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  • Royal College of Psychiatrists  (12)
  • Ames, David  (12)
  • 1
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 1992
    In:  Psychiatric Bulletin Vol. 16, No. 9 ( 1992-09), p. 552-554
    In: Psychiatric Bulletin, Royal College of Psychiatrists, Vol. 16, No. 9 ( 1992-09), p. 552-554
    Abstract: Australia is a unique, geologically ancient island continent. Its flora and fauna are unlike those found anywhere else and the same may be said of its people, politics and health services. The population of 17.3 millions represents a multicultural mix, with an anglo-celtic core conflated by sustained post-war immigration from southern Europe, Turkey, southeast Asia and south America. One in five current Australians was born elsewhere, one in ten comes from a non-English speaking background, and a quarter of those born here have a parent who was born overseas. Aboriginals and Torres Strait Islanders form 1.4% of the total population. They have third world mortality figures but die of first world diseases, their life expectancy being 20 years less than that of other Australians. Two hundred and four years after what they see as the British invasion, their standard of living lags far behind all other socio-cultural groups in the country. Most members of the Aboriginal community do not live long enough to develop Alzheimer's disease, but it and other age-related diseases are emerging as the major determinants of health costs as Australia moves towards the 21st century.
    Type of Medium: Online Resource
    ISSN: 0955-6036 , 1472-1473
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 1992
    detail.hit.zdb_id: 2022148-4
    detail.hit.zdb_id: 1008531-2
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  • 2
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 2020
    In:  BJPsych Bulletin Vol. 44, No. 2 ( 2020-04), p. 67-74
    In: BJPsych Bulletin, Royal College of Psychiatrists, Vol. 44, No. 2 ( 2020-04), p. 67-74
    Abstract: Early detection of Alzheimer's disease is vital for developing novel treatments. Attempts to identify the intermediate state between normal cognition and dementia have evolved over the past 50 years. Current taxonomies of mild cognitive impairment (MCI) may be criticised for their imprecise operationalisation. With the advent of biomarkers such as amyloid-beta positron emission tomography imaging in established Alzheimer's disease, much research has focused on establishing which factors predict progression from MCI to Alzheimer's disease dementia. In this review, we discuss the historical context of MCI before reviewing the literature of MCI subtypes and their risk of progression to Alzheimer's disease dementia. Finally, we summarise the literature and discuss limitations and weaknesses of how the construct is operationalised and implemented, before offering suggestions for development of the concept of MCI. We conclude that MCI must be empirically defined for the sake of its predictive validity to identify Alzheimer's disease before dementia develops.
    Type of Medium: Online Resource
    ISSN: 2056-4694 , 2056-4708
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2020
    detail.hit.zdb_id: 2816886-0
    detail.hit.zdb_id: 2813703-6
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  • 3
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 1984
    In:  British Journal of Psychiatry Vol. 145, No. 2 ( 1984-08), p. 193-194
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 145, No. 2 ( 1984-08), p. 193-194
    Abstract: Medical journals are enlivened by case reports of bizarre and unusual syndromes. Although somatic delusions are relatively common in schizophrenia, reports of hallucinations and delusions of bicephaly are rare. For a patient to attempt to remove a perceived second head by shooting and to survive the experience for more than two years may well be unique, and merits presentation.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 1984
    detail.hit.zdb_id: 218103-4
    detail.hit.zdb_id: 2021500-9
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  • 4
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 204, No. 5 ( 2014-05), p. 400-401
    Abstract: Although beta-amyloid, anxiety and depression have been linked cross-sectionally to reduced memory function in healthy older adults without dementia, prospective data evaluating these associations are lacking. Using data from an observational cohort study of 178 healthy older adults without dementia followed for 3 years, we found that anxiety symptoms significantly moderated the relationship between beta-amyloid level and decline in verbal (Cohen's d = 0.65) and episodic (Cohen's d = 0.38) memory. Anxiety symptoms were additionally linked to greater decline in executive function, irrespective of beta-amyloid and other risk factors. These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2014
    detail.hit.zdb_id: 218103-4
    detail.hit.zdb_id: 2021500-9
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  • 5
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 1990
    In:  British Journal of Psychiatry Vol. 156, No. 5 ( 1990-05), p. 667-675
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 156, No. 5 ( 1990-05), p. 667-675
    Abstract: Of 390 residents in 12 local-authority homes for the elderly, 93 had evidence of depression on screening and underwent standard clinical assessment. Half had an affective disorder, and a further third had depressive symptoms in the setting of an organic mental disorder. The 93 residents had a high rate of physical illness and disability, undertook little social activity, and were visited infrequently. A range of interventions for depressed residents, the majority social in type, mostly proved difficult to implement. There was no evidence of efficacy of psychiatric intervention at three months; at one-year follow-up a quarter of study participants had died, and 28% of those who were reassessed for depression showed evidence of recovery.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 1990
    detail.hit.zdb_id: 218103-4
    detail.hit.zdb_id: 2021500-9
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  • 6
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 1987
    In:  British Journal of Psychiatry Vol. 151, No. 6 ( 1987-12), p. 861-861
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 151, No. 6 ( 1987-12), p. 861-861
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 1987
    detail.hit.zdb_id: 218103-4
    detail.hit.zdb_id: 2021500-9
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  • 7
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 1996
    In:  British Journal of Psychiatry Vol. 168, No. 6 ( 1996-06), p. 679-687
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 168, No. 6 ( 1996-06), p. 679-687
    Abstract: An age-related dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis is well recognised in animals, but still remains controversial in humans. There is increasing interest that raised corticosteroid levels, due to activation of the HPA axis, may cause both depressive symptoms and cognitive impairments. Steroid effects on cognition may be via the hippocampus, a major site of corticosteroid action and an important structure involved in learning and memory. Method To investigate this further, we examined the relationship between the dexamethasone suppression test, cognitive function, depressive symptoms and hippocampal atrophy on magnetic resonance imaging (MRI) in 32 normal controls, 49 subjects with NINCDS/ADRDA Alzheimer's disease and 51 patients with DSM–III–R Major Depression. Results Controlling for differences in dexamethasone concentrations, post-dexamethasone cortisol levels were related to advancing age in controls and depressed subjects. However, among subjects with Alzheimer's disease, post-dexamethasone cortisol levels were independently associated with both minor depressive symptoms and hippocampal atrophy on MRI. Conclusion An association between advancing age and increased HPA axis dysregulation is supported for controls and depressed subjects. In Alzheimer's disease, HPA axis changes were associated with depressive symptoms and hippocampal atrophy. Longitudinal studies are now needed to determine the causal direction of these associations.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 1996
    detail.hit.zdb_id: 218103-4
    detail.hit.zdb_id: 2021500-9
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  • 8
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 1996
    In:  British Journal of Psychiatry Vol. 168, No. 4 ( 1996-04), p. 477-485
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 168, No. 4 ( 1996-04), p. 477-485
    Abstract: White matter changes, as revealed by magnetic resonance imaging (MRI), may occur in depression and Alzheimer's disease. Method T2-weighted MRI scans were performed in 39 control subjects, 61 subjects with NINCDS/ADRDA Alzheimer's disease and 60 subjects with DSM–III–R major depression. Deep white matter lesions (DWML) and periventricular lesions (PVL) were rated on a standard 0–3 scale by two radiologists blind to clinical diagnosis. Results After controlling for differences in vascular risk factors and current blood pressure, DWML were significantly more common in depressed subjects and PVL in Alzheimer's disease subjects compared to controls. DWML were most common in those presenting in late life with their first ever depression and 50% of such subjects had severe (grade 3) DWML. Conclusion An association between DWML and depression and PVL and Alzheimer's disease is supported. The increase with DWML that occurs with ageing may predispose some elderly subjects to depression.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 1996
    detail.hit.zdb_id: 218103-4
    detail.hit.zdb_id: 2021500-9
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  • 9
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 1997
    In:  British Journal of Psychiatry Vol. 171, No. 1 ( 1997-07), p. 99-100
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 171, No. 1 ( 1997-07), p. 99-100
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 1997
    detail.hit.zdb_id: 218103-4
    detail.hit.zdb_id: 2021500-9
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  • 10
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 1994
    In:  British Journal of Psychiatry Vol. 165, No. 5 ( 1994-11), p. 650-657
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 165, No. 5 ( 1994-11), p. 650-657
    Abstract: To investigate an association between HPA axis dysfunction, depression and cognitive impairment, we assessed subjects with mild Alzheimer's disease (AD). Method Sixteen non-depressed subjects with AD according to NINCDS/ADRDA criteria and 18 normal controls underwent the insulin hypoglycaemia (IH) test and the dexamethasone suppression test (DST). Results The AD subjects showed a blunted response of adrenocorticotrophic hormone (ACTH) to IH compared with controls ( P = 0.019). ACTH response (area under curve) correlated with a score for cognitive ability (CAMCOG) ( r = 0.64, P 〈 0.01). AD subjects had a shorter time to peak cortisol level than controls ( P = 0.004), although total cortisol response was normal. Conclusions The AD subjects show evidence of adrenal hyper-responsiveness and normal immediate (rate-sensitive) glucocorticoid feedback. An association between HPA axis dysfunction and organic brain pathology in AD subjects may be mediated by cell loss in the hippocampus.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 1994
    detail.hit.zdb_id: 218103-4
    detail.hit.zdb_id: 2021500-9
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