In:
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, Vol. 6, No. 1 ( 2017-01), p. 1-10
Abstract:
The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a mostly African‐American cohort. Methods We repeatedly measured 188 phospholipids/metabolites in plasma samples of 221 participants of the Atherosclerosis Risk in Communities study, 97% African American, who were followed between 2004–2006 and 2011–2013. Results After a mean follow‐up of 7.3 years, 77 were classified as having MCI and 18 as having dementia. Our study failed to replicate previous findings in this mostly African American cohort, in that the 10 phospholipids/metabolites only achieved a C statistic/AUC of 0.609 in predicting development of MCI or dementia (compared to 0.96) and 0.607 in distinguishing normal from MCI or dementia at the follow‐up visit. Conclusion A panel of 10 phospholipids/metabolites previously associated with incident dementia was not predictive of MCI or dementia in an independent cohort.
Type of Medium:
Online Resource
ISSN:
2352-8729
,
2352-8729
DOI:
10.1016/j.dadm.2016.09.003
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2832898-X
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