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  • 1
    Online Resource
    Online Resource
    Gradual Drug Release Membranes and Films Used for the Treatment of Periodontal Disease
    MDPI AG ; 2022
    In:  Membranes Vol. 12, No. 9 ( 2022-09-17), p. 895-
    Details
    In: Membranes, MDPI AG, Vol. 12, No. 9 ( 2022-09-17), p. 895-
    Abstract: Periodontitis is an inflammatory disease that, if not treated, can cause a lot of harm to the oral cavity, to the patients’ quality of life, and to the entire community. There is no predictable standardized treatment for periodontitis, but there have been many attempts, using antibiotics, tissue regeneration techniques, dental scaling, or root planning. Due to the limits of the above-mentioned treatment, the future seems to be local drug delivery systems, which could gradually release antibiotics and tissue regeneration inducers at the same time. Local gradual release of antibiotics proved to be more efficient than systemic administration. In this review, we have made a literature search to identify the articles related to this topic and to find out which carriers have been tested for drug release as an adjuvant in the treatment of periodontitis. Considering the inclusion and exclusion criteria, 12 articles were chosen to be part of this review. The selected articles indicated that the drug-releasing carriers in periodontitis treatment were membranes and films fabricated from different types of materials and through various methods. Some of the drugs released by the films and membranes in the selected articles include doxycycline, tetracycline, metronidazole, levofloxacin, and minocycline, all used with good outcome regarding their bactericide effect; BMP-2, Zinc–hydroxyapatite nanoparticles with regenerative effect. The conclusion derived from the selected studies was that gradual drug release in the periodontal pockets is a promising strategy as an adjuvant for the treatment of periodontal disease.
    Type of Medium: Online Resource
    ISSN: 2077-0375
    URL: Article
    DOI: 10.3390/membranes12090895
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2614641-1
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  • 2
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    Online Resource
    Advanced Dentistry Biomaterials Containing Graphene Oxide
    MDPI AG ; 2024
    In:  Polymers Vol. 16, No. 12 ( 2024-06-19), p. 1743-
    Details
    In: Polymers, MDPI AG, Vol. 16, No. 12 ( 2024-06-19), p. 1743-
    Abstract: The aim of this study was to obtain three experimental resin-based cements containing GO and HA-Ag for posterior restorations. The samples (S0, S1, and S2) shared the same polymer matrix (BisGMA, TEGDMA) and powder mixture (bioglass (La2O3 and Sr-Zr), quartz, GO, and HA-Ag), with different percentages of graphene oxide (0%, 0.1%, 0.2% GO) and silver-doped hydroxyapatite (10%, 9.9%, 9.8% HA-Ag). The physical–chemical properties (water absorption, degree of conversion), mechanical properties (DTS, CS, FS), structural properties (SEM, AFM), and antibacterial properties (Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans, Porphyromonas gingivalis, and Escherichia coli) were investigated. The results showed that the mechanical properties, except for the diametral tensile test, increased with the rise in the %GO. After 28 days, water absorption increased with the rise in the %GO. The surface structure of the samples did not show major changes after water absorption for 28 days. The antibacterial effects varied depending on the samples and bacterial strains tested. After increasing the %GO and decreasing the %HA-Ag, we observed a more pronounced antibacterial effect. The presence of GO, even in very small percentages, improved the properties of the tested experimental cements.
    Type of Medium: Online Resource
    ISSN: 2073-4360
    URL: Article
    DOI: 10.3390/polym16121743
    Language: English
    Publisher: MDPI AG
    Publication Date: 2024
    detail.hit.zdb_id: 2527146-5
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  • 3
    Online Resource
    Online Resource
    Synthesis and characterization of graphene oxide-zirconia (GO-ZrO2) and hydroxyapatite-zirconia (HA-ZrO2) nano-fillers for resin-based composites for load-bearing applications
    Elsevier BV ; 2021
    In:  Journal of Dentistry Vol. 105 ( 2021-02), p. 103557-
    Details
    In: Journal of Dentistry, Elsevier BV, Vol. 105 ( 2021-02), p. 103557-
    Type of Medium: Online Resource
    ISSN: 0300-5712
    URL: Article
    DOI: 10.1016/j.jdent.2020.103557
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2006760-4
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  • 4
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    Antimicrobial Poly (Lactic Acid)/Copper Nanocomposites for Food Packaging Materials
    MDPI AG ; 2023
    In:  Materials Vol. 16, No. 4 ( 2023-02-08), p. 1415-
    Details
    In: Materials, MDPI AG, Vol. 16, No. 4 ( 2023-02-08), p. 1415-
    Abstract: Composites based on polylactic acid (PLA) and copper for food packaging applications were obtained. Copper clusters were synthesized in polyethylene glycols 400 and 600, respectively, using ascorbic acid as a reducing agent, by reactive milling. Copper clusters were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FT-IR), and Ultraviolet-Visible (UV-VIS) spectroscopy. Copper/PLA composites containing Proviplast as plasticizer were characterized by FT-IR spectroscopy, mechanical tests, Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), absorption of the saline solution, contact angle, and antibacterial properties. It was observed that the concentration of Copper/PEG influenced the investigated properties. The mechanical properties of the samples decreased with the increasing of Copper/PEG concentration. We recorded the phase transformation temperatures and identified the exothermic or endothermic processes. The lowest absorption values were recorded in the case of the sample containing 1% Cu. The contact angle decreases with the increase in the concentration of the PEG 600-Cu mixture in the recipes. The increase in the content of Cu clusters favors the decrease in the temperature, taking place 15% wt mass losses. The obtained composites showed antibacterial properties for all tested strains. These materials could be used as alternative materials for obtaining biodegradable food packaging.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma16041415
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2487261-1
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  • 5
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    Online Resource
    Dental Sealant Composition-Retention Assessment in Young Permanent Molars
    MDPI AG ; 2021
    In:  Materials Vol. 14, No. 7 ( 2021-03-27), p. 1646-
    Details
    In: Materials, MDPI AG, Vol. 14, No. 7 ( 2021-03-27), p. 1646-
    Abstract: Tooth decay in children and adolescents remains a public health problem, despite prophylaxis and preventive measures being largely available. The aim of our study was to evaluate the clinical behavior of four dental sealants, related to first permanent molar topography and patient age (when sealant was applied for the first time). We assessed, by means of visual inspection and palpation with a dental probe, a group of 200 children, enrolled corresponding to school age-grade (mean age of 7 years at baseline) and randomly divided according to the material used as dental sealant (Admira seal©, Embrace Wet Bond©, Fotoseal©, GC Fuji Triaje©) in 4 groups (n = 50). Sealant clinical evaluation was made at 6-, 12-, 18-month intervals for dental material retention assessment. At 6 months, the sealant detached the most from 3.6 molars, and the material used was Fotoseal© (27.6%). At 12 months, Fotoseal© (48.3%) and GC Fuji Triaje© (41.4%) from 3.6 molars express detachment. At 18 months, 4.6. molars sealed with Admira Seal© (25.7%) and Embrace Wet Bond© (28.6%) lost the sealant. We noticed less detachment in maxillary molars and if sealant was applied around 7 years of age. In conclusion, sealant application on first permanent molars must be encouraged and practitioners can choose between various materials available.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma14071646
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2487261-1
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  • 6
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    Online Resource
    Preparation and Characterization of Natural Bleaching Gels Used in Cosmetic Dentistry
    MDPI AG ; 2019
    In:  Materials Vol. 12, No. 13 ( 2019-06-30), p. 2106-
    Details
    In: Materials, MDPI AG, Vol. 12, No. 13 ( 2019-06-30), p. 2106-
    Abstract: The novelty of this study consists of the formulation and characterization of three experimental bleaching gels with hydroxylapatite oxides and fluorine (G28®, G29®, G30®) based on natural fruit extracts compared to the commercial Opalescence 15% (GC, Ultradent, South Jordan, UT, USA). Studies have been conducted on the effect that the experimental bleaching gels have on the color and morphology of different restorative materials (Nanofill®-Schulzer, P.L. Superior Dental Materials GmbH, Hamburg, Germany, and experimental nanocomposites (P11®, P31®, P61®)), immersed in coffee and artificial saliva (for 10 days and 30 days). The study also includes a cytotoxicity test on the gels and nanocomposites after bleaching, with ISO 109993-5 protocols on human dental follicle stem cells. UV-VIS spectroscopy, computerized measurement, and fluorescence spectrometry were used in order to observe the color changes, while the microstructure of the surface was investigated by Scanning Electron Microscopy (SEM). All of the samples immersed in coffee showed the highest color shift in comparison to the baseline. The color difference ΔE values obtained using the two methods (UV-Vis, computerized based on digital images) both after coloring and bleaching, respectively, were different for all four types of nanocomposites stored in the coffee, while no difference was observed in those stored in artificial saliva. The studied experimental gels and nanocomposites had a low cytotoxic effect on cell cultures after bleaching.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma12132106
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2487261-1
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  • 7
    Online Resource
    Online Resource
    In Vitro Study of Composite Cements on Mesenchymal Stem Cells of Palatal Origin
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 13 ( 2023-06-30), p. 10911-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 13 ( 2023-06-30), p. 10911-
    Abstract: Uniform filler distribution in composites is an important requirement. Therefore, BaO glass, nano hydroxyapatite and quartz filler distribution was realized through PCL microcapsules which progressively release filler during matrix polymerization. Two composites were realized based on a complex matrix containing BisGMA, UDMA, HEMA and PEG400 mixed with a previously described mineral filler: 33% for C1 and 31% for C2. The spreading efficiency was observed via SEM, revealing a complete disintegration of the microcapsules during C1 polymerization, while C2 preserved some microcapsule parts that were well embedded into the matrix beside BaO filler particles; this was confirmed by means of the EDS spectra. Mesenchymal stem cells of palatal origin were cultured on the composites for 1, 3, 5 and 7 days. The alkaline phosphatase (ALP) level was measured at each time interval and the cytotoxicity was tested after 3, 5 and 7 days of co-culture on the composite samples. The SEM investigation showed that both composites allowed for robust proliferation of the cells. The MSC cell pluripotency stage was observed from 1 to 3 days with an average level of ALP of 209.2 u/L for C1 and 193.0 u/L for C2 as well as a spindle cell morphology. Cell differentiation occurred after 5 and 7 days of culture, implied by morphological changes such as flattened, star and rounded shapes, observed via SEM, which were correlated with an increased ALP level (279.4 u/L for C1 and 284.3 u/L for C2). The EDX spectra after 7 days of co-culture revealed increasing amounts of P and Ca close to the hydroxyapatite stoichiometry, indicating the stimulation of the osteoinductive behavior of MSCs by C1 and C2. The MTT assay test showed a cell viability of 98.08% for C1 and 97.33% for C2 after 3 days, proving the increased biocompatibility of the composite samples. The cell viability slightly decreased at 5 and 7 days but the results were still excellent: 89.5% for C1 and 87.3% for C2. Thus, both C1 and C2 are suitable for further in vivo testing.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms241310911
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 8
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    Marginal Adaptation Assessment for Two Composite Layering Techniques Using Dye Penetration, AFM, SEM and FTIR: An In-Vitro Comparative Study
    MDPI AG ; 2021
    In:  Applied Sciences Vol. 11, No. 12 ( 2021-06-18), p. 5657-
    Details
    In: Applied Sciences, MDPI AG, Vol. 11, No. 12 ( 2021-06-18), p. 5657-
    Abstract: Do the new, modern dental resin composites improve the sealing in cavities restorations? The present study was designed to compare the effect of two different, but most used layering techniques of the dental composite in reducing the marginal microleakage when a brand-new material is used; Class I black cavities were prepared on 120 human extracted teeth and then restored using oblique and horizontal layering technique. The dye penetration analysis, the atomic force microscopy (AFM), scanning electron microscopy (SEM) together with energy-dispersive X-ray spectroscopy (EDX) and Fourier transform infra-red spectroscopy (FTIR) technique were used to assess the adaptation of the restorative material to the dental structures. Some better results were obtained for oblique layering technique, but the differences to the other method have not been statistically validated. The composite layering technique still remains an open quest and, moreover, in vivo studies should be designed in order to assess microleakage in real conditions of the oral environment.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app11125657
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2704225-X
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  • 9
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    Online Resource
    Hydrolytic Degradation of Dental Composites
    Trans Tech Publications, Ltd. ; 2014
    In:  Key Engineering Materials Vol. 614 ( 2014-6), p. 113-117
    Details
    In: Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 614 ( 2014-6), p. 113-117
    Abstract: This study evaluated the hydrolytic degradation of two experimental (C1, C2) and two commercial composite (Tetric EvoCeram and Premise) prepared to be used in dental restorations. Two experimental composites and two commercial composites were undergoing hydrolytic degradation in three different medium: distilled water, artificial saliva and alcoholic solution (50/50). The samples were investigated immediately after polymerisation with halogen lamp Optilux 501 and after 33 days of immersion in all three medium, using Fourier transforms infrared analysis (FTIR). FT-IR spectra of samples from the same composite immersed in distilled water, artificial saliva and alcoholic solution, revealed mostly reducing the intensity of the characteristic peaks of Si-O-Si bond less Tetric composite immersed in artificial saliva, which peak intensity remains unchanged.
    Type of Medium: Online Resource
    ISSN: 1662-9795
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/KEM.614
    DOI: 10.4028/www.scientific.net/KEM.614.113
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2014
    detail.hit.zdb_id: 2073306-9
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  • 10
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    Online Resource
    The Side Effects of Therapeutic Radioiodine-131 on the Structure of Enamel and Dentin in Permanent Human Teeth
    MDPI AG ; 2021
    In:  Biology Vol. 10, No. 4 ( 2021-04-01), p. 284-
    Details
    In: Biology, MDPI AG, Vol. 10, No. 4 ( 2021-04-01), p. 284-
    Abstract: Radioiodine-131 (I-131) is an essential therapy for patients with differentiated thyroid carcinomas (DTC). Generally, I-131 is safe and well tolerated, but patients may present early or late complications in the oral and maxillofacial areas. Thus, the aim of this study was to evaluate in-vitro, the alteration of enamel and dentin after I-131 exposure using histopathological assessment, scanning electron microscopy (SEM) and atomic force microscopy (AFM). For I-131 irradiation, an in-vitro protocol was used that simulates the procedure for irradiation therapy performed for patients with DTCs. A total of 42 teeth were divided into seven groups (n = 6) and irradiated as follows: control, irradiation groups (3, 6, 12, 36, 48 h, 8 days). Histological changes were observed at 48 h (enamel surface with multifocal and irregular areas) and at 8 days (enamel surface with multiple, very deep, delimited cavities). SEM imaging revealed the enamel destruction progresses along with the treatment time increasing. The alterations are extended into the enamel depth and the dislocated hydroxyapatite debris is overwhelming. The enamel-dentine interface shows small gaps after 6 h and a very well developed valley after 12 h; the interface microstructure resulted after 8 days is deeply altered. The AFM imaging shows that I-131 affects the protein bond between hydroxyapatite nano-crystals causing loss of cohesion, which leads to significant increasing of nano-particles diameter after 6 h. In conclusion, both enamel and dentin appear to be altered between 12 and 48 h and after 8 days of treatment are extended in depth.
    Type of Medium: Online Resource
    ISSN: 2079-7737
    URL: Article
    DOI: 10.3390/biology10040284
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2661517-4
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