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  • SAGE Publications  (2)
  • Ali-Hassan-Sayegh, Sadegh  (2)
  • 1
    In: Asian Cardiovascular and Thoracic Annals, SAGE Publications, Vol. 23, No. 3 ( 2015-03), p. 363-374
    Abstract: This systematic review with meta-analysis sought to determine the efficacy and safety of intramyocardial transplantation of bone marrow stem cells during coronary artery bypass graft surgery on postoperative cardiac functional parameters such as left ventricular ejection fraction and left ventricular end-diastolic volume. Methods Medline/PubMed, Embase, Elsevier, Sciences online database, and Google Scholar literature search were searched. The effect sizes measured were risk ratio for categorical variables and weighted mean difference with 95% confidence interval for calculating differences between mean values of baseline and follow-up cardiac functional parameters. A value of p  〈  0.1 for Q test, or I 2  〉  50%, indicated significant heterogeneity among studies. The literature search retrieved 2900 studies from screened databases, of which 2866 (98.6%) were excluded and 34 (619 patients) were included for scoping review. The final analysis included 9 studies (335 patients). Results Pooled effects estimates of left ventricular ejection fraction and left ventricular end-diastolic volume showed that bone marrow stem cell transplantation had a weighted mean difference of 4.06 (95% confidence interval: 0.41–7.72; p = 0.02) and 7.06 (95% confidence interval: −8.58–22.7; p = 0.3), respectively. Conclusions Intramyocardial transplantation of bone marrow stem cells improves cardiac functional parameters, significantly increasing left ventricular ejection fraction with a nonsignificant reduction in left ventricular end-diastolic volume. Also, this therapeutic method has no life-threatening complications and was therefore found to be an effective and safe method.
    Type of Medium: Online Resource
    ISSN: 0218-4923 , 1816-5370
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2044527-1
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  • 2
    In: Asian Cardiovascular and Thoracic Annals, SAGE Publications, Vol. 23, No. 3 ( 2015-03), p. 354-362
    Abstract: This systematic review with meta-analysis sought to determine the impact of posterior pericardiotomy on incidences of atrial fibrillation and supraventricular arrhythmias, pericardial effusion, pleural effusion, tamponade, and the length of hospital stay after cardiac surgery. We searched for randomized controlled trials, using Medline, Embase, Elsevier and Sciences online databases as well as Google Scholar literature. The effect sizes measured were odds ratio for categorical variables and standard mean difference with 95% confidence interval for calculating differences between mean values of hospital stay in intervention and control groups. A value of p  〈  0.1 for Q test or I 2  〉  50% indicated significant heterogeneity between the studies. The literature search of all major databases retrieved 20 studies. After screening, 12 suitable trials were identified, which reported outcomes of 2052 patients undergoing cardiac surgery. Posterior pericardiotomy had an odds ratio of 0.33 [95% confidence interval: 0.18–0.61] p  〈  0.001 for atrial fibrillation; odds ratio 0.32 [0.15–0.67] p = 0.003 for supraventricular arrhythmias; odds ratio 0.09 [0.04–0.19] p = 0.000 for early pericardial effusion and odds ratio 0.04 [0.02–0.08] p  〈  0.001 for late pericardial effusion; odds ratio 1.64 [1.23–2.20] p = 0.001 for pleural effusion, odds ratio 0.07 [0.02–0.27] p  〈  0.001 for tamponade, and standard mean difference = 0.01 [−0.12 to 0.14] p = 0.8 for hospital stay. Posterior pericardiotomy is a simple intraoperative technique that can improve postoperative clinical outcomes. However, the incidence of pleural effusion associated with posterior pericardiotomy might be higher.
    Type of Medium: Online Resource
    ISSN: 0218-4923 , 1816-5370
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2044527-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
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