In:
ChemMedChem, Wiley, Vol. 8, No. 4 ( 2013-04), p. 652-657
Abstract:
The NorA efflux pump lowers intracellular fluoroquinolone concentrations by expelling antibiotics through the membrane of Staphylococcus aureus . We identified 3‐aryl‐4‐methyl‐2‐quinolin‐2‐ones as compounds able to restore the activity of the NorA substrate, ciprofloxacin, against resistant S. aureus strains, and acting as efflux pump inhibitors (EPI). In particular, 5‐hydroxy‐7‐methoxy‐4‐methyl‐3‐phenylquinolin‐2‐one ( 6 c ) presents both an EPI and an antimicrobial effect. Its efficacy and safety make it a potential candidate for further investigations.
Type of Medium:
Online Resource
ISSN:
1860-7179
,
1860-7187
DOI:
10.1002/cmdc.201200551
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2209649-8
SSG:
15,3
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