTT was carried by administration of glucose (2 g kg −1 , p.o.) and after treatment with extract (50, 100 and 200 mg kg −1 body weight). Diabetes was induced by single intraperitoneal injection of alloxan (150 mg kg −1 ). However, the extracts at various doses or glibenclamide ( GLB , 10 mg kg −1 body weight) were given by oral administration for 2 weeks. RESULTS ICPAE (50–2000 µg mL −1 ) exerted dose‐dependent reduction of sodium‐dependent glucose transport across isolated mice jejunum and the maximal inhibition exceeded 50%.The ICPAE treatment improved glucose tolerance. More importantly, ICPAE at various doses showed a significant reduction in blood glucose and biochemical profiles in diabetic rats. CONCLUSION Our findings confirm that the degree of maturity of carob characterized by a different phytochemical composition may be responsible for these actions. Therefore, these compounds may be used as a food supplement in hyperglycemia and diabetes treatments. © 2016 Society of Chemical Industry
Type of Medium:
Online Resource
ISSN:
0022-5142
,
1097-0010
DOI:
10.1002/jsfa.2017.97.issue-8
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2001807-1
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