In:
Molecular Oncology, Wiley, Vol. 9, No. 1 ( 2015-01), p. 236-248
Kurzfassung:
p53/MDM2 ratio is deregulated in schwannoma increasing tumour growth and survival. p53 is regulated by merlin involving FAK, AKT and MDM2. Combined merlin and Nutlin‐3 normalise p53 reducing schwannoma growth and survival. Nutlin‐3 increases p53 stability and is a good drug candidate for schwannoma treatment.
Materialart:
Online-Ressource
ISSN:
1574-7891
,
1878-0261
DOI:
10.1016/j.molonc.2014.08.005
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
2322586-5
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