GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    RAISED IgM AUTOANTIBODY TITER TO LIPOPROTEIDE(A) AS ANTIATHEROGENIC FACTOR IN SEVERE HYPERCHOLESTEROLEMIA PATIENTS
    Silicea - Poligraf, LLC ; 2018
    In:  Russian Journal of Cardiology , No. 8 ( 2018-09-09), p. 13-20
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, , No. 8 ( 2018-09-09), p. 13-20
    Abstract: Aim. To investigate on the relation of lipoproteide(a) (Lpa), subfractions of atherogenic lipoproteides and titers of specific autoantibodies (autoAb) with the presence and severity of carotid arteries (CA) lesion in statin-naïve patients with severe hypercholesterolemia. Material and methods. To the study, 133 statin-naïve patients included, age 18 to 75 y.o., with absent clinical signs of coronary heart disease, and with first time diagnosed severe hypercholesterolemia (total cholesterol 〉 7,5 mM/L and/or low density lipoproteides cholesterol 〉 4,9 mM/L) with ultrasound duplex scan data of CA. All patients underwent measurement of Lpa concentration, lipid profile, subfractional content of apoB-100-containing lipoproteides and autoAb titer against them. Results. According to the data from duplex CA scan, patients were selected to 2 groups: control group (n=76) with no CA atherosclerosis; main group — patients with CA stenosis 〉 20% (n=57). The participants of main group were older than controls, with no other clinical or lipid profile differences. Titre of autoAb IgM specific for Lpa and its oxidized modifications was significantly lower in CA atherosclerosis comparing to controls. The grade of CA stenosis in severe hypercholesterolemia patients positively correlated with age (r=0,24, p=0,005) and negatively — with autoAb IgM to apoB100-containing lipoproteides (r=-0,28 and r=-0,26, p 〈 0,005). Also, a correlation found for CA stenosis grade with subfractions of intermediate density lipoproteides of moderate size (r=0,21, p=0,032). AutoAb titre against Lpa was an independent predictor of CA lesion severity regardless the age and traditional risk factors by the data from multifactorial regression. By ROCanalysis with the highest diagnostic value (square under AUC =0,68) the level of autoAb IgM to Lpa lower than 0,083 lab. units, with sensitivity 40% and specificity 88% is related to the lesion of common CA. Conclusion. In patients with severe hypercholesterolemia Lpa is an autoantigen, and IgM autoantibodies to Lpa play antiatherogenic role.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2018-8
    DOI: 10.15829/1560-4071-2018-8-13-20
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2018
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    CORRELATIONS OF LOW MOLECULAR WEIGHT PHENOTYPE OF APOPROTEIN(A) AND SERUM LEVEL OF LIPOPROTEIN(A) WITH MULTIFOCAL ATHEROSCLEROSIS IN PATIENTS WITH CORONARY HEART DISEASE
    Silicea - Poligraf ; 2010
    In:  Rational Pharmacotherapy in Cardiology Vol. 6, No. 4 ( 2010-01-01), p. 474-480
    Details
    In: Rational Pharmacotherapy in Cardiology, Silicea - Poligraf, Vol. 6, No. 4 ( 2010-01-01), p. 474-480
    Type of Medium: Online Resource
    ISSN: 2225-3653 , 1819-6446
    URL: Issue
    URL: Article
    DOI: 10.20996/1819-6446-2010-6-4
    DOI: 10.20996/1819-6446-2010-6-4-474-480
    Language: Unknown
    Publisher: Silicea - Poligraf
    Publication Date: 2010
    detail.hit.zdb_id: 2750390-2
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Lipoprotein(а) Level, Apolipoprotein(а) Polymorphism аnd Autoаntibodies Against Lipoprotein(а) in Patients with Stenotic Cаrotid Atherosclerosis
    APO Society of Specialists in Heart Failure ; 2019
    In:  Kardiologiia Vol. 59, No. 12 ( 2019-12-17), p. 20-27
    Details
    In: Kardiologiia, APO Society of Specialists in Heart Failure, Vol. 59, No. 12 ( 2019-12-17), p. 20-27
    Abstract: Аim. Comparative assessment of respiratory indicators according to multifunctional monitoring (PFM) with the recommended standard for a complete polysomnographic study and an assessment of the effect of blood pressure (BP) measurements in PFM on sleep quality. Triаls on the аssociаtion of Lp(а) and cаrotid аtherosclerosis аre limited. The аim of the study wаs to investigаte the аssociаtion of Lp(а), аpolipoprotein(а) [apo(а)] polymorphism аnd аutoаntibodies to Lp(а) with stenotic (≥50%) cаrotid аtherosclerosis in dependence on CHD presence. Materials and methods. The study included 785 pаtients аt the аge from 21 to 92 with dаtа of instrumentаl exаmination of coronаry, cаrotid аnd lower limbs аrteries. Stenotic cаrotid аtherosclerosis wаs diаgnosed in 447 pаtients who were divided into two groups depending on presence (n=344) or аbsence (n=103) of CHD. The control group comprised of 338 pаtients without stenotic аtherosclerosis of coronаry, cаrotid аnd lower limbs аrteries. In the blood serum of pаtients levels of Lp(а), аutoаntibodies to Lp(а) were determined аnd аlso аpo(а) phenotyping wаs conducted. Results. There were more mаles, higher аverаge аge аnd frequency of hypertension, type 2 diаbetes mellitus, smoking, Lp(а) concentrаtion (mediаn [interquаrtile rаnge]): 30 [11; 63] vs. 14 [5; 30] mg/dl, p 〈 0.01) in the group with stenotic cаrotid аtherosclerosis in compаrison with control group. Besides, Lp(а) level wаs higher in CHD subgroup thаn in pаtients with stenotic cаrotid аtherosclerosis without CHD: 32 [12; 72] vs. 24 [8; 50] mg/dl, respectively, p=0.01. Elevаted (≥30 mg/dl) Lp(а) level, low moleculаr weight аpolipoprotein(а) [(LMW аpo(а)] phenotype were аssociаted with stenotic cаrotid аtherosclerosis (odds rаtio (OR) 2.9; 95% confidence intervаl (CI) 2.1–4.0, p 〈 0.01 аnd OR 2.3; 95% CI 1.6–3.4, p 〈 0.01, respectively). Logistic regression аnаlysis showed independent аssociаtion of elevаted Lp(а) level аnd LMW аpo(а) phenotype with stenotic cаrotid аtherosclerosis both in the presence аnd absence of CHD. The level of IgM аutoаntibodies to Lp(а) wаs higher in control group thаn in pаtients with stenotic cаrotid аtherosclerosis, p=0.02. Conclusion The level of Lp(a) ≥30 mg/dl and low molecular weight phenotype of aprotein(a) are predictors of stenotic atherosclerosis CA, regardless of the presence of coronary heart disease and other risk factors, while a reverse relationship was found between the level of autoantibodies of the IgM class against Lp(a) and the severity of atherosclerosis CA.
    Type of Medium: Online Resource
    ISSN: 2412-5660 , 0022-9040
    URL: Article
    DOI: 10.18087/cardio.2019.12.n727
    Language: Unknown
    Publisher: APO Society of Specialists in Heart Failure
    Publication Date: 2019
    detail.hit.zdb_id: 3005439-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Association of lipoprotein (a) with ischemic stroke and stenotic carotid atherosclerosis
    Media Sphere Publishing Group ; 2020
    In:  Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova Vol. 120, No. 3 ( 2020), p. 42-
    Details
    In: Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, Media Sphere Publishing Group, Vol. 120, No. 3 ( 2020), p. 42-
    Type of Medium: Online Resource
    ISSN: 1997-7298
    URL: Article
    DOI: 10.17116/jnevro202012003242
    Language: Russian
    Publisher: Media Sphere Publishing Group
    Publication Date: 2020
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Severe hyperlipoproteinemia(a) as a factor of rapidly progressive coronary artery disease in a young woman with heterozygous familial hypercholesterolemia
    Silicea - Poligraf, LLC ; 2019
    In:  Russian Journal of Cardiology , No. 5 ( 2019-06-14), p. 72-73
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, , No. 5 ( 2019-06-14), p. 72-73
    Abstract: .
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2019-5
    DOI: 10.15829/1560-4071-2019-5-72-73
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2019
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    INFLUENCE OF NICOTINIC ACID ON SUBFRACTIONAL SPECTRUM OF LOW, INTERMEDIATE AND HIGH DENSITY LIPOPROTEINS IN PATIENTS WITH HYPERLIPOPROTEINEMIA(а)
    Silicea - Poligraf, LLC ; 2017
    In:  Russian Journal of Cardiology , No. 5 ( 2017-01-01), p. 91-96
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, , No. 5 ( 2017-01-01), p. 91-96
    Type of Medium: Online Resource
    ISSN: 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2017-5
    DOI: 10.15829/1560-4071-2017-5-91-96
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2017
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Lipoprotein(a) concentration and the blood content of INFγ-producing T-helpers 17 (Th17/1) in males with premature coronary artery disease
    Silicea - Poligraf, LLC ; 2022
    In:  Russian Journal of Cardiology Vol. 27, No. 6 ( 2022-05-06), p. 5046-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 27, No. 6 ( 2022-05-06), p. 5046-
    Abstract: Aim . To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD). Material and methods . This retrospective cross-sectional study included 76 men aged 40 to 79 years. Patients were divided into following groups: main group — patients with CAD (58 [54;64] years, n=56) onset before the age of 55; control group — patients (62 [57;66] years, n=20) without CAD and obstructive CAD and peripheral arterial disease. Statins were taken by 51 (91%) and 9 (45%) patients in the main and control groups, respectively. In serum and plasma samples, lipid spectrum parameters and Lp(a) concentration were determined. Cellular phenotyping was performed by direct immunofluorescence in a culture of mononuclear leukocytes isolated from blood. To determine cytokines, cells were in vitro activated with inhibitor of intracellular transport of secretory proteins. Cell fluorescence was determined using flow cytometry. Results . Patients of both groups were comparable in age, body mass index, prevalence of hypertension and diabetes. Blood Lp(a) concentrations were higher in the CAD group than in the control group (49 [10;102] mg/dL vs 12 [4,3;32] mg/ dL, p 〈 0,05). The content of INFγ-producing T-helpers 17 (Th17/1) was also higher in the CAD group (19 [15;24] vs 13 [11;22] , % of Th17, p=0,05). Logistic regression revealed that elevated Lp(a) levels (≥30 mg/dL) and relative amounts of Th17/1 ( 〉 14% of Th17) independently of each other, atherogenic lipoprotein cholesterol levels, classical risk factors, and statin use were associated with premature CAD in the general group of patients with odds ratio (OR) of 4,6 (95% confidence interval (CI), 1,1-20,2) and 10,9 (2,1-56,7), p 〈 0,05, respectively. The combination of Lp(a) 〉 30 mg/dl and Th17/1 over 14% significantly increased the risk of premature CAD (OR, 28,0, 95% CI, 4,31-181,75, p=0,0005). Conclusion . We have shown for the first time that an increased Lp(a) concentration with an increased Th17/1 content is associated with the premature CAD in men.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2022-6
    DOI: 10.15829/1560-4071-2022-5046
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2022
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    The Association of Lipoprotein(a), Apolipoprotein(a) Phenotypes and Autoantibodies to Lipoprotein(a) With Lower Extremity Artery Disease
    APO Society of Specialists in Heart Failure ; 2018
    In:  Kardiologiia Vol. 58, No. 12 ( 2018-12-25), p. 45-51
    Details
    In: Kardiologiia, APO Society of Specialists in Heart Failure, Vol. 58, No. 12 ( 2018-12-25), p. 45-51
    Abstract: Aim . Lipoprotein(a) [Lp(a)] and low molecular weight (LMW) apolipoprotein(a) [apo(a)] phenotype are risk factors of сoronary heart disease and stroke. Data about the role of Lp(a) and phenotypes apo(a) in the development of lower extremity artery disease (LEAD) is scarce. The aim of our study was to assess the association of Lp(a), apo(a) phenotypes and autoantibodies to apolipoprotein B100 (apoB100) lipoproteins with LEAD. Materials and methods . The study included 622 patients (386 male and 236 female, average age 61±12 years), examined in the Department of Atherosclerosis of National Medical Research Center of Cardiology. Patients were divided into 2 groups: the main group included 284 patients with LEAD, 338 patients without significant atherosclerosis of coronary, carotid and lower limbs arteries formed the control group. LEAD was diagnosed as atherosclerotic lesions with at least one stenosis of low limb artery ≥50 % and ankle­brachial index ≤0.9. The concentration of Lp(a), lipids was measured in blood serum of all the patients, level of autoantibodies to apoB100 lipoproteins was measured in 247 patients, and apo(a) phenotypes were determined in 389 patients. Results. Patients with LEAD were older, were more frequently male, and had a greater prevalence of risk factors including hypertension, type 2 diabetes, smoking than the control group patients (p 〈 0.001 in all the cases). The level of Lp(a) was significantly higher in the main group compared to control group: 35 [14; 67] mg / dl vs. 14 [5; 32] mg / dl, p 〈 0,001. ROC analysis demonstrated that the level of Lp(a) ≥26 mg / dl was associated with LEAD (sensitivity 61 %, specificity 70 %). The prevalence of Lp(a) ≥26 mg / dl and LMW apo(a) phenotype were higher in the main group in comparison with the control group: 61 % vs. 30 % and 48 % vs. 26 % respectively (p 〈 0.001 in the both cases). The odds ratio of LEAD in the presence of Lp(a) ≥26 mg / dl was 3.7 (95 % confidence interval (CI), 2.6–5.1, p 〈 0.001) and in the presence of LMW apo(a) phenotype was 2.6 (95 % CI, 1.7–4.0, p 〈 0.001). In logistic regression analysis adjusted for age, sex, hypertension, smoking, diabetes, both Lp(a) and LMW apo(a) phenotype were independent predictors of LEAD when included separately. The level of IgM autoantibodies to Lp(a) was significantly higher in the control group compared to the patients with LEAD (p=0.01). Concentration of IgG autoantobodies to Lp(a) and LDL in the plasma did not differ essentially in the both groups. Conclusion. The level of Lp(a) ≥26 mg / dl and LMW apo(a) phenotype are independent predictors of LEAD, whereas the contribution of autoantobodies to Lp(a) in LEAD development is controversial.
    Type of Medium: Online Resource
    ISSN: 2412-5660 , 0022-9040
    URL: Article
    DOI: 10.18087/cardio.2018.12.10176
    Language: Unknown
    Publisher: APO Society of Specialists in Heart Failure
    Publication Date: 2018
    detail.hit.zdb_id: 3005439-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    The Relationship of the Concentration of Lipoprotein(a) and Markers of Inflammation with Multifocal Atherosclerosis in Women
    APO Society of Specialists in Heart Failure ; 2019
    In:  Kardiologiia Vol. 59, No. 10 ( 2019-10-15), p. 39-48
    Details
    In: Kardiologiia, APO Society of Specialists in Heart Failure, Vol. 59, No. 10 ( 2019-10-15), p. 39-48
    Abstract: Purpose : to study relationship of lipoprotein(a) [Lp(a)], indicators of systemic inflammation and humoral immunity with severity of atherosclerotic involvement of various vascular beds in women. Materials and methods . We included in this study 148 women aged 69±11 years with results of instrumental investigation of coronary, carotid arteries, and arteries of lower extremities. According to results of coronary angiography and ultrasound study patients were distributed into two groups: with stenosing atherosclerosis (those with hemodynamically significant [ 〉 50%] atherosclerotic lesions in any of these vascular beds, n=108), and control (those without hemodynamically significant stenoses, n=40). In dependence of extent of athe rosclerotic involvement patients with stenosing atherosclerosis were divided into subgroups: with lesions in one vascular bed (subgroup 1, n=44) and with lesions in two and more vascular beds (subgroup 2, n=64). All patients with stenosing atherosclerosis and 78% of control patients took statins. In all patients we measured lipid spectrum, Lp(a) concentration, C-reactive protein (CRP). Preparations of oxidized lipoproteins [oxLp(a)] were obtained by Cu 2+ -induced free radical oxidation at 37 °С for 3 hours. Titer of autoantibodies to Lp(a), LDL and their oxidized modifications was determined by enzyme-linked immunosorbent assay (ELISA). Concentration of low-density lipoprotein cholesterol corrected on cholesterol in Lp(a) (LDLCh corr) was calculated by Dahlen modification of Friedewald formula. Results. Stenosing atherosclerosis was diagnosed in 60 of 74 women (80%) with Lp(a) concentration above median - 33 mg/dl (in 38 multifical). Increase of blood serum Lp(a) concentration was associated with presence of isolated as well as multifocal atherosclerosis according to unifactorial, multifactorial, and logistic analysis, irrespective of other factors of risk and indicators of inflammation. According to results of logistic regression analysis increase of Lp(a) concentration by 1 mg/dl was associated with 1 % elevation of probability of appearance and development of multifocal atherosclerosis in women. Low level of class IgM autoantibodies to Lp(a) was linked with detection of stenosing atherosclerosis in any of 3 vascular beds (1 st vs. 4 th quartile of IgM autoantibodies concentration - OR 7.6., 95%CI 1.9-29.4; р=0.004) and had diagnostic significance. Indicators of systemic inflammation such as CRP and circulating immune complexes were high and had diagnostic significance for detection of multifocal atherosclerosis in studied women. However none of indicators was predictor of appearance of stenosing atherosclerosis according to data of logistic regression analysis. Conclusion. Elevated concentration of Lp(a) is an independent predictor of risk of development stenosing atherosclerosis in various vascular beds and appearance of multifocal irrespective of other risk factors, indicators of systemic inflammation, and factors of humoral immunity in women. Markers of inflammation, as well as IgM autoantibodies against Lp(a) have diagnostic value for detection of patients stenosing lesions ib one or several vascular beds.
    Type of Medium: Online Resource
    ISSN: 2412-5660 , 0022-9040
    URL: Article
    DOI: 10.18087/cardio.2019.10.n520
    Language: Unknown
    Publisher: APO Society of Specialists in Heart Failure
    Publication Date: 2019
    detail.hit.zdb_id: 3005439-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    SUBFRACTIONS OF ATHEROGENIC APOB-LIPOPROTEIDES IN PATIENTS WITH SEVERE HYPERCHOLESTEROLEMIA
    Silicea - Poligraf, LLC ; 2017
    In:  Cardiovascular Therapy and Prevention Vol. 16, No. 4 ( 2017-01-01), p. 45-49
    Details
    In: Cardiovascular Therapy and Prevention, Silicea - Poligraf, LLC, Vol. 16, No. 4 ( 2017-01-01), p. 45-49
    Type of Medium: Online Resource
    ISSN: 1728-8800
    URL: Issue
    URL: Article
    DOI: 10.15829/1728-8800-2017-4
    DOI: 10.15829/1728-8800-2017-4-45-49
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2017
    detail.hit.zdb_id: 3032202-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...