In:
Journal of Applied Toxicology, Wiley, Vol. 40, No. 11 ( 2020-11), p. 1467-1479
Abstract:
The present study investigated the relationship between LDLRAD4 downregulation and TGFβ signaling during nongenotoxic hepatocarcinogenesis in rats. Immunohistochemically, LDLRAD4‐downregulated GST‐P + foci revealed a phenotype suggestive of disruptive activation of TGFβ signaling to enhance EGFR and PTEN/AKT‐dependent pathways via caveolin‐1‐dependent activation of TACE/ADAM17. The LDLRAD4‐downregulated foci also facilitated proliferation and attenuated apoptosis. Increased incidence of LDLRAD4 downregulation in neoplastic lesions suggested a role in tumor development. Thus, nongenotoxic hepatocarcinogens may cause disruptive activation of TGFβ signaling through downregulating LDLRAD4 toward hepatocarcinogenesis.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1475015-6
Permalink