In:
International Journal of Cancer, Wiley, Vol. 136, No. 5 ( 2015-03)
Abstract:
What's new? Glioblastoma multiforme has a particularly grim prognosis. One potential treatment is “oncolytic virotherapy” (OVT), which relies on viruses that specifically infect and lyse tumor cells. In this study, the authors found that mice whose gliomas were injected with Newcastle‐disease virus (NDV) survived significantly longer than controls. Many researchers have assumed that, in order for OVT to work, the immune system must be suppressed. Here, however, NDV actually stimulated “immunogenic cell death” (ICD) and “necroptosis” (rather than apoptosis). OVT may thus be a promising therapeutic approach in combination with therapies that stimulate the immune response.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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