In:
Chemistry – A European Journal, Wiley, Vol. 25, No. 8 ( 2019-02-06), p. 2019-2024
Abstract:
Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template‐based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia‐inducible transcription factor prolyl hydroxylase, PHD2.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201804790
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1478547-X
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