In:
Obesity, Wiley, Vol. 26, No. 7 ( 2018-07), p. 1234-1241
Abstract:
This study examined the associations of muscle area and radiodensity with adiponectin and leptin. Methods A total of 1,944 participants who enrolled in the Multi‐Ethnic Study of Atherosclerosis underwent computed tomography to quantify body composition and measurements of adiponectin, leptin, interleukin‐6, C‐reactive protein, and resistin. Results The mean age and BMI of participants were 64.7 years and 28.1 kg/m 2 and 49% were female. With adjustment for age, gender, race/ethnicity, traditional cardiovascular disease risk factors, inflammatory biomarkers, physical activity, and sedentary behavior, a 1‐SD increment in total abdominal, stability, and locomotor muscle area was associated with a 19%, 17%, and 12% lower adiponectin level, respectively ( P 〈 0.01 for all) but not leptin ( P 〉 0.05). Muscle radiodensity was more robustly associated with adiponectin and leptin in the multivariable linear regression models. That is, with full adjustment for all covariates, a 1‐SD increment in total abdominal, stability, and locomotor muscle radiodensity was associated with a 31%, 31%, and 18% lower adiponectin level ( P 〈 0.01 for all) and a 6.7%, 4.6%, and 8.1% higher leptin level ( P 〈 0.05 for all), respectively. Conclusions The data suggest that increases in muscle area and radiodensity may have positive impacts on chronic inflammation and, in turn, reduce the risk of cardiometabolic disease.
Type of Medium:
Online Resource
ISSN:
1930-7381
,
1930-739X
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2027211-X
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