In:
Angewandte Chemie, Wiley, Vol. 134, No. 20 ( 2022-05-09)
Abstract:
A new class of chiral 2,2′‐bipyridine ligands, SBpy, featuring minimized short‐range steric hindrance and structural tunability was rationally designed and developed, and the effectiveness was demonstrated in the first highly enantioselective Ni‐catalyzed addition of aryl halides to aldehydes. In comparison with known approaches using preformed aryl metallic reagents, this reaction is more step‐economical and functional group tolerant. The reaction mechanism and a model of stereocontrol were proposed based on experimental and computational results.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v134.20
DOI:
10.1002/ange.202117843
Language:
English
Publisher:
Wiley
Publication Date:
2022
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505872-7
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1479266-7
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