In:
Perfusion, SAGE Publications, Vol. 15, No. 3 ( 2000-05), p. 211-216
Kurzfassung:
Contact with the synthetic surfaces of an extracorporeal circuit induces alterations in vascular components, derangements of the coagulation cascade and a systemic inflammatory response. Aprotinin reduces intraoperative and postoperative bleeding in adults undergoing cardiopulmonary bypass; however, trials in children have not had similar favorable results. While there have been some anecdotal reports, there have been no prospective clinical trials exploring the utility of aprotinin in the prevention of or as a therapy for bleeding while on extracorporeal life support (ECLS). We present a case series on our experience utilizing aprotinin for the treatment of life-threatening bleeding during ECLS. The combination of a loading dose followed by a continuous infusion resulted in significant reduction in blood loss and blood product utilization. This suggests that aprotinin may have clinical efficacy in the management of massive blood loss while on ECLS; however, larger controlled trials will be essential to determine the efficacy and appropriate dosing regimens before widespread use in ECLS can be advocated.
Materialart:
Online-Ressource
ISSN:
0267-6591
,
1477-111X
DOI:
10.1177/026765910001500305
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2000
ZDB Id:
2029611-3
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