In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 139, No. 1 ( 2006), p. 25-30
Abstract:
〈 i 〉 Background: 〈 /i 〉 Interleukin (IL)-13 has come to be appreciated as a molecule critically involved in allergic inflammatory responses. Recent studies revealed that a common variant in the coding region of the 〈 i 〉 IL13 〈 /i 〉 gene, Arg110Gln, has been implicated in the development of asthma and atopy. 〈 i 〉 Methods: 〈 /i 〉 To assess whether the 〈 i 〉 IL13 〈 /i 〉 variant Arg110Gln is associated with cedar pollinosis, one of the most common atopic diseases in the Japanese population, we examined the Arg110Gln variant using PCR-RFLP to compare the genotype and allele frequencies between 95 patients with cedar pollinosis and 95 healthy control subjects. Relationships between the Arg110Gln variant and the pollinosis-related traits, e.g. rhinitis severity, eosinophil counts in nasal secretion and serum total and allergen-specific IgE levels, were also investigated. 〈 i 〉 Results: 〈 /i 〉 The frequencies of the minor allele Gln110 were 25.8% in patients with cedar pollinosis and 30.9% in healthy control subjects (p 〉 0.05). There was also no significant difference in the genotype frequencies between cases and controls (p 〉 0.05). In addition, we found no significant association of the Arg110Gln variant with any of the pollinosis-related phenotypes (p 〉 0.05). 〈 i 〉 Conclusions: 〈 /i 〉 Our data suggest lack of evidence for identifying the variant Arg110Glnat the 〈 i 〉 IL13 〈 /i 〉 locus as a genetic risk factor involved in the development of Japanese cedar pollinosis.
Type of Medium:
Online Resource
ISSN:
1018-2438
,
1423-0097
Language:
English
Publisher:
S. Karger AG
Publication Date:
2006
detail.hit.zdb_id:
1482722-0
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