In:
Photochemistry and Photobiology, Wiley, Vol. 59, No. S1 ( 1994-05), p. 627-630
Abstract:
Abstract –We compared the photodynamic effects of thiopyronine (TP) and visible light, and 8‐methoxypsoralen (8‐MOP) and ultraviolet A (UV‐A) light, on growth, colony forming ability and RNA synthesis in a repair‐proficient Saccharomyces strain and three mutants deficient in DNA repair mechanisms (DNA repair assays). With 8‐MOP and UV‐A repair‐deficient mutants were significantly more sensitive than the repair‐proficient strain indicating that the system is sensitive for the detection of DNA damage. With TP and visible light, the photodynamic effects were comparable in the mutants and the control, indicating no DNA damage. These results support previous work showing that the main target of TP photosensitization in eukaryotes is not nuclear DNA.
Type of Medium:
Online Resource
ISSN:
0031-8655
,
1751-1097
DOI:
10.1111/php.1994.59.issue-S1
DOI:
10.1111/j.1751-1097.1994.tb08229.x
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
2048860-9
SSG:
12
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