In:
Annual Review of Nutrition, Annual Reviews, Vol. 27, No. 1 ( 2007-08-01), p. 79-101
Abstract:
Lipolysis of white adipose tissue triacylglycerol stores results in the liberation of glycerol and nonesterified fatty acids that are released into the vasculature for use by other organs as energy substrates. In response to changes in nutritional state, lipolysis rates are precisely regulated through hormonal and biochemical signals. These signals modulate the activity of lipolytic enzymes and accessory proteins, allowing for maximal responsiveness of adipose tissue to changes in energy requirements and availability. Recently, a number of novel adipocyte triacylglyceride lipases have been identified, including desnutrin/ATGL, greatly expanding our understanding of adipocyte lipolysis. We have also begun to better appreciate the role of a number of nonenzymatic proteins that are critical to triacylglyceride breakdown. This review provides an overview of key mediators of lipolysis and the regulation of this process by changes in nutritional status and nutrient intakes.
Type of Medium:
Online Resource
ISSN:
0199-9885
,
1545-4312
DOI:
10.1146/nutr.2007.27.issue-1
DOI:
10.1146/annurev.nutr.27.061406.093734
Language:
English
Publisher:
Annual Reviews
Publication Date:
2007
detail.hit.zdb_id:
1481486-9
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