In:
Journal of Separation Science, Wiley, Vol. 35, No. 17 ( 2012-09), p. 2273-2281
Abstract:
Resolution of racemic mandelic acid (( R , S )‐ MA ) and numerical determination of binary competitive isotherm of ( R , S )‐ MA on C hiralcel‐ OD column have been investigated in this study. The effects of the alcohol modifier and acidic additive in the mobile phase on the retention and enantioseparation of ( R , S )‐ MA were studied at first. The inverse method was then used to determine the competitive isotherm parameters of ( R , S )‐ MA by minimizing the sum of square deviations of the model predictions from the measured elution profiles. The results indicate that the mobile phase with 85% hexane/15% isopropanol/0.3% trifluoroacetic acid mixture gives the best resolution of ( R , S )‐ MA and competitive‐modified L angmuir isotherm provides the more accurate sorption mechanism of ( R , S )‐ MA on the cellulose tris(3,5‐dimethylphenylcarbamate) chiral stationary phase.
Type of Medium:
Online Resource
ISSN:
1615-9306
,
1615-9314
DOI:
10.1002/jssc.201200322
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2047990-6
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