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  • 1
    Online Resource
    Online Resource
    Lanthanum Doped Zinc Molybdate: Antibacterial and Photo-Catalysis Properties
    American Scientific Publishers ; 2022
    In:  Science of Advanced Materials Vol. 14, No. 8 ( 2022-08-01), p. 1320-1330
    Details
    In: Science of Advanced Materials, American Scientific Publishers, Vol. 14, No. 8 ( 2022-08-01), p. 1320-1330
    Abstract: This study investigates unique and specific properties of the lanthanum based zinc molybdate nanocomposite material. The lanthanum zinc molybdate nanocomposite material was synthesized using a simple and low cost “co-precipitation” method. The synthesized nano materials had structural, vibrational and morphological properties, determined by X-ray diffraction, fourier-transform infrared spectroscopy and field emission scanning electron microscopy. The synthesized nanomaterial was characterised using a range of techniques. X-ray diffraction was used to determine a particle size of 65.7 nm of the disc shaped hexagonal particle. Further characterisation was done using UV-visible spectroscopy and band gap energy analysis. The band gap value was found to be 3.58 eV. The nanocomposite also exhibited antibacterial activity against bacterial strains of Escherichia coli and Staphylococcus aureus . In the presence of light and air, nanoparticles of lanthanum zinc molybdate nanocomposite were found to inhibit the growth of Escherichia coli due to generation of singlet oxygen and hydrogen oxide radical. However, the same was not observed for S. aureus . Photocatalytic property of lanthanum zinc molybdate nanocomposite was determined using an aqueous solution of methylene blue dye. lanthanum zinc molybdate nanocomposite showed photo-degradation due to the formation of singlet oxygen and hydrogen oxide radical. Complete decolourization of blue colour of the of methylene blue solution at 6 pH was attained, using 40.0 mg lanthanum zinc molybdate nanocomposite, with a constant time interval. With time, the activity of lanthanum zinc molybdate nanocomposite was also found to decrease due to the formation of a hydrogen oxide layer on the surface of the nano material. This could be washed off with ethanol and distilled water. After drying, the catalytic nano particle could be reused for another reaction.
    Type of Medium: Online Resource
    ISSN: 1947-2935
    URL: Article
    DOI: 10.1166/sam.2022.4327
    Language: English
    Publisher: American Scientific Publishers
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Eco-Synthesis of Gold Nanoparticles Using Vigna unguiculata Seed Extract: A Leap in the Direction of Antiglycation Remedies
    American Scientific Publishers ; 2024
    In:  Science of Advanced Materials Vol. 16, No. 5 ( 2024-05-01), p. 614-623
    Details
    In: Science of Advanced Materials, American Scientific Publishers, Vol. 16, No. 5 ( 2024-05-01), p. 614-623
    Abstract: Nanotechnology, an interdisciplinary field that merges physics, chemistry, and biology, has emerged as a catalyst for innovation, offering far-reaching implications across various scientific disciplines. Gold nanoparticles (GNPs), with their unique physicochemical properties and biocompatibility, have become a focal point in this technological revolution. This research delves into the eco-friendly synthesis of gold nanoparticles using Vigna unguiculata seed extract, a botanical resource known for its rich phytochemical composition. The study investigates the antiglycation activities of these nanoparticles, drawing insights from existing literature. The synthesis process involves the reduction of gold ions by the bioactive compounds present in the Vigna unguiculata seed extract (VuS), leading to the formation of Vigna unguiculata derived GNPs (V-GNPs). Comprehensive characterization techniques, including UV-Vis spectroscopy and transmission electron microscopy, were employed to confirm the stability, size, and shape of the synthesized nanoparticles. The research aligns with recent studies suggesting the potential of gold nanoparticles in mitigating glycation-related disorders. Glycation is a biochemical process implicated in various health complications, particularly diabetes. The antiglycation properties of V-GNPs, as revealed in this study, present an intriguing avenue for managing diabetes and associated complications. The unique composition of V-GNPs, coupled with their promising antiglycation properties, underscores their potential as effective therapeutic agents in the fight against diabetes and other glycation-related disorders. This research not only contributes to the existing body of knowledge but also opens up new possibilities for the application of V-GNPs in the realm of nanomedicine.
    Type of Medium: Online Resource
    ISSN: 1947-2935
    URL: Article
    DOI: 10.1166/sam.2024.4671
    Language: English
    Publisher: American Scientific Publishers
    Publication Date: 2024
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  • 3
    Online Resource
    Online Resource
    Bioremediation potential of Pseudomonas fluorescens strain isolated from the Ha段l region of Saudi Arabia
    Biomedical Informatics ; 2023
    In:  Bioinformation Vol. 19, No. 9 ( 2023-9-30), p. 901-907
    Details
    In: Bioinformation, Biomedical Informatics, Vol. 19, No. 9 ( 2023-9-30), p. 901-907
    Abstract: Increased amounts of toxicants may cause sever health issues in humans as well as in aquatic life. Scientists are developing new technologies to combat these problems. Biological methods of detoxification are always beneficial for the environment. Pseudomonas fluorescens is known for its detoxification capacity. In this study Pseudomonas fluorescens stains were isolated from different locations of the Ha段l region, Saudia Arabia. The microbial strain AM-1 displayed resistance to heavy metals (Cr6+, Ni2+, Cd2+, Pb2+) and pesticides (BHC, 2,4-D, Mancozeb) at pollutant levels typical of highly contaminated areas. Additionally, AM-1 exhibited substantial detoxification potential, reducing toxicity by 40.67% for heavy metals and 47.4% for pesticides at 3x concentrations. These findings suggest that the AM-1 strain supports environmental remediation and pollution mitigation. Atomic absorption spectrometry (AAS) results exhibited bioremediation efficiency for metals Cr6+, Ni2+, and Pb2+ using immobilized cells of P. fluorescens AM-1 isolate, estimated to be 60.57%, 68.4%, and 53.93% respectively. These findings show that AM-1 strain has a potential role in bioremediation of water pollutants and may have future implications in wastewater treatment.
    Type of Medium: Online Resource
    ISSN: 0973-8894 , 0973-2063
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.6026/019-09
    DOI: 10.6026/bioinformation
    DOI: 10.6026/97320630019901
    Language: Unknown
    Publisher: Biomedical Informatics
    Publication Date: 2023
    detail.hit.zdb_id: 2203786-X
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  • 4
    Online Resource
    Online Resource
    Optimization of Pseudomonas aeruginosa isolated for bioremediation from Ha’il region of Saudi Arabia
    Biomedical Informatics ; 2023
    In:  Bioinformation Vol. 19, No. 9 ( 2023-9-30), p. 893-900
    Details
    In: Bioinformation, Biomedical Informatics, Vol. 19, No. 9 ( 2023-9-30), p. 893-900
    Abstract: Majority of dyes are toxic to all the living organisms and inherently resistant to microbial degradation. Hence, decolorization and degradation of textile dye methyl red were evaluated using isolated bacterial strain Pseudomonas aeruginosa (P. aeruginosa). Methyl red dye decolourization by P. aeruginosa with respect to various parameters was optimized. Data shows that maximum possible decolorization was seen at 50 ppm dye concentration, 1400 mg/l glucose concentration, 700 mg/l sodium chloride (NaCl) concentration, pH 9, temperature 38 °C, 1000 mg/l urea concentration P. aeruginosa AM-1 strain. The highest percent (91.1%) of bioremediation was achieved at 40 ppm dye concentration in Allium cepa test. These findings suggest P. aeruginosa strain (AM-1) has the potential to be used in the biological treatment of highly toxic dye which is main constituent of dyeing mill effluents due to its high decolorization activity with simple conditions. Strain AW-1 strain also has potential to bioremediate other wastewater containing methyl red dye.
    Type of Medium: Online Resource
    ISSN: 0973-8894 , 0973-2063
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.6026/019-09
    DOI: 10.6026/bioinformation
    DOI: 10.6026/97320630019893
    Language: Unknown
    Publisher: Biomedical Informatics
    Publication Date: 2023
    detail.hit.zdb_id: 2203786-X
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  • 5
    Online Resource
    Online Resource
    Glycation end-products specific auto-antibodies in Systemic Lupus Erythematosus
    Biomedical Informatics ; 2022
    In:  Bioinformation Vol. 18, No. 3 ( 2022-3-31), p. 127-133
    Details
    In: Bioinformation, Biomedical Informatics, Vol. 18, No. 3 ( 2022-3-31), p. 127-133
    Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease, which is highly inflammatory. Compared to a healthy control group, SLE patients exhibit a higher concentration of advanced glycation end products (AGEs) and a lower concentration of receptors for AGEs (RAGE) in serum, however, the exact aetiology is still unclear. In the present study, non-enzymatic glycation induced modification of human serum albumin (HSA) has been studied by biophysical techniques. Glycated HSA (G-HSA) was used as an antigen, and serum autoantibody levels were estimated in SLE and normal humans (NH) against it, using direct binding ELISA and competitive inhibition ELISA. Compared to N-HSA, remarkable structural modifications were observed in G-HSA. Modified HSA also showed increased pentosidine fluorescence (213.7 ± 13.4 AU). Glycation of HSA induced a conversion of α-helix and random coil to β-sheet and β-turns. Serum immuno assays results exhibited significantly (p 〈 0.001) higher binding of G-HSA with serum autoantibodies from SLE patients when compared with native HSA (N-HSA). Furthermore, competitive ELISA results showed significantly (p 〈 0.001) high percent inhibition of serum IgG from SLE patients with modified antigen. Chronic inflammation with excessive oxidative stress in SLE patients could be a possible reason for structural alterations in blood proteins, generating highly immunogenic unique new-epitopes. These in turn induce the generation of specific autoantibodies against G-HSA that may serve as a potential biomarker for SLE pathogenesis.
    Type of Medium: Online Resource
    ISSN: 0973-8894 , 0973-2063
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.6026/018-03
    DOI: 10.6026/bioinformation
    DOI: 10.6026/97320630018127
    Language: Unknown
    Publisher: Biomedical Informatics
    Publication Date: 2022
    detail.hit.zdb_id: 2203786-X
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  • 6
    Online Resource
    Online Resource
    Optimization of methods for peripheral blood mononuclear cells isolation and expansion of human gamma delta T cells
    Biomedical Informatics ; 2021
    In:  Bioinformation Vol. 17, No. 3 ( 2021-3-31), p. 460-470
    Details
    In: Bioinformation, Biomedical Informatics, Vol. 17, No. 3 ( 2021-3-31), p. 460-470
    Abstract: Human Vγ9/Vδ2 T cells (γδ T cells) are immune surveillance cells both in innate and adaptive immunity and are a possible target for anticancer therapies, which can induce immune responses in a variety of cancers. Small non-peptide antigens such as zoledronate can do activation and expansion of T cells in vitro. It is evident that for adoptive cancer therapies, large numbers of functional cells are needed into cancer patients. Hence, optimization of methods needs to be carried out for the efficient expansion of these T cells. Standardization of peripheral blood mononuclear cells (PBMCs) isolation was devised. Cytokines (interleukin 2 (IL-2) and interleukin 15 (IL-15)) and zoledronate were also standardized for different concentrations. It was found that an increased number of PBMCs were recovered when washing was done at 1100 revolution per minute (rpm). Significantly high expansion fold was (2524 ± 787 expansion fold) achieved when stimulation of PBMCs was done with 1 μM of zoledronate and both cytokines IL-2 and IL-15 supported the expansion and survival of cells ISSN 0973-2063 (online) 0973-8894 (print) Bioinformation 17(3): 460-469 (2021) ©Biomedical Informatics (2021) 461 at the concentrations of 100 IU/ml and 10 ng/ml respectively. 14-day cultures showed highly pure (91.6 ± 5.1%) and live (96.5 ± 2.5%) expanded γδ T cells. This study aimed to standardize an easy to manipulate technique for the expansion of γδ T cells, giving a higher yield.
    Type of Medium: Online Resource
    ISSN: 0973-8894 , 0973-2063
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.6026/17.3
    DOI: 10.6026/bioinformation
    DOI: 10.6026/97320630017460
    Language: Unknown
    Publisher: Biomedical Informatics
    Publication Date: 2021
    detail.hit.zdb_id: 2203786-X
    Location Call Number Limitation Availability
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    Online Resource
  • 7
    Online Resource
    Online Resource
    Optimization of methods for peripheral blood mononuclear cells isolation and expansion of human gamma delta T cells
    Biomedical Informatics ; 2021
    In:  Bioinformation Vol. 17, No. 3 ( 2021-3-31), p. 460-470
    Details
    In: Bioinformation, Biomedical Informatics, Vol. 17, No. 3 ( 2021-3-31), p. 460-470
    Abstract: Human Vγ9/Vδ2 T cells (γδ T cells) are immune surveillance cells both in innate and adaptive immunity and are a possible target for anticancer therapies, which can induce immune responses in a variety of cancers. Small non-peptide antigens such as zoledronate can do activation and expansion of T cells in vitro. It is evident that for adoptive cancer therapies, large numbers of functional cells are needed into cancer patients. Hence, optimization of methods needs to be carried out for the efficient expansion of these T cells. Standardization of peripheral blood mononuclear cells (PBMCs) isolation was devised. Cytokines (interleukin 2 (IL-2) and interleukin 15 (IL-15)) and zoledronate were also standardized for different concentrations. It was found that an increased number of PBMCs were recovered when washing was done at 1100 revolution per minute (rpm). Significantly high expansion fold was (2524 ± 787 expansion fold) achieved when stimulation of PBMCs was done with 1 μM of zoledronate and both cytokines IL-2 and IL-15 supported the expansion and survival of cells ISSN 0973-2063 (online) 0973-8894 (print) Bioinformation 17(3): 460-469 (2021) ©Biomedical Informatics (2021) 461 at the concentrations of 100 IU/ml and 10 ng/ml respectively. 14-day cultures showed highly pure (91.6 ± 5.1%) and live (96.5 ± 2.5%) expanded γδ T cells. This study aimed to standardize an easy to manipulate technique for the expansion of γδ T cells, giving a higher yield.
    Type of Medium: Online Resource
    ISSN: 0973-8894 , 0973-2063
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.6026/17.3
    DOI: 10.6026/bioinformation
    DOI: 10.6026//97320630017460
    Language: Unknown
    Publisher: Biomedical Informatics
    Publication Date: 2021
    detail.hit.zdb_id: 2203786-X
    Location Call Number Limitation Availability
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    Online Resource
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