In:
FEBS Letters, Wiley, Vol. 462, No. 3 ( 1999-12-03), p. 322-328
Abstract:
Several malignant cell lines are resistant to CD95(Apo1/Fas)‐mediated apoptosis, even when the CD95 receptor is highly expressed. Sensitivity to CD95‐induced apoptosis can be restored using different molecules. In this study, we showed that quercetin, a naturally occurring flavonoid, in association with the agonistic anti‐CD95 monoclonal antibody, increases DNA fragmentation and caspase‐3 activity in HPB‐ALL cells. These cells have been selected for their known resistance to CD95‐induced apoptosis. At molecular level, quercetin lowers the level of intracellular reactive oxygen species, reduces mitochondrial transmembrane potential, thereby leaving the expression of CD95 receptor unchanged.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(99)01544-6
Language:
English
Publisher:
Wiley
Publication Date:
1999
detail.hit.zdb_id:
1460391-3
SSG:
12
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