In:
Molecular Oncology, Wiley, Vol. 9, No. 1 ( 2015-01), p. 204-217
Abstract:
BRCA1 may regulate base excision repair (BER). BRCA1‐BER deficient cells may be sensitive to blockade of ATM and DNA‐PKcs. We show that low XRCC1/low pol β have prognostic significance in BRCA1−/− tumours. ATM or DNA‐PKcs inhibitors are synthetically lethal in BRCA1‐BER deficient cells. Synthetic lethality is enhanced in combination with cisplatin.
Type of Medium:
Online Resource
ISSN:
1574-7891
,
1878-0261
DOI:
10.1016/j.molonc.2014.08.001
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2322586-5
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