GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Online Resource  (16)
  • Wiley  (16)
  • 1
    Online Resource
    Online Resource
    Anticancer, antithrombotic, antityrosinase, and anti‐α‐glucosidase activities of selected wild and commercial mushrooms from Pakistan
    Wiley ; 2018
    In:  Food Science & Nutrition Vol. 6, No. 8 ( 2018-11), p. 2170-2176
    Details
    In: Food Science & Nutrition, Wiley, Vol. 6, No. 8 ( 2018-11), p. 2170-2176
    Abstract: Mushrooms have been accepted as nutraceutical foods because of their high nutritional and functional values. They have also gained interest due to their medicinal properties, economic importance, and organoleptic merit. In this study, wild Ganoderma lucidum and four commercial mushrooms, that is, Pleurotus ostreatus, Volvariella volvacea, Hericium erinaceus, and Lentinus edodes from Pakistan were screened for their biological activities such as anticancer, antityrosinase, anti‐α‐glucosidase, and antithrombotic activities from their methanol, ethanol, and water extracts. Enzyme inhibition assay showed that selected mushrooms are potent inhibitors with %age inhibition ranging from 19.00% to 80.91%, and 32.85% to 83.38% for tyrosinase and α‐glucosidase, respectively. The best tyrosinase inhibition was shown by P. ostreatus whereas L. edodes was found best as α‐glucosidase inhibitor. These mushrooms were tested against cancer cell lines including HT ‐29 colon and H‐1299 lungs carcinoma cell lines. G. lucidum showed 29% and 24% viability of cells against HT ‐29 and H‐1299 cell lines, respectively. This antiproliferative effect was in dose‐dependent manner, and the maximum inhibition was observed at 200 μg/ ml . Mushrooms extracts were also found effective against clot lysis. The percentage of clot lysis was in the range of 27%–29%. The research would provide knowledge to the people of Pakistan about the importance of locally available commercial mushrooms and wild mushrooms for health improvement and prevention against different kinds of diseases.
    Type of Medium: Online Resource
    ISSN: 2048-7177 , 2048-7177
    URL: Issue
    URL: Article
    DOI: 10.1002/fsn3.2018.6.issue-8
    DOI: 10.1002/fsn3.781
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2703010-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Bisphenol A Induces Histopathological, Hematobiochemical Alterations, Oxidative Stress, and Genotoxicity in Common Carp (Cyprinus carpio L.)
    Wiley ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-1-28), p. 1-14
    Details
    In: Oxidative Medicine and Cellular Longevity, Wiley, Vol. 2022 ( 2022-1-28), p. 1-14
    Abstract: Bisphenol A (BPA) is one of the environmental endocrine disrupting toxicants and is widely used in the industry involving plastics, polycarbonate, and epoxy resins. This study was designed to investigate the toxicological effects of BPA on hematology, serum biochemistry, and histopathology of different organs of common carp (Cyprinus carpio). A total of 60 fish were procured and haphazardly divided into four groups. Each experimental group contained 15 fish. The fish retained in group A was kept as the untreated control group. Three levels of BPA 3.0, 4.5, and 6 mg/L were given to groups B, C, and D for 30 days. Result indicated significant reduction in hemoglobin (Hb), lymphocytes, packed cell volume (PCV), red blood cells (RBC), and monocytes in a dose-dependent manner as compared to the control group. However, significantly higher values of leucocytes and neutrophils were observed in the treated groups ( P 〈 0.05 ). Results on serum biochemistry revealed that the quantity of glucose, cholesterol, triglycerides, urea, and creatinine levels was significantly high ( P 〈 0.05 ). Our study results showed significantly ( P 〈 0.05 ) increase level of oxidative stress parameters like reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS) and lower values of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) in treated groups (4.5 mg/L and 6 mg/L)) in the brain, liver, gills, and kidneys. Our study depicted significant changes in erythrocytes (pear shaped erythrocytes, leptocytes, microcytes, spherocytes, erythrocytes with broken, lobed, micronucleus, blabbed, vacuolated nucleus, and nuclear remnants) among treated groups (4.5 mg/L and 6 mg/L). Comet assay showed increased genotoxicity in different tissues including the brain, liver, gills, and kidneys in the treated fish group. Based on the results of our experiment, it can be concluded that the BPA exposure to aquatic environment is responsible for deterioration of fish health, performance leading to dysfunction of multiple vital organs.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/5450421
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Positive Selection in Zinc Finger Protein Reveals Genetic Signatures of Adaptive Evolution in Undifferentiated Stem Cells during Evolution in Mammals
    Wiley ; 2023
    In:  Journal of Zoological Systematics and Evolutionary Research Vol. 2023 ( 2023-5-29), p. 1-15
    Details
    In: Journal of Zoological Systematics and Evolutionary Research, Wiley, Vol. 2023 ( 2023-5-29), p. 1-15
    Abstract: Positive selection refers to the process by which certain genetic variations are more likely to be passed on to future generations because they confer some advantage in terms of survival or reproduction. Zinc finger proteins are a type of transcription factor that plays a role in regulating gene expression, particularly in undifferentiated stem cells. Suppose it has been found that certain zinc finger proteins show genetic signatures of positive selection in mammals. In that case, it suggests that these proteins may have played a role in adaptive evolution in undifferentiated stem cells. This could mean that the specific genetic changes in these zinc finger proteins gave an advantage to the organisms that possessed them, helping them survive and reproduce more effectively. These genetic changes may have allowed the organisms to adapt to changing environments or to develop new abilities, such as increased resistance to disease or faster growth. Undifferentiated stem cells that underwent adaptive evolution during the evolution of mammals can be identified genetically by the outcomes of positive selection on zinc finger proteins. Because of selection pressures like environmental shifts or the introduction of novel pathogens, it is plausible that some zinc finger proteins have experienced fast evolution. The emergence of novel activities or higher expression levels of these proteins as a result of this quick evolution may have given the creatures that possessed them a survival edge. Another possible outcome of positive selection in zinc finger proteins is the emergence of new genetic variations that allow for increased diversity and plasticity in stem cells. This increased diversity and plasticity could have allowed for more efficient adaptation to changing environments and could have played a role in the evolution of new organisms or new characteristics in existing organisms. Overall, the results of positive selection in zinc finger proteins can provide insight into how adaptive evolution occurred in undifferentiated stem cells during the evolution of mammals and how this evolution may have contributed to the development of new organisms and new characteristics and adaptations to changing environments.
    Type of Medium: Online Resource
    ISSN: 1439-0469 , 0947-5745
    URL: Article
    DOI: 10.1155/2023/6693488
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1208940-0
    detail.hit.zdb_id: 2021279-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Potential Probiotics Role in Excluding Antibiotic Resistance
    Wiley ; 2022
    In:  Journal of Food Quality Vol. 2022 ( 2022-10-14), p. 1-20
    Details
    In: Journal of Food Quality, Wiley, Vol. 2022 ( 2022-10-14), p. 1-20
    Abstract: Background. Antibiotic supplementation in feed has been continued for the previous 60 years as therapeutic use. They can improve the growth performance and feed efficiency in the chicken flock. A favorable production scenario could favor intestinal microbiota interacting with antibiotic growth promoters and alter the gut bacterial composition. Antibiotic growth promoters did not show any beneficial effect on intestinal microbes. Scope and Approach. Suitable and direct influence of growth promoters are owed to antimicrobial activities that reduce the conflict between host and intestinal microbes. Unnecessary use of antibiotics leads to resistance in microbes, and moreover, the genes can relocate to microbes including Campylobacter and Salmonella, resulting in a great risk of food poisoning. Key Findings and Conclusions. This is a reason to find alternative dietary supplements that can facilitate production, growth performance, favorable pH, and modulate gut microbial function. Therefore, this review focus on different nutritional components and immune genes used in the poultry industry to replace antibiotics, their influence on the intestinal microbiota, and how to facilitate intestinal immunity to overcome antibiotic resistance in chicken.
    Type of Medium: Online Resource
    ISSN: 1745-4557 , 0146-9428
    URL: Article
    DOI: 10.1155/2022/5590004
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2175284-9
    detail.hit.zdb_id: 428332-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    [Retracted] In Silico Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family
    Wiley ; 2021
    In:  BioMed Research International Vol. 2021, No. 1 ( 2021-01)
    Details
    In: BioMed Research International, Wiley, Vol. 2021, No. 1 ( 2021-01)
    Abstract: Cytochrome (CYP) enzymes catalyze the metabolic reactions of endogenous and exogenous compounds. The superfamily of enzymes is found across many organisms, regardless of type, except for plants. Information was gathered about CYP2D enzymes through protein sequences of humans and other organisms. The secondary structure was predicted using the SOPMA. The structural and functional study of human CYP2D was conducted using ProtParam, SOPMA, Predotar 1.03, SignalP, TMHMM 2.0, and ExPASy. Most animals shared five central motifs according to motif analysis results. The tertiary structure of human CYP2D, as well as other animal species, was predicted by Phyre2. Human CYP2D proteins are heavily conserved across organisms, according to the findings. This indicates that they are descended from a single ancestor. They calculate the ratio of alpha‐helices to extended strands to beta sheets to random coils. Most of the enzymes are alpha‐helix, but small amounts of the random coil were also found. The data were obtained to provide us with a better understanding of mammalian proteins’ functions and evolutionary relationships.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Issue
    URL: Article
    DOI: 10.1155/bmri.v2021.1
    DOI: 10.1155/2021/5574789
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
    detail.hit.zdb_id: 2705584-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    [Retracted] Assessment of Acupoint Therapy of Traditional Chinese Medicine on Cough Variant Asthma: A Meta‐analysis
    Wiley ; 2022
    In:  BioMed Research International Vol. 2022, No. 1 ( 2022-01)
    Details
    In: BioMed Research International, Wiley, Vol. 2022, No. 1 ( 2022-01)
    Abstract: Acupoint application has been used in China to treat various illnesses for ages. In cough variant asthma (CVA), the main clinical sign is episodic night cough. Acupoint application therapy of traditional Chinese medicine is an effective procedure to treat cough variant asthma. The current study is designed to systematically assess the effectiveness of acupoint application therapy in traditional medicine for patients with cough variant asthma. The comprehensive computer retrieval related to comparison between acupoint application and nonacupoint application therapy for cough variant asthma was carried out in various databases ( n = 8) from database establishment until July 4, 2021. Both English and Chinese articles about original investigations in humans were searched. Two independent authors extracted the data, and disagreements were resolved by discussion. ReviewManager 5.3 software provided by Cochrane did a meta‐analysis of selected randomized controlled trials (RCTs). Quality of experimentation and risk bias were analyzed by the Cochrane Handbook tool. A total of thirteen randomized controlled clinical articles along with 1237 patients were included in the study. Findings of meta‐analysis showed that compared with nonacupoint application treatment, the total effective rate of acupoint application treatment is more effective (RD = 0.13, 95% CI (0.09, 0.17), Z = 6.70, P 〈 0.00001). Besides, acupoint application can improve patients’ lung function, the lung function index FVC (mean difference = 0.55, 95% confidence interval (0.42, 0.68), Z = 8.40, P 〈 0.00001), FEV1 (MD = 0.35, 95% CI (0.23, 0.47), Z = 5.86, P 〈 0.00001), FEV1/FVC (%) (MD = 12.68, 95% CI (4.32, 21.03), Z = 2.97, P = 0.003), FEV1 (%) (MD = 8.63, 95% CI (8.01, 9.25), Z = 27.44, P 〈 0.00001), and PEF (day) (MD = 0.62, 95% CI (0.52, 0.71), Z = 12.40, P 〈 0.00001) of patients treated by acupoint application therapy were increased. Moreover, acupoint application might lower the level of immunoglobulin E (MD = −54.58, 95% CI (−63.54, −45.61), Z = 11.93, P 〈 0.00001) and EOS (MD = −0.21, 95% CI (−0.35, −0.06), Z = 2.77, P = 0.006). The LCQ (Leicester cough questionnaire) total score of CVA patients was also increased (MD = 2.30, 95% CI (1.55, 3.06), Z = 5.98, P 〈 0.00001). Acupoint application therapy is effective in controlling symptoms of CVA. It also has a positive effect in improving lung function and life quality of patients. It can reduce the eosinophil levels and peripheral blood IgE levels of patients as well.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Issue
    URL: Article
    DOI: 10.1155/bmri.v2022.1
    DOI: 10.1155/2022/4168308
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
    detail.hit.zdb_id: 2705584-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Structural and Evolutionary Adaptations of Nei-Like DNA Glycosylases Proteins Involved in Base Excision Repair of Oxidative DNA Damage in Vertebrates
    Wiley ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-4-4), p. 1-20
    Details
    In: Oxidative Medicine and Cellular Longevity, Wiley, Vol. 2022 ( 2022-4-4), p. 1-20
    Abstract: Oxidative stress is a type of stress that damages DNA and can occur from both endogenous and exogenous sources. Damage to DNA caused by oxidative stress can result in base modifications that promote replication errors and the formation of sites of base loss, which pose unique challenges to the preservation of genomic integrity. However, the adaptive evolution of the DNA repair mechanism is poorly understood in vertebrates. This research aimed to explore the evolutionary relationships, physicochemical characteristics, and comparative genomic analysis of the Nei-like glycosylase gene family involved in DNA base repair in the vertebrates. The genomic sequences of NEIL1, NEIL2, and NEIL3 genes were aligned to observe selection constraints in the genes, which were relatively low conserved across vertebrate species. The positive selection signals were identified in these genes across the vertebrate lineages. We identified that only about 2.7% of codons in these genes were subjected to positive selection. We also revealed that positive selection pressure was increased in the Fapy-DNA-glyco and H2TH domain, which are involved in the base excision repair of DNA that has been damaged by oxidative stress. Gene structure, motif, and conserved domain analysis indicated that the Nei-like glycosylase genes in mammals and avians are evolutionarily low conserved compared to other glycosylase genes in other “vertebrates” species. This study revealed that adaptive selection played a critical role in the evolution of Nei-like glycosylase in vertebrate species. Systematic comparative genome analyses will give key insights to elucidate the links between DNA repair and the development of lifespan in various organisms as more diverse vertebrate genome sequences become accessible.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/1144387
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Avian Diversity and Abundance of Taunsa Barrage Ramsar Site in Punjab, Pakistan
    Wiley ; 2022
    In:  Journal of Zoological Systematics and Evolutionary Research Vol. 2022 ( 2022-5-19), p. 1-14
    Details
    In: Journal of Zoological Systematics and Evolutionary Research, Wiley, Vol. 2022 ( 2022-5-19), p. 1-14
    Abstract: The study of avian species diversity and abundance at the Taunsa Barrage Ramsar site was carried out from September 2019 to March 2020. Taunsa Barrage is an important wetland for international and local migratory birds, including waterfowls, waders, and long-distance migrant avifauna. Data were collected by direct counts made on four-point transects representing a disturbance gradient due to humans and different habitats. Species diversity indices, analysis of variance (ANOVA), and other statistical methods were used to analyze data. A total of 150 avian species of 19 orders and 53 families were recorded. These included 66 migrant species and 84 resident species. The spotting of ten globally threatened species also highlights the importance of wetland for avian species. On average, 1511 ± 373 ( mean ± SD ) species of birds were recorded every month. Shannon’s diversity index indicated that Transect Point 2 had higher species diversity ( H ′ = 3.779 ), followed by Transect Points 3, 4, and 1 ( H ′ = 3.769 , H ′ = 3.491 , and H ′ = 3.457 , respectively). Evenness index showed that birds evenly distributed in September ( E = 0.5584 ) than November ( E = 0.310 9). ANOVA showed a significant difference ( F = 4.800 , df = 3 , P = 0.002 ) of avian diversity and abundance among the transect points. But there was no statistically significant interaction between months ( F = 1.23 , df = 6 , P = 0.233 ). The results showed that the Taunsa Barrage Ramsar site harbors plenty of resident migratory and threatened bird species. Hence, it is important to protect its habitat and need to protect avian diversity by overcoming major threats.
    Type of Medium: Online Resource
    ISSN: 1439-0469 , 0947-5745
    URL: Article
    DOI: 10.1155/2022/4736195
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1208940-0
    detail.hit.zdb_id: 2021279-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    [Retracted] Empirical Method for Thyroid Disease Classification Using a Machine Learning Approach
    Wiley ; 2022
    In:  BioMed Research International Vol. 2022, No. 1 ( 2022-01)
    Details
    In: BioMed Research International, Wiley, Vol. 2022, No. 1 ( 2022-01)
    Abstract: There are many thyroid diseases affecting people all over the world. Many diseases affect the thyroid gland, like hypothyroidism, hyperthyroidism, and thyroid cancer. Thyroid inefficiency can cause severe symptoms in patients. Effective classification and machine learning play a significant role in the timely detection of thyroid diseases. This timely classification will indeed affect the timely treatment of the patients. Automatic and precise thyroid nodule detection in ultrasound pictures is critical for reducing effort and radiologists’ mistake rate. Medical images have evolved into one of the most valuable and consistent data sources for machine learning generation. In this paper, various machine learning algorithms like decision tree, random forest algorithm, KNN, and artificial neural networks on the dataset create a comparative analysis to better predict the disease based on parameters established from the dataset. Also, the dataset has been manipulated for accurate prediction for the classification. The classification was performed on both the sampled and unsampled datasets for better comparison of the dataset. After dataset manipulation, we obtained the highest accuracy for the random forest algorithm, equal to 94.8% accuracy and 91% specificity.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Issue
    URL: Article
    DOI: 10.1155/bmri.v2022.1
    DOI: 10.1155/2022/9809932
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
    detail.hit.zdb_id: 2705584-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Hematobiochemical, Oxidative Stress, and Histopathological Mediated Toxicity Induced by Nickel Ferrite (NiFe2O4) Nanoparticles in Rabbits
    Wiley ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-3-11), p. 1-14
    Details
    In: Oxidative Medicine and Cellular Longevity, Wiley, Vol. 2022 ( 2022-3-11), p. 1-14
    Abstract: From the past few decades, attention towards the biological evaluation of nanoparticles (NPs) has increased due to the persistent and extensive application of NPs in various fields, including biomedical science, modern industry, magnetic resonance imaging, and the construction of sensors. Therefore, in the current study, magnetic nickel ferrite (NiFe2O4) nanoparticles (NFNPs) were synthesized and evaluated for their possible adverse effects in rabbits. The crystallinity of the synthesized NFNPs was confirmed using X-ray diffraction (XRD) technique. The saturation magnetization (46.7 emug-1) was measured using vibrating sample magnetometer (VSM) and 0.35-tesla magnetron by magnetic resonance imaging (MRI). The adverse effects of NFNPs on blood biochemistry and histoarchitecture of the liver, kidneys, spleen, brain, and heart of the rabbits were determined. A total of sixteen adult rabbits, healthy and free from any apparent infection, were blindly placed in two groups. The rabbits in group A served as control, while the rabbits in group B received a single dose (via ear vein) of NFNPs for ten days. The blood and visceral tissues were collected from each rabbit at days 5 and 10 of posttreatment. The results on blood and serum biochemistry profile indicated significant variation in hematological and serum biomarkers in NFNP-treated rabbits. The results showed an increased quantity of oxidative stress and depletion of antioxidant enzymes in treated rabbits. Various serum biochemical tests exhibited significantly higher concentrations of different liver function tests, kidney function tests, and cardiac biomarkers. Histopathologically, the liver showed congestion, edema, atrophy, and degeneration of hepatocytes. The kidneys exhibited hemorrhages, atrophy of renal tubule, degeneration, and necrosis of renal tubules, whereas coagulative necrosis, neutrophilic infiltration, and severe myocarditis were seen in different sections of the heart. The brain of the treated rabbits revealed necrosis of neurons, neuron atrophy, and microgliosis. In conclusion, the current study results indicated that the highest concentration of NPs induced adverse effects on multiple tissues of the rabbits.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/5066167
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...