In:
The Journal of Dermatology, Wiley, Vol. 48, No. 9 ( 2021-09), p. 1423-1427
Abstract:
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse skin reactions characterized by high fever, epidermal detachment, and mucositis. It is well known that SJS/TEN occasionally affects various organs, leading to permanent damage and death in some patients. Although acute liver dysfunction is a relatively common complication of SJS/TEN, severe acute liver dysfunction requiring liver transplantation is rare. We present the case of a 14‐year‐old girl with SJS complicated by severe and rapidly progressive liver dysfunction, specifically, acute liver failure (ALF) requiring liver transplantation. A lymphocyte transformation test showed positive results for acetaminophen and cefdinir. Furthermore, human leukocyte antigen (HLA) genotyping revealed the presence of the HLA‐A*02:06 genotype, which is reported to be strongly associated with acetaminophen‐related SJS/TEN with severe ocular complications. These results suggested that our patient may have presented with acetaminophen‐induced SJS complicated by ALF, but no ocular complications. This is the first report of a pediatric patient with SJS who required liver transplantation. In rare instances, severe liver dysfunction requiring liver transplantation should be considered as a possible complication of SJS/TEN.
Type of Medium:
Online Resource
ISSN:
0385-2407
,
1346-8138
DOI:
10.1111/1346-8138.15963
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2222121-9
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