In:
ECS Meeting Abstracts, The Electrochemical Society, Vol. MA2014-02, No. 51 ( 2014-08-05), p. 2306-2306
Abstract:
The aim of this work is to create a biocompatible superparamagnetic nanocomposite applicable as vehicle for magnetically guided drug delivery. Therefore Fe 3 O 4 -nanoparticles have been infiltrated or chemically grown within nanostructured silicon. Both materials, the nanostructured silicon as well as the iron oxide nanoparticles, offer low toxicity and investigations concerning the cell-viability have been carried out. The magnetic properties of the system have been optimized concerning the blocking temperature T B and the magnetic moment M which means that T B has to be far below room temperature and M should be as high as possible, whereas these both properties are counteracting. T B indicates the transition between superparamagnetic behavior and blocked state of the composite. Due to the fact that T B is not only dependent on the particle size (diameters between 4 and 10 nm have been investigated) but also on the magnetic interactions between the particles there are two main routes to fabricate such a composite with desired T B - first a modification of the pore-loading with a concomitant variation of the distance between the particles within one pore and second a variation of the porous silicon morphology influencing the distance between particles within adjacent pores. To ensure that there is no remanence after the external field has been switched off, magnetic coupling between the particles has to be kept sufficiently low. A particle-size/distance and template dependent assessment of the magnetic properties and the cytotoxicity of the nanocomposite will be presented. Furthermore the differences between infiltrated Fe 3 O 4 -nanoparticles and chemically grown particles inside the pores will be figured out.
Type of Medium:
Online Resource
ISSN:
2151-2043
DOI:
10.1149/MA2014-02/51/2306
Language:
Unknown
Publisher:
The Electrochemical Society
Publication Date:
2014
detail.hit.zdb_id:
2438749-6
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