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  • 1
    Online Resource
    Online Resource
    ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications
    Society of Pharmaceutical Tecnocrats ; 2022
    In:  Journal of Drug Delivery and Therapeutics Vol. 12, No. 2-S ( 2022-04-15), p. 127-141
    Details
    In: Journal of Drug Delivery and Therapeutics, Society of Pharmaceutical Tecnocrats, Vol. 12, No. 2-S ( 2022-04-15), p. 127-141
    Abstract: Cuminum cyminum L (Family: Apiaceae) is a small multipurpose herb. Seeds of cumin are widely used as a spice for its distinctive aroma, and more commonly in various indigenous traditional systems of medicine. Access through web literature provides ample evidence for biomedical activities of Cuminum cyminum seeds (CCS). CCS has been used in traditional medicine to treat variety of diseases, including hypolipidemia, cancer, and diabetes. Biomedical properties of CCS is attributed to its phytochemical class of compounds viz., terpenes, phenols and flavonoids. Health effects of CCS have been experimentally validated through phytochemical screening deciphering the fact that it contains a large number of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinones, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Furthermore, pharmacological studies indicate that BASMs in CCS exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. Cuminaldehyde is one of the major bioactive compounds in CCS that holds significant pharmacological prominence. However, in-depth studies are lacking henceforth warranted to elucidate and fill the gaps, particularly on phytocompound isolation, pre-clinical, clinical characterization, and evaluation of structure–activity relationship. The present study prospects ADMETox perspectives of cuminaldehyde (4-Isopropylbenzaldehyde). Keywords: Cuminaldehyde; Isopropylbenzaldehyde; Cuminum cyminum; ADMETox; Natural Product (NP)
    Type of Medium: Online Resource
    ISSN: 2250-1177
    URL: Article
    DOI: 10.22270/jddt.v12i2-S.5286
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2022
    detail.hit.zdb_id: 2767921-4
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  • 2
    Online Resource
    Online Resource
    Reformulation and Scientific Evaluation of CUSOCO: A Traditional Toothpaste Formula from Classical Tamil Literature towards treatment of Halitosis
    Society of Pharmaceutical Tecnocrats ; 2022
    In:  Journal of Drug Delivery and Therapeutics Vol. 12, No. 5 ( 2022-09-15), p. 127-131
    Details
    In: Journal of Drug Delivery and Therapeutics, Society of Pharmaceutical Tecnocrats, Vol. 12, No. 5 ( 2022-09-15), p. 127-131
    Abstract: In order to achieve the multi-claim products required for dental-health-care and hygiene, it is indispensable for the formulator to use a wide range of ingredients however, with the advent of technology the chemically synthesised products are not of demand in the market as they have side effects and are considered to unsafe for human use. This places quite a number of demands on the use of PBNPs in the development process. Use of PBNPs innovations in the areas of pharmaceutical technology have contributed significantly to the formulation of dental-health-care products with superior efficacy as well as other attributes that may contribute to clinical response and patient acceptability. Improved clinical efficacy and tolerability, along with conditioning signals, should encourage patient compliance with oral hygiene. Cuminum cyminum seeds are being habitually used in traditional cuisines of different cultures. In India, it is used in both whole and ground form as a traditional ingredient to make dishes without perceptive medicinal knowledge/ properties behind. In Kerala, decoction of cumin seeds is used for drinking (Jeera water). In Tamilnadu, cumin seeds are the key ingredient of Rasam. Fruit of Solanum lycopersicum is one of the important savoury vegetable used in traditional Indian cuisines. The oil of Cocos nucifera fruits are used in cooking in Kerala and TamilNadu. In the present study, composition (paste) prepared by mixing of 2 drops of S. lycopersicum fruit juice, 2 drops of C. nucifera and 1g of C. cyminum seed powder were tested on 100 subjects with felt bad breath. Results of the present study was found to be effective in controlling bad breath (odour) in 74 subjects after the treatment (period of clinical trial) except 09 of 83 subjects who were diabetic. Keywords: Oral hygiene; bad breath; halitosis; Cuminum cyminum; Solanum lycopersicum; Cocos nucifera; CUSOCO; dental-health-care
    Type of Medium: Online Resource
    ISSN: 2250-1177
    URL: Article
    DOI: 10.22270/jddt.v12i5.5604
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2022
    detail.hit.zdb_id: 2767921-4
    SSG: 15,3
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  • 3
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    Online Resource
    ADMET-informatics, Pharmacokinetics, Drug-likeness and Medicinal Chemistry of Bioactive Compounds of Physalis minima Ethanolic Leaf Extract (PMELE) as a Potential Source of Natural Lead Molecules for Next Generation Drug Design, Development and Therapies
    Society of Pharmaceutical Tecnocrats ; 2022
    In:  Journal of Drug Delivery and Therapeutics Vol. 12, No. 5 ( 2022-10-15), p. 188-200
    Details
    In: Journal of Drug Delivery and Therapeutics, Society of Pharmaceutical Tecnocrats, Vol. 12, No. 5 ( 2022-10-15), p. 188-200
    Abstract: Physalis minima (PM) belongs to the family Solanaceae. PM has been traditionally used to cure and prevent several disorders as documented in Vedic Texts. Nevertheless, scientific values of traditional claims haven't been explored yet. In the previous study, GCMS analysis of P. minima ethanolic leaf extracts (PMELE) indicated the presence of Cyclobutanol (C4H8O); D-Alanine (C3H7O2N); 2-Heptanol, 6-Amino-2-Methyl (C8H19ON); 1-Pentanol, 4-Amino (C5H13NO); Benzeneethanamine, 3-Fluoro-Beta.,5-Dihydroxy-N-Methyl (C9H12FNO2) and L-Alanine, N-(N-Acetylglycyl)-, Butyl Ester (C11H20N2O4). However, biological activities of these bioactive compounds are not known which hampers the exploitation of these compounds by pharma-industries on a commercial scale. This study on ADMET, Pharmacokinetics, Drug-likeness and Medicinal Chemistry of Bioactive Compounds in PMELE aims to provide baseline information on PBNPs as a potential source of natural lead molecules for next generation drug design, development and therapeutics. Keywords: PM-PBNPs; ADMET; PMELE; Pharmacokinetics; Drug-likeness; Drug Development; Bioactive Compounds
    Type of Medium: Online Resource
    ISSN: 2250-1177
    URL: Article
    DOI: 10.22270/jddt.v12i5.5654
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2022
    detail.hit.zdb_id: 2767921-4
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  • 4
    Online Resource
    Online Resource
    Profile of Phytochemicals and GCMS Analysis of Bioactive Compounds in Natural Dried-Seed Removed Ripened Pods Methanolic Extracts of Moringa oleifera
    Society of Pharmaceutical Tecnocrats ; 2022
    In:  Journal of Drug Delivery and Therapeutics Vol. 12, No. 5-S ( 2022-10-15), p. 133-141
    Details
    In: Journal of Drug Delivery and Therapeutics, Society of Pharmaceutical Tecnocrats, Vol. 12, No. 5-S ( 2022-10-15), p. 133-141
    Abstract: Moringa oleifera has been reported to be the store-house of wide range of bioactive compounds. Most commonly used plant part has been the leaves which are reported to be rich in Vitamins, Carotenoids, Polyphenols, Phenolic Acids, Flavonoids Alkaloids, Glucosinolates, Isocyanides, Tannins and Saponins. Moringa leaves are used as Keerai while, green pods are commonly used as vegetable in the traditional preparation of Sambar in South-India. MO is gaining popularity because of its nutrient-rich root, leaves, flowers and fruits, having immense traditional medicinal uses and proved pharmacological properties. Not much of work has been carried out on analysis of bioactive compounds present in the pods. In the present study an attempt has been made to screen and analyze the range of bioactive compounds present in Moringa oleifera seed removed ripened natural dried pods. Phytochemical screening and GCMS analysis revealed the presence of 12 compounds namely - 7-Octadecyne, 2-methyl- (C19H36); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); 6,9,12,15-Docosatetraenoic acid, me (C23H38O2); Cyclohexanol, 5-methyl-2-(1-methylethyl)- (C10H20O); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); Palmitic acid vinyl ester (C18H34O2); .gamma.-Tocopherol (C28H48O2); Vitamin E (C29H50O2); Cholesta-7,9(11)-dien-3-ol, 4,4-dim (C29H48O); gamma.-Sitosterol (C29H50O); Stigmasta-5,24(28)-dien-3-ol, (3.beta.,24Z)- (C29H48O). Further, in-silico ADMET analysis is expected to provide in-death physiochemical and biomolecular details of these molecules in order to exploit them for production of novel drugs for the pharma market with wide array of bio medical applications. Keywords: Bioactive Compounds; GCMS; Phytochemical Screening; MOPME; Plant Based Natural Products;
    Type of Medium: Online Resource
    ISSN: 2250-1177
    URL: Article
    DOI: 10.22270/jddt.v12i5-S.5657
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2022
    detail.hit.zdb_id: 2767921-4
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    ADMETox-informatics of Plant Derived Octadecanoic Acid (Stearic Acid) from Ethyl Acetate Fraction of Moringa oleifera Leaf Extract as a Natural Lead for Next Generation Drug Design, Development and Therapeutics
    Society of Pharmaceutical Tecnocrats ; 2022
    In:  Journal of Drug Delivery and Therapeutics Vol. 12, No. 6 ( 2022-11-15), p. 129-141
    Details
    In: Journal of Drug Delivery and Therapeutics, Society of Pharmaceutical Tecnocrats, Vol. 12, No. 6 ( 2022-11-15), p. 129-141
    Abstract: In-silico Computer-Aided Drug Design (CADD) significantly relies on cybernetic screening of Plant Based Natural Products (PBNPs) as a prime source of bioactive compounds/ drug leads due to their unique chemical structural scaffolds and distinct functional characteristic features amenable to drug design and development. In the Post-COVID-Era a large number of publications have focused on PBNPs. Moreover, PBNPs still remain as an ideal source of novel therapeutic agents of GRAS standard. However, a well-structured, in-depth ADME/Tox profile with deeper dimensions of PBNPs has been lacking for many of natural pharma lead molecules that hamper successful exploitation of PBNPs. In the present study, ADMET-informatics of Octadecanoic Acid (Stearic Acid - SA) from ethyl acetate fraction of Moringa oleifera leaves has been envisaged to predict ADMET and pharmacokinetics (DMPK) outcomes. This work contributes to the deeper understanding of SA as major source of drug lead from Moringa oleifera with immense therapeutic potential. The data generated herein could be useful for the development of SA as plant based natural product lead (PBNPL) for drug development programs. Keywords: Moringa oleifera; Bioactive Substances; Octadecanoic Acid; Stearic Acid; ADME/Tox; Natural Product Based Drug Lead; PBNPs
    Type of Medium: Online Resource
    ISSN: 2250-1177
    URL: Article
    DOI: 10.22270/jddt.v12i6.5677
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2022
    detail.hit.zdb_id: 2767921-4
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  • 6
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    Online Resource
    ADMET-Evaluation, Pharmacokinetics, Drug-likeness and Medicinal Chemistry of GCMS Identified Bioactive Compounds of Moringa oleifera Natural-Ripened-Dried Methanolic Pod Extract (MOMPE) as a Potential Source of Natural Drug Frontrunner for Next Generation
    Society of Pharmaceutical Tecnocrats ; 2022
    In:  Journal of Drug Delivery and Therapeutics Vol. 12, No. 6 ( 2022-11-15), p. 65-85
    Details
    In: Journal of Drug Delivery and Therapeutics, Society of Pharmaceutical Tecnocrats, Vol. 12, No. 6 ( 2022-11-15), p. 65-85
    Abstract: Over centuries, Moringa oleifera has been used as an integral part of Ayurveda, Siddha and Unani systems of medicine, besides this miracle tree has a wide range of nutritional and bioactive compounds, including proteins, essential amino acids, carbohydrates, lipids, fiber, vitamins, minerals, phenolic compounds, phytosterols and others. The miracle tree is endowed with a wide range of pharmacological properties, including anti-diabetic, anti-inflammatory, anti-carcinogenic, antioxidant, cardioprotective, antimicrobial and hepatoprotective activities. However, deeper dimensions of authentic data on plant based natural products in relation to drug discovery, pharmacokinetics properties of biomolecules is far lacking. ADMET prospecting is eventually expected to contribute to success of MO based lead candidates in drug design, development program besides saving time and money. This study is the first of its kind reporting summative ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicology) properties of all bioactive compounds Moringa oleifera methanolic pod extract (MOMPE) as a potential source of natural drug lead using Swiss ADME. A total of 12 compounds namely - 7-Octadecyne, 2-methyl- (C19H36); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); 6,9,12,15-Docosatetraenoic acid, me (C23H38O2); Cyclohexanol, 5-methyl-2-(1-methylethyl)- (C10H20O); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); Palmitic acid vinyl ester (C18H34O2); .γ.-Tocopherol (C28H48O2); Vitamin E (C29H50O2); Cholesta-7,9(11)-dien-3-ol, 4,4-dim (C29H48O); γ.-Sitosterol (C29H50O); Stigmasta-5,24(28)-dien-3-ol, (3.β.,24Z)- (C29H48O). Most of the MOPBNPs are non-substrate for both P-gp (P-glycoprotein) and CYP (Cytochrome P-450 isoenzymes). All the compounds were evaluated for properties viz., GI absorption, BBB permeant, Pgp substrate, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4 inhibitors, Lipinski, Ghose, Veber, Egan, Muegge, rule and Bioavailability Score to provide baseline information on PBNPs in MONRD pod. Keywords: PBNPs; NGDDT; ADMET; Moringa oleifera; Secondary Metabolites MONRD pod
    Type of Medium: Online Resource
    ISSN: 2250-1177
    URL: Article
    DOI: 10.22270/jddt.v12i6.5668
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2022
    detail.hit.zdb_id: 2767921-4
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Artificial Intelligence and Machine Learning approach based in-silico ADME-Tox and Pharmacokinetic Profile of α-Linolenic acid from Catharanthus roseus (L.) G. Don.
    Society of Pharmaceutical Tecnocrats ; 2022
    In:  Journal of Drug Delivery and Therapeutics Vol. 12, No. 2-S ( 2022-04-15), p. 96-109
    Details
    In: Journal of Drug Delivery and Therapeutics, Society of Pharmaceutical Tecnocrats, Vol. 12, No. 2-S ( 2022-04-15), p. 96-109
    Abstract: Current craze and concomitant rise of Artificial Intelligence and Machine Learning (AI & ML) in the post-COVID-era holds significant contribution to Drug Design and Development. Along with IoT, AI & ML has reduced human interface and improved the Quality of Life though Quality-Health-Care products. AI & ML approaches driven Rational Drug Design along with customised molecular modelling techniques such as in-silico simulation, pharmacophore modelling, molecular dynamics, virtual screening, and molecular docking aims to elucidate unforeseen bioactivity of natural products confined to limited timeframe with at-most perfection. Besides, it also defines the molecular determinants that partake in the interface with in the drug and the target to design more proficient drug leads. α-Linolenic acid (ALA), a carboxylic acid with 18 carbons and three cis double bonds, is an essential fatty acid required for normal human health and can be acquired through regular dietary supplementation of food. During the metabolic process, ALA is bio-transformed into EPA and DHA. ALA decreases the risk of heart disease by maintaining normal heart rhythm and pumping. Studies suggest that ALA is associated with reduced risk of fatal ischemic heart disease further higher intake may reduce the risk of sudden death among prevalent myocardial infarction patients consistent with induced antiarrhythmic effect. It reduces blood clots, besides, cardiovascular-protective, anti-cancer, neuro-protective, anti-osteoporotic, anti-inflammatory, and anti-oxidative effects. However, data on pharmacological and toxicological aspects of ALA is limited; on the other hand, no serious adverse effects of ALA have been reported yet. In the present study AI & ML approach based in-silico ADME-Tox and pharmacokinetic profile of ALA from Catharanthus roseus is envisaged. Keywords: IoT; AI & ML; ADME-Tox; α-Linolenic Acid (ALA); EPA; DHA Pharmacokinetics; Catharanthus roseus.
    Type of Medium: Online Resource
    ISSN: 2250-1177
    URL: Article
    DOI: 10.22270/jddt.v12i2-S.5274
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2022
    detail.hit.zdb_id: 2767921-4
    SSG: 15,3
    Location Call Number Limitation Availability
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