In:
Journal of Medical Virology, Wiley, Vol. 45, No. 4 ( 1995-04), p. 373-380
Kurzfassung:
To elucidate the relationship between the clinical severity of chronic liver disease and the precore mutations in hepatitis B e antigen (HBeAg)‐nega‐tive hepatitis B virus (HBV) carriers, mutations were investigated in the precore region of HBV DNA in 20 chronic hepatitis B patients who sero‐converted either spontaneously or after the administration of α‐interferon (IFN), and 5 asymptomatic carriers. The precore mutation with a stop codon at nucleotide 1896 was found in all patients, irrespective of the histology and in all asymptomatic carriers. The second mutation at nucleotide 1899 was found in 40% of cases studied but always followed by the first mutation at nucleotide 1896. The mixed viral infection of precore mutant and wild‐type HBV virus was found in 40% of seroconverted cases after IFN treatment and in sera of HBV carriers obtained within a year after the spontaneous Seroconversion. These data suggest that the precore mutants prevail over wild‐type HBV in all HBeAg‐negative HBV carriers within several years after the sero‐conversion, but their prevalence could not confine the clinical severity of chronic liver disease. © 1995 Wiley‐Liss, Inc.
Materialart:
Online-Ressource
ISSN:
0146-6615
,
1096-9071
DOI:
10.1002/jmv.1890450404
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1995
ZDB Id:
752392-0
ZDB Id:
1475090-9
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