In:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, Vol. 156, No. 8 ( 2011-12), p. 969-974
Abstract:
Genetic variants in ankyrin 3 ( ANK3 ) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case–control sample (N = 854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case–control sample (N = 1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N = 435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N = 1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P = 0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P = 0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case–control sample (N = 1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved. © 2011 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1552-4841
,
1552-485X
DOI:
10.1002/ajmg.b.v156.8
DOI:
10.1002/ajmg.b.31244
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
2143866-3
SSG:
12
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