In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 8 ( 2021-8-23), p. e1009744-
Abstract:
Postzygotic isolation by genomic conflict is a major cause for the formation of species. Despite its importance, the molecular mechanisms that result in the lethality of interspecies hybrids are still largely unclear. The genus Drosophila , which contains over 1600 different species, is one of the best characterized model systems to study these questions. We showed in the past that the expression levels of the two hybrid incompatibility factors Hmr and Lhr diverged in the two closely related Drosophila species, D . melanogaster and D . simulans , resulting in an increased level of both proteins in interspecies hybrids. The overexpression of the two proteins also leads to mitotic defects, a misregulation in the expression of transposable elements and decreased fertility in pure species. In this work, we describe a distinct six subunit protein complex containing HMR and LHR and analyse the effect of Hmr mutations on complex integrity and function. Our experiments suggest that HMR needs to bring together components of centromeric and pericentromeric chromatin to fulfil its physiological function and to cause hybrid male lethality.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009744
DOI:
10.1371/journal.pgen.1009744.g001
DOI:
10.1371/journal.pgen.1009744.g002
DOI:
10.1371/journal.pgen.1009744.g003
DOI:
10.1371/journal.pgen.1009744.g004
DOI:
10.1371/journal.pgen.1009744.g005
DOI:
10.1371/journal.pgen.1009744.g006
DOI:
10.1371/journal.pgen.1009744.g007
DOI:
10.1371/journal.pgen.1009744.s001
DOI:
10.1371/journal.pgen.1009744.s002
DOI:
10.1371/journal.pgen.1009744.s003
DOI:
10.1371/journal.pgen.1009744.s004
DOI:
10.1371/journal.pgen.1009744.s005
DOI:
10.1371/journal.pgen.1009744.s006
DOI:
10.1371/journal.pgen.1009744.s007
DOI:
10.1371/journal.pgen.1009744.s008
DOI:
10.1371/journal.pgen.1009744.s009
DOI:
10.1371/journal.pgen.1009744.s010
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10.1371/journal.pgen.1009744.s011
DOI:
10.1371/journal.pgen.1009744.s012
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10.1371/journal.pgen.1009744.s013
DOI:
10.1371/journal.pgen.1009744.s014
DOI:
10.1371/journal.pgen.1009744.s015
DOI:
10.1371/journal.pgen.1009744.s016
DOI:
10.1371/journal.pgen.1009744.s017
DOI:
10.1371/journal.pgen.1009744.s018
DOI:
10.1371/journal.pgen.1009744.r001
DOI:
10.1371/journal.pgen.1009744.r002
DOI:
10.1371/journal.pgen.1009744.r003
DOI:
10.1371/journal.pgen.1009744.r004
DOI:
10.1371/journal.pgen.1009744.r005
DOI:
10.1371/journal.pgen.1009744.r006
DOI:
10.1371/journal.pgen.1009744.r007
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2186725-2
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