In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 10 ( 2022-10-4), p. e0274050-
Abstract:
Since the initial reported discovery of SARS-CoV-2 in late 2019, genomic surveillance has been an important tool to understand its transmission and evolution. Here, we sought to describe the underlying regional phylodynamics before and during a rapid spreading event that was documented by surveillance protocols of the United States Air Force Academy (USAFA) in late October-November of 2020. We used replicate long-read sequencing on Colorado SARS-CoV-2 genomes collected July through November 2020 at the University of Colorado Anschutz Medical campus in Aurora and the United States Air Force Academy in Colorado Springs. Replicate sequencing allowed rigorous validation of variation and placement in a phylogenetic relatedness network. We focus on describing the phylodynamics of a lineage that likely originated in the local Colorado Springs community and expanded rapidly over the course of two months in an outbreak within the well-controlled environment of the United States Air Force Academy. Divergence estimates from sampling dates indicate that the SARS-CoV-2 lineage associated with this rapid expansion event originated in late October 2020. These results are in agreement with transmission pathways inferred by the United States Air Force Academy, and provide a window into the evolutionary process and transmission dynamics of a potentially dangerous but ultimately contained variant.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0274050
DOI:
10.1371/journal.pone.0274050.g001
DOI:
10.1371/journal.pone.0274050.g002
DOI:
10.1371/journal.pone.0274050.g003
DOI:
10.1371/journal.pone.0274050.g004
DOI:
10.1371/journal.pone.0274050.g005
DOI:
10.1371/journal.pone.0274050.t001
DOI:
10.1371/journal.pone.0274050.t002
DOI:
10.1371/journal.pone.0274050.s001
DOI:
10.1371/journal.pone.0274050.s002
DOI:
10.1371/journal.pone.0274050.s003
DOI:
10.1371/journal.pone.0274050.s004
DOI:
10.1371/journal.pone.0274050.s005
DOI:
10.1371/journal.pone.0274050.s006
DOI:
10.1371/journal.pone.0274050.s007
DOI:
10.1371/journal.pone.0274050.s008
DOI:
10.1371/journal.pone.0274050.s009
DOI:
10.1371/journal.pone.0274050.s010
DOI:
10.1371/journal.pone.0274050.s011
DOI:
10.1371/journal.pone.0274050.s012
DOI:
10.1371/journal.pone.0274050.s013
DOI:
10.1371/journal.pone.0274050.s014
DOI:
10.1371/journal.pone.0274050.s015
DOI:
10.1371/journal.pone.0274050.s016
DOI:
10.1371/journal.pone.0274050.s017
DOI:
10.1371/journal.pone.0274050.r001
DOI:
10.1371/journal.pone.0274050.r002
DOI:
10.1371/journal.pone.0274050.r003
DOI:
10.1371/journal.pone.0274050.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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