In:
Alzheimer's & Dementia, Wiley, Vol. 16, No. S10 ( 2020-12)
Abstract:
Addenbrooke’s Cognitive Examination (ACE‐III) is a well‐validated cognitive screening test, designed to detect Dementia. This work intends to investigate the influence of age, gender, and education in Indian population. Method Srinivaspura Aging, Neuro Senescence and COGnition (SANSCOG) study and Tata Longitudinal Study on Aging (TLSA) are parallel, prospective, community‐based, cohort studies in India – rural and urban respectively – for comprehensive evaluation of risk and protective factors associated with cognitive changes due to normal ageing, Alzheimer’s disease and other related disorders. 444 and 1344 volunteers were enrolled in TLSA and SANSCOG respectively. ACE‐III was administered on them by trained psychologists. They were classified in four age groups (45– 55, 56–65, 66‐75, and 〉 75 years of age) and six levels for years of education (0‐4, 5‐8, 9‐12, 13‐15, 16‐18, 〉 18). Univariate analysis was performed to study the effect of age, gender, or education, on the ACE‐III total scores. Multivariate analysis was done to study the effects of age, gender, and education on the different cognitive domains of ACE‐III. Result No significant differences were observed for ACE‐III among different age groups or gender for individuals enrolled in TLSA, as well as those in SANSCOG. The level of education had a significant effect on ACE‐III as well as all the sub‐domains for SANSCOG participants, but not for TLSA participants. However, age or gender do not show such trends. When the effect of age, gender, and level of education was jointly assessed on these indices, they were found to have significant effects only for visuospatial domain for TLSA participants; and attention and visuospatial domain for SANSCOG participants. Additionally, memory, fluency, language, visuospatial indices of ACE‐III are significantly affected by the age of the participant in SANSCOG. Conclusion These results show that age, gender and education of participants can have important effects on performance of ACE‐III and its cognitive sub‐domains. Nevertheless, this is an ongoing work, and currently more participants are being assessed in both the studies who would be followed up longitudinally, which can yield precise conclusive results in future.
Type of Medium:
Online Resource
ISSN:
1552-5260
,
1552-5279
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2201940-6
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