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  • Online Resource  (9)
  • Wiley  (9)
  • 1
    Online Resource
    Online Resource
    Wiley ; 2021
    In:  Clinical Cardiology Vol. 44, No. 3 ( 2021-03), p. 364-370
    In: Clinical Cardiology, Wiley, Vol. 44, No. 3 ( 2021-03), p. 364-370
    Abstract: The significance of left atrial volume index (LAVI) for predicting outcomes in patients with mitral stenosis (MS) has been unclear, even though rheumatic MS is known to be associated with left atrium enlargement and functional deterioration. Hypothesis The current study aimed to investigate the prognostic value of LAVI, based on the severity in patients with rheumatic MS. Methods We retrospectively reviewed 611 patients with pure rheumatic MS. The prognostic value of LAVI and the effect of MS severity on the prognostic value of LAVI for events were evaluated. The events were defined as a composite end‐point that included all‐cause death, heart failure admission, mitral valve replacement, percutaneous mitral valvuloplasty, and stroke. Results There were 236 (38.6%) overall events during a median follow‐up of 8 months. The optimal LAVI cutoff for the prognostic threshold was 57 ml/m 2 . The MS severity had a significant effect on the prognostic value of LAVI. A LAVI 〉 57 ml/m 2 was a prognostic value for events in progressive MS (hazard ratio [HR]: 2.40, 95% confidence interval [CI] : 1.41–5.40, p = .004) and in patients with severe MS (HR: 1.70, 95% CI: 1.06–2.74, p = .029), but it was not prognostic in patients with very severe MS (HR: 1.02, 95% CI: 0.56–1.84, p = .955). Conclusions The prognostic value of LAVI varies and is dependent on the MS severity. A LAVI 〉 57 mL/m 2 was independently associated with poor outcomes in patients with progressive MS, while this association was minimized in patients with severe MS.
    Type of Medium: Online Resource
    ISSN: 0160-9289 , 1932-8737
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2048223-1
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  • 2
    Online Resource
    Online Resource
    Wiley ; 2018
    In:  ETRI Journal Vol. 40, No. 1 ( 2018-02), p. 146-155
    In: ETRI Journal, Wiley, Vol. 40, No. 1 ( 2018-02), p. 146-155
    Type of Medium: Online Resource
    ISSN: 1225-6463
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2119239-X
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  • 3
    Online Resource
    Online Resource
    Wiley ; 2020
    In:  Echocardiography Vol. 37, No. 8 ( 2020-08), p. 1164-1170
    In: Echocardiography, Wiley, Vol. 37, No. 8 ( 2020-08), p. 1164-1170
    Abstract: Although significant stenosis and regurgitation can be observed on a single heart valve, studies on the outcome predictors for mixed valve disease are limited. The purpose of the current study was to investigate the fate and determinants of clinical outcomes in patients with mixed single mitral valve disease who have concomitant mitral stenosis (MS) and mitral regurgitation (MR). Methods We retrospectively reviewed 82 consecutive patients with rheumatic heart disease who had both significant MS (MVA ≤ 1.5 cm 2 ) and at least moderate MR, excluding patients with significant aortic valve stenosis or regurgitation. The primary endpoint was a composite of all‐cause mortality during follow‐up, mitral valve replacement, heart failure admission, and stroke. Results There were 37 events (45.1%), 5 all‐cause deaths (6.0%), and 32 mitral valve replacements (39.0%). In a multivariable Cox regression analysis, a transmitral mean pressure gradient (TMPG) over 6 mm Hg was the only independent echocardiographic predictor for events (hazard ratio 3.69, 95% confidential interval 1.31–10.44, P  = .014), after adjusting for sex, age, symptoms, and the severity of MS and MR. The estimated 6‐year event‐free survival rate was significantly lower in patients with TMPG ≥ 6 mm Hg than in those with TMPG  〈  6 mm Hg (76.3% vs 22.9%, log‐rank P   〈  .001). Conclusion Transmitral mean pressure gradient, which reflects the hemodynamic burden of the mitral valve lesion, appears to be the most important echocardiographic predictor of clinical outcomes in patients with mixed mitral valve disease.
    Type of Medium: Online Resource
    ISSN: 0742-2822 , 1540-8175
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2041033-5
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  • 4
    Online Resource
    Online Resource
    Wiley ; 2016
    In:  Hemodialysis International Vol. 20, No. 1 ( 2016-01), p. 129-133
    In: Hemodialysis International, Wiley, Vol. 20, No. 1 ( 2016-01), p. 129-133
    Abstract: Fluid shifts are common in patients undergoing chronic hemodialysis ( HD ) during the intradialytic periods, as several liters of fluid are removed during ultrafiltration ( UF ). Some patients have experienced frequent intradialytic hypotension ( IDH ). However, the characteristics of fluid shifts and which fluid space is affected remain controversial. Therefore, we designed this study to evaluate the fluid spaces most affected by UF and to determine whether hydration status influences the fluid shifts during HD . This was a prospective cohort study of 40 patients undergoing HD . We measured the patient's fluid spaces using a whole‐body bioimpedance apparatus to evaluate the changes in the fluid spaces before HD and 1–4 hours of HD and 30 minutes after HD . UF achieved during HD by the 40 patients (age, 60.0 ± 5.2 years; 50% men; 50% of patients with diabetes; body weight, 61.3 ± 10.5 kg) was 2.18 ± 0.78 L (measured fluid overload, 2.15 ± 1.24 L). 1) Mean relative reduction of total body water and extracellular water was reduced from the start to the end of HD. 2) However, mean relative reduction of intracellular water was not reduced from the start to the end of HD. 3) No significant differences in fluid shifts were observed according to hydration status. The source of net UF during HD is mostly the extracellular space regardless of hydration status. Thus, IDH may be related to differences in the interstitial fluid shift to the vascular space.
    Type of Medium: Online Resource
    ISSN: 1492-7535 , 1542-4758
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2103570-2
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  • 5
    In: Angewandte Chemie, Wiley, Vol. 130, No. 26 ( 2018-06-25), p. 7890-7894
    Abstract: Naphthalene oxidation with metal–oxygen intermediates is a difficult reaction in environmental and biological chemistry. Herein, we report that a Mn IV bis(hydroxo) complex, which was fully characterized by various physicochemical methods, such as ESI‐MS, UV/Vis, and EPR analysis, X‐ray diffraction, and XAS, can be employed for the oxidation of naphthalene in the presence of acid to afford 1,4‐naphthoquinone. Redox titration of the Mn IV bis(hydroxo) complex gave a one‐electron reduction potential of 1.09 V, which is the most positive potential for all reported nonheme Mn IV bis(hydroxo) species as well as Mn IV oxo analogues. Kinetic studies, including kinetic isotope effect analysis, suggest that the naphthalene oxidation occurs through a rate‐determining electron transfer process.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    RVK:
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2018
    In:  Angewandte Chemie International Edition Vol. 57, No. 26 ( 2018-06-25), p. 7764-7768
    In: Angewandte Chemie International Edition, Wiley, Vol. 57, No. 26 ( 2018-06-25), p. 7764-7768
    Abstract: Naphthalene oxidation with metal–oxygen intermediates is a difficult reaction in environmental and biological chemistry. Herein, we report that a Mn IV bis(hydroxo) complex, which was fully characterized by various physicochemical methods, such as ESI‐MS, UV/Vis, and EPR analysis, X‐ray diffraction, and XAS, can be employed for the oxidation of naphthalene in the presence of acid to afford 1,4‐naphthoquinone. Redox titration of the Mn IV bis(hydroxo) complex gave a one‐electron reduction potential of 1.09 V, which is the most positive potential for all reported nonheme Mn IV bis(hydroxo) species as well as Mn IV oxo analogues. Kinetic studies, including kinetic isotope effect analysis, suggest that the naphthalene oxidation occurs through a rate‐determining electron transfer process.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 7
    Online Resource
    Online Resource
    Wiley ; 2019
    In:  International Wound Journal Vol. 16, No. S1 ( 2019-03), p. 71-75
    In: International Wound Journal, Wiley, Vol. 16, No. S1 ( 2019-03), p. 71-75
    Abstract: A research survey research was conducted to identify factors affecting changes in bowel habits of rectal cancer patients undergoing sphincter‐saving surgery and to provide basic information useful in nursing interventions supporting treatment for rectal cancer patients. The subjects were rectal cancer patients who had undergone sphincter‐saving surgery over 2 years ago. The final analysis included 107 patients who had made outpatient visits to the colorectal surgery from 12th to 31st May, 2014. Collected data were processed with SPSS Version 21.0. Changes in bowel habits in the subjects were observed: frequent bowel movement in 74 patients (69.2%) and faecal incontinence in 48 (44.9%). Most of the patients used self‐care to improve their bowel function including dietary modification (78.5%), regular exercise (72.0%) and pelvic floor exercise (34.6%). Frequent defecation was associated with adjuvant chemoradiation therapy ( P 〈  0.001) and faecal incontinence was associated with age of ≥65 years ( P = 0.019) and a group who underwent adjuvant radiation therapy ( P 〈  0.001). It is necessary to give sufficient information about possible postoperative changes in bowel habits to patients with the risk factors before surgery.
    Type of Medium: Online Resource
    ISSN: 1742-4801 , 1742-481X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2152163-3
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2022
    In:  Protein Science Vol. 31, No. 5 ( 2022-05)
    In: Protein Science, Wiley, Vol. 31, No. 5 ( 2022-05)
    Abstract: PDB Code(s): 7WM5 and 7WM6 ;
    Type of Medium: Online Resource
    ISSN: 0961-8368 , 1469-896X
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2000025-X
    SSG: 12
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  • 9
    In: ESC Heart Failure, Wiley, Vol. 7, No. 5 ( 2020-10), p. 2933-2940
    Abstract: Arrhythmogenic cardiomyopathy (AC) is characterized by right ventricular (RV) dilatation and dysfunction and is often seen in combination with tricuspid regurgitation (TR). The aim of this study was to investigate the characteristics and prognostic implications of TR in patients with AC. Methods and results Clinical, echocardiographic, and cardiac magnetic resonance data of 52 patients with AC fulfilling 2010 Task Force criteria in a single centre were retrospectively evaluated. TR in AC was classified as no/mild, moderate, or severe on the basis of the current guidelines. Significant TR was defined as at least moderate TR. The primary endpoint was a composite of death, heart transplantation, and tricuspid valve surgery. There were seven patients (13.4%) with moderate TR and 13 patients (25.0%) with severe TR at initial diagnosis. Patients with severe TR showed a higher prevalence of atrial fibrillation and a higher mean NT‐pro‐BNP than other groups (68%, P  = 0.013; 2423 ± 1578 pg/mL, P   〈  0.001, respectively). Patients with significant TR revealed a higher incidence of heart failure at initial presentation than did those without significant TR (30.0 vs. 3.1%, P  = 0.022). Patients with severe TR showed significantly larger RV and lower RV and left ventricular functional parameters. During a mean follow‐up of 4.2 years, three groups classified by TR severity considerably discriminated clinical outcomes (log rank P  = 0.019). Patients with significant TR had a poorer prognosis than those with no or mild TR (42.9 vs. 3.1%, log rank P  = 0.005). Cox regression analysis showed significant TR as an independent prognostic factor (hazard ratio 11.41, 95% confidential interval 1.30–99.92, P  = 0.028). Conclusions Significant TR at initial diagnosis in patients with AC is a poor prognostic factor.
    Type of Medium: Online Resource
    ISSN: 2055-5822 , 2055-5822
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2814355-3
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