In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
Kurzfassung:
Introduction: The long-term effects of severe obesity [body mass index (BMI) ≥50 kg/m 2 ) on the outcomes of Transcatheter Aortic Valve implantation (TAVI) remains unknown. Methods: The National Readmission Database (NRD) was used from 2015-2019 to identify all patients undergoing TAVI. Patients with severe obesity were compared with those having BMI 〈 50 kg/m 2 . The adjusted odds ratios (aOR) and 95% confidence interval (CI) were calculated using a propensity-score matched analysis (PSM).(Fig 1) Results: A total of 184,199 patients were included in the crude analysis. A selected sample of 4669 [2369 (50.7%) severely obese, and non-obese 2300 (49.3%)] were included in PSM analysis. At index admission, the adjusted odds of net adverse clinical events (NACE) (aOR 1.57, 95% CI 1.12 -2.20, p=0.01), all-cause in-hospital mortality (aOR 8.08, 95% CI 3.19-20.48, p= 〈 0.0001), and acute kidney injury were (aOR 1.48, 95% CI 1.25-1.74, p= 〈 0.0001) were significantly higher in severely obese patients compared with those having with BMI 〈 50 kg/m 2 . There was no difference in stroke (aOR 0.60, 95% CI 0.32-1.11, p=0.14), or major bleeding (aOR 1.63, 1.01-2.64, p=0.06) between the two groups. At 30- and 180-day, there was no significant difference in the incidence of stroke, or major bleeding between the two groups.(Fig 2) There was a steep increase in the utilization of TAVI in severely obese patients from 17.6% to 31.8% per total procedures during 2016 to 2019. Conclusions: Severely obese (BMI ≥50 kg/m 2) recipients of TAVI have a higher risk of NACE and mortality, however, there appearsto be no significant difference in the long-term risk of complications between severely obese and non-obese patients.
Materialart:
Online-Ressource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.146.suppl_1.14184
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2022
ZDB Id:
1466401-X
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