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  • Ovid Technologies (Wolters Kluwer Health)  (4)
  • Alberti, K G  (4)
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  • Ovid Technologies (Wolters Kluwer Health)  (4)
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  • 1
    Online Resource
    Online Resource
    Lipoprotein compositional abnormalities and insulin resistance in type II diabetic patients with mild hyperlipidemia.
    Ovid Technologies (Wolters Kluwer Health) ; 1993
    In:  Arteriosclerosis and Thrombosis: A Journal of Vascular Biology Vol. 13, No. 7 ( 1993-07), p. 1046-1052
    Details
    In: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 13, No. 7 ( 1993-07), p. 1046-1052
    Abstract: Lipoprotein composition was determined using ultracentrifugation in 20 non-insulin-dependent (NIDDM) diabetic patients on diet only (D), 20 NIDDM patients on diet and sulfonylurea therapy (T), and 20 nondiabetic control subjects (C), all of whom had total plasma cholesterol concentrations 〈 6.5 mmol/L and total plasma triglyceride concentrations 〈 3.0 mmol/L. Although the groups were well matched for age, body mass index, total triglyceride levels, and total cholesterol concentrations, there were significant compositional abnormalities in the low-density lipoprotein (LDL) fractions of diabetic subjects. The LDL total lipid to apolipoprotein B weight ratio (representing the density distributions of LDL particles) was reduced in both diabetic groups: 3.75 +/- 0.3, 3.50 +/- 0.28, and 3.54 +/- 0.22 in C, D, and T groups, respectively (mean +/- SD; P 〈 .05). This was associated with a significant shift in the hydrated density distributions of LDL in the diabetic groups, with the average peak densities being 1.0320 g/mL (in C), 1.0365 g/mL (in D), and 1.0380 g/mL (in T) (P 〈 .05). The LDL particles were also smaller in the NIDDM patients: 21.1 +/- 0.7, 20.4 +/- 0.5, and 20.6 +/- 0.5 nm in C, D, and T groups, respectively (P 〈 .05). When the NIDDM groups were analyzed together, the LDL peak density was found to correlate with both insulin resistance (measured by a modified Harano technique; r = 0.37, P 〈 .015) and total triglyceride concentrations (r = 0.40, P 〈 .01). The results show that diabetic patients have small, dense LDL particles, which may be related to insulin resistance, and that these occur with minimal elevations of total triglyceride concentrations. These potentially atherogenic changes may contribute to the increased coronary heart disease in diabetic patients with mild hyperlipidemia.
    Type of Medium: Online Resource
    ISSN: 1049-8834
    URL: Article
    DOI: 10.1161/01.ATV.13.7.1046
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1993
    detail.hit.zdb_id: 1494427-3
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  • 2
    Online Resource
    Online Resource
    High insulin-like growth factor binding protein 1 levels in cirrhosis: Link with insulin resistance
    Ovid Technologies (Wolters Kluwer Health) ; 1996
    In:  Hepatology Vol. 24, No. 1 ( 1996-07), p. 127-133
    Details
    In: Hepatology, Ovid Technologies (Wolters Kluwer Health), Vol. 24, No. 1 ( 1996-07), p. 127-133
    Type of Medium: Online Resource
    ISSN: 0270-9139 , 1527-3350
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/hep.v24:1
    DOI: 10.1002/(ISSN)1527-3350
    DOI: 10.1002/hep.510240122
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1996
    detail.hit.zdb_id: 1472120-X
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  • 3
    Online Resource
    Online Resource
    Relation between insulinemia, body mass index, and lipoprotein composition in healthy, nondiabetic men and women.
    Ovid Technologies (Wolters Kluwer Health) ; 1992
    In:  Arteriosclerosis and Thrombosis: A Journal of Vascular Biology Vol. 12, No. 3 ( 1992-03), p. 393-402
    Details
    In: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 12, No. 3 ( 1992-03), p. 393-402
    Abstract: Altered lipoprotein composition may be a better predictor of cardiovascular disease than modestly increased serum lipid concentrations, although possible interactions between lipoprotein composition, obesity, and insulinemia have not been fully elucidated. Therefore, we investigated the association between different measures of insulinemia and lipoproteins in 297 healthy Caucasian men (body mass index [BMI] less than 27 in 233, greater than 27 [obese] in 64) and 295 healthy Caucasian women (BMI less than 25 in 198, greater than 25 [obese] in 97). Associations observed in both obese and nonobese men and women were between increasing tertiles of most insulin measures and serum triglyceride concentrations (p = 0.079-0.004) and the ratio of low density lipoprotein to high density lipoprotein cholesterol (p = 0.094-0.008). Graded reductions in the high density lipoprotein cholesterol to apolipoprotein A-I ratio were also recorded in obese women, with increasing tertiles of fasting (p = 0.014-0.007) and po stglucose load (p = 0.001) serum insulin levels, after correcting for BMI and triglyceride concentrations. Less marked graded increases in the triglyceride to apolipoprotein B ratios were recorded in obese women with increasing tertiles of fasting (p = 0.001-0.006) and postglucose challenge (p = 0.081) insulinemic measures. In men with normal or slightly elevated cholesterol levels (fasting serum cholesterol less than 6.5 mmol/l), hyperapobetalipoproteinemia was recorded with increasing tertiles of insulinemia (p = 0.006, correcting for BMI and triglyceride concentrations), as well as in subjects with hypertriglyceridemia (fasting serum triglycerides greater than 1.70 mmol/l) (p = 0.004, correcting for BMI and age). Hyperinsulinemia and insulin resistance are associated with altered lipoprotein composition in obese women, presumably reflecting a complex interplay between sex hormones, body mass, and insulin action. Insulin resistance appears to be more associated with apolipoprotein B concentrations in men. The hyperinsulinemic nondiabetic subject may be at increased risk of cardiovascular disease because of altered concentrations of apolipoprotein concentrations and lipoprotein composition.
    Type of Medium: Online Resource
    ISSN: 1049-8834
    URL: Article
    DOI: 10.1161/01.ATV.12.3.393
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1992
    detail.hit.zdb_id: 1494427-3
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  • 4
    Online Resource
    Online Resource
    Coronary artery disease is associated with increased lipoprotein(a) concentrations independent of the size of circulating apolipoprotein(a) isoforms.
    Ovid Technologies (Wolters Kluwer Health) ; 1994
    In:  Arteriosclerosis and Thrombosis: A Journal of Vascular Biology Vol. 14, No. 8 ( 1994-08), p. 1272-1283
    Details
    In: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 14, No. 8 ( 1994-08), p. 1272-1283
    Abstract: Lipoprotein(a) [Lp(a)] concentration and apolipoprotein(a) [apo(a)] isoforms (identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis [SDS-PAGE] and Western blotting) were determined in a group of 508 asymptomatic Caucasian members of the community and in 318 Caucasian patients with angiographically defined coronary artery disease (CAD). Conventional risk factors for CAD were also measured. Lp(a) concentration was almost twice as high in subjects with CAD (geometric mean, 152 mg/L [geometric SD, 10 to 1398 mg/L] ) as in asymptomatic control subjects (geometric mean, 84 mg/L [geometric SD, 21 to 334 mg/L]). Asymptomatic women had higher concentrations of Lp(a) than asymptomatic men. Patients with CAD were older and were more likely to have smoked and to have a first-degree relative with premature CAD ( 〈 55 years of age), and a higher proportion were male. Patients with CAD had higher concentrations of Lp(a) independently of the number of isoform bands expressed. When apo(a) isoforms were allocated to 1 of 10 classes on the basis of their molecular size (Rf versus apoB in SDS-PAGE), patients with CAD did not express an excess of low-molecular-mass (higher concentration) isoforms but did express a higher proportion of double-band phenotypes with fewer "null" phenotypes. The relationship between the two isoform bands in a double-band phenotype was the same in both populations. Isoform mobility was defined as a continuous variable equal to the mobility of a single isoform band (single-band phenotypes) or the mean of the two isoforms in a double-band phenotype. Two variables, isoform mobility and the number of isoform bands expressed, were used to summarize the large range of isoform patterns (at least 45) that could be identified. Isoform mobility, the number of isoform bands expressed, and the presence of CAD were the three most important independent predictors of Lp(a) concentration (descending order). Only sex and LDL cholesterol were additional independent predictors of Lp(a) concentration in step-wise regression models including a wide range of demographic factors and lipid and glycemic risk factors. We conclude that Lp(a) concentration is associated with CAD independently of the isoform pattern expressed. The apo(a) gene locus exerts a strong control over circulating Lp(a) concentration, and a better understanding of the control of expression of the apo(a) gene will be essential to understand the relationship between Lp(a) and CAD.
    Type of Medium: Online Resource
    ISSN: 1049-8834
    URL: Article
    DOI: 10.1161/01.ATV.14.8.1272
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1994
    detail.hit.zdb_id: 1494427-3
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