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  • 1
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 141, No. Suppl_1 ( 2020-03-03)
    Abstract: Introduction: Fat infiltration into muscle reduces muscle density and increases the risk for metabolic dysfunction, mobility disability and mortality. We assessed abdominal muscle density and muscle area in relation to incident coronary heart disease (CHD) events. Methods: Adults (mean age 64.6 ± 9.6) from the Multi-Ethnic Study of Atherosclerosis body composition ancillary study had computed tomography (CT)-derived measures of muscle density, muscle area and visceral fat at the L2-L4 spinal column levels between 2002-05 and were followed for incident events. Using sex-stratified Cox proportional hazards regression, associations of muscle density and muscle area (in the same model) with CHD events were assessed using restricted cubic splines with adjustment for confounders including visceral adiposity and BMI. Results: After 10.3±2.9 years of follow up, 924 males had 70 CHD (7.6%) events and 945 females had 44 CHD (4.7%) events. Muscle density was higher in males (44.5±4.9 HU) than females (40.1±5.2 HU), as was muscle area (116.7±23.9 vs. 80.4±23.9 cm 2 , respectively). Among males, and in mutually adjusted models, each incremental SD of muscle density was inversely associated with CHD (HR=0.67; 95%CI=0.49-0.92), while each SD of muscle area was associated with higher risk of CHD (HR=1.75; 95%CI=1.34-2.28; Figure). Overall patterns were similar but less strong among females for density (HR=0.79; 95%CI=0.50-1.22) and area (HR=1.17; 95%CI=0.79-1.73). Conclusions: Greater muscle density is associated with lower CHD risk, while greater muscle size is associated with increased CHD risk. These associations were independent of traditional CHD risk factors and measures of visceral and total body adiposity. Quantity and quality of skeletal muscle may represent distinct aspects of aging and physical functioning that are important in heart health.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 1466401-X
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  • 2
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2014
    In:  Medicine & Science in Sports & Exercise Vol. 46 ( 2014-05), p. 651-
    In: Medicine & Science in Sports & Exercise, Ovid Technologies (Wolters Kluwer Health), Vol. 46 ( 2014-05), p. 651-
    Type of Medium: Online Resource
    ISSN: 0195-9131
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2014
    detail.hit.zdb_id: 2031167-9
    SSG: 31
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  • 3
    Online Resource
    Online Resource
    Elsevier BV ; 2018
    In:  Physiology & Behavior Vol. 196 ( 2018-11), p. 211-217
    In: Physiology & Behavior, Elsevier BV, Vol. 196 ( 2018-11), p. 211-217
    Type of Medium: Online Resource
    ISSN: 0031-9384
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2008755-X
    SSG: 12
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  • 4
    In: Journal of Physical Activity and Health, Human Kinetics, Vol. 15, No. 11 ( 2018-11-1), p. 827-833
    Abstract: Background : Sedentary behaviors (SB) may exacerbate loss of muscle mass and function, independent of physical activity levels. This study examined the associations of SB with abdominal muscle area and density, a marker of muscle quality, in adults. Methods : A total of 1895 participants from the Multi-Ethnic Study of Atherosclerosis completed detailed health history, physical activity and SB questionnaires, computed tomography to quantify body composition, and measurements of inflammatory markers. Analyses included linear and nonlinear regression. Results : The mean age and body mass index were 64.6 years and 28 kg·m −2 , respectively, and 50% were women. On average, participants engaged in 28 metabolic equivalent hours·week −1 of SB. With adjustment for age, sex, race/ethnicity, physical activity, cardiovascular disease risk factors, and inflammation, multivariable regression modeling revealed a nonlinear (quadratic) relationship between SB and locomotor, stability, and total abdominal muscle density ( P   〈  .01) but not muscle area. The SB inflection point at which locomotor, stability, and total abdominal muscle density began to decrease was 38.2, 39.6, and 39.2 metabolic equivalent hours·week −1 of SB, respectively. Conclusions : SB is associated with reduced muscle density when practiced as little as 5.5 metabolic equivalent hours·day −1 . These findings may have important implications for SB guidelines for targeting skeletal muscle health in older adults.
    Type of Medium: Online Resource
    ISSN: 1543-3080 , 1543-5474
    Language: Unknown
    Publisher: Human Kinetics
    Publication Date: 2018
    SSG: 31
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  • 5
    Online Resource
    Online Resource
    Human Kinetics ; 2022
    In:  Journal of Physical Activity and Health Vol. 19, No. 4 ( 2022-04-1), p. 256-266
    In: Journal of Physical Activity and Health, Human Kinetics, Vol. 19, No. 4 ( 2022-04-1), p. 256-266
    Abstract: Background: Using data from a multiethnic cohort, the authors tested associations of multiple types and intensities of physical activity (PA) with abdominal muscle area and density. Methods: 1895 Multiethnic Study of Atherosclerosis participants (mean age 64.6 [9.6] y) completed health history and PA questionnaires and computed tomography to quantify body composition and measurements of cardiovascular and inflammatory biomarkers. Analyses included multivariable regression. Results: Compared with those not meeting PA guidelines for Americans, those meeting the guidelines had higher total abdominal muscle area (odds ratio, 95% confidence interval 1.60, 1.20 to 2.15), stability muscle area (1.68, 1.28 to 2.20), and stability muscle density (1.35, 1.03 to 1.76). After adjustment for relevant covariates, each SD increase in total moderate to vigorous PA was associated with a higher total abdominal ( β , 95% confidence interval = 0.068, 0.036 to 0.173), stability (0.063, 0.027 to 0.099), and locomotor (0.069, 0.039 to 0.099) muscle area and higher locomotor muscle density (0.065, 0.022 to 0.108, P   〈  .01). Only intentional and conditioning exercise were associated with total abdominal and stability muscle density ( P   〈  .05). Light PA and walking were not associated with muscle area or density. Conclusions: Most types of PA are positively associated with abdominal muscle area and density across functional categories, independent of relevant covariates. These results provide additional evidence for promoting PA for healthy muscle aging.
    Type of Medium: Online Resource
    ISSN: 1543-3080 , 1543-5474
    Language: Unknown
    Publisher: Human Kinetics
    Publication Date: 2022
    SSG: 31
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  • 6
    Online Resource
    Online Resource
    Korean Diabetes Association ; 2022
    In:  Diabetes & Metabolism Journal Vol. 46, No. 5 ( 2022-09-30), p. 747-755
    In: Diabetes & Metabolism Journal, Korean Diabetes Association, Vol. 46, No. 5 ( 2022-09-30), p. 747-755
    Abstract: Background: The weight-adjusted waist index (WWI) reflected body compositional changes with aging. This study was to investigate the association of WWI with abdominal fat and muscle mass in a diverse race/ethnic population.Methods: Computed tomography (CT) data from 1,946 participants for abdominal fat and muscle areas from the Multi-Ethnic Study of Atherosclerosis (785 Whites, 252 Asians, 406 African American, and 503 Hispanics) were used. Among them, 595 participants underwent repeated CT. The WWI was calculated as waist circumference (cm) divided by the square root of body weight (kg). The associations of WWI with abdominal fat and muscle measures were examined, and longitudinal changes in abdominal composition measures were compared.Results: In all race/ethnic groups, WWI was positively correlated with total abdominal fat area (TFA), subcutaneous fat area, and visceral fat area, but negatively correlated with total abdominal muscle area (TMA) and abdominal muscle radiodensity ( 〈 i 〉 P 〈 /i 〉 〈 0.001 for all). WWI showed a linear increase with aging regardless of race and there were no significant differences in the WWI distribution between Whites, Asians, and African Americans. In longitudinal analyses, over 38.6 months of follow-up, all abdominal fat measures increased but muscle measures decreased, along with increase in WWI. The more the WWI increased, the more the TFA increased and the more the TMA decreased.Conclusion: WWI showed positive associations with abdominal fat mass and negative associations with abdominal muscle mass, which likely reflects the abdominal compositional changes with aging in a multi-ethnic population.
    Type of Medium: Online Resource
    ISSN: 2233-6079 , 2233-6087
    Language: English
    Publisher: Korean Diabetes Association
    Publication Date: 2022
    detail.hit.zdb_id: 2602402-0
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  • 7
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2005
    In:  The Journal of Strength and Conditioning Research Vol. 19, No. 3 ( 2005), p. 534-
    In: The Journal of Strength and Conditioning Research, Ovid Technologies (Wolters Kluwer Health), Vol. 19, No. 3 ( 2005), p. 534-
    Type of Medium: Online Resource
    ISSN: 1064-8011 , 1533-4287
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2005
    detail.hit.zdb_id: 2142889-X
    SSG: 31
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2006
    In:  Respirology Vol. 11, No. 2 ( 2006-03), p. 175-181
    In: Respirology, Wiley, Vol. 11, No. 2 ( 2006-03), p. 175-181
    Abstract: Objective:  Evidence of significant oxygen requirements for ventilation during exercise (exercise hyperpnoea) prompted the investigation into whether the oxygen cost of ventilation affects the presence of a whole‐body VO 2 plateau at maximal exercise. The purposes of this study were to: (i) use isocapnic hyperpnoea trials to determine the oxygen cost of ventilation (VO 2VENT ) across a range of ventilation (V E ); (ii) determine the mean VO 2VENT at maximal exercise expressed as a percentage of whole‐body VO 2 max; and (iii) determine if a plateau in VO 2 is more evident when the VO 2VENT is subtracted from whole‐body VO 2 at maximal exercise. Methods:  A total of 21 subjects performed a VO 2 max test on the cycle ergometer to determine the range of V E for each subject. From the initial VO 2 max test, nine V E values across the range of V E were selected for each subject and the oxygen cost of each was measured. Results:  The mean maximal VO 2VENT equalled 8.8 ± 3.3% of VO 2 max and ranged from 5.0% to 17.6%. VO 2VENT increased exponentially with increasing V E , but there was considerable subject variability in the oxygen cost per litre of V E as V E increased. Subtracting the VO 2VENT from whole‐body VO 2 at maximal exercise increased the detection of a plateau in VO 2 at VO 2 max. Conclusions:  The data of the present study indicate that the VO 2VENT is a significant portion of VO 2 max and may be a limiting factor of maximal exercise performance in some subjects.
    Type of Medium: Online Resource
    ISSN: 1323-7799 , 1440-1843
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 2010720-1
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  • 9
    In: Obesity, Wiley, Vol. 26, No. 7 ( 2018-07), p. 1234-1241
    Abstract: This study examined the associations of muscle area and radiodensity with adiponectin and leptin. Methods A total of 1,944 participants who enrolled in the Multi‐Ethnic Study of Atherosclerosis underwent computed tomography to quantify body composition and measurements of adiponectin, leptin, interleukin‐6, C‐reactive protein, and resistin. Results The mean age and BMI of participants were 64.7 years and 28.1 kg/m 2 and 49% were female. With adjustment for age, gender, race/ethnicity, traditional cardiovascular disease risk factors, inflammatory biomarkers, physical activity, and sedentary behavior, a 1‐SD increment in total abdominal, stability, and locomotor muscle area was associated with a 19%, 17%, and 12% lower adiponectin level, respectively ( P   〈  0.01 for all) but not leptin ( P   〉  0.05). Muscle radiodensity was more robustly associated with adiponectin and leptin in the multivariable linear regression models. That is, with full adjustment for all covariates, a 1‐SD increment in total abdominal, stability, and locomotor muscle radiodensity was associated with a 31%, 31%, and 18% lower adiponectin level ( P   〈  0.01 for all) and a 6.7%, 4.6%, and 8.1% higher leptin level ( P   〈  0.05 for all), respectively. Conclusions The data suggest that increases in muscle area and radiodensity may have positive impacts on chronic inflammation and, in turn, reduce the risk of cardiometabolic disease.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2027211-X
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  • 10
    Online Resource
    Online Resource
    Wiley ; 2006
    In:  The FASEB Journal Vol. 20, No. 5 ( 2006-03)
    In: The FASEB Journal, Wiley, Vol. 20, No. 5 ( 2006-03)
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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