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  • 1
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    Online Resource
    Modeling of the angular distribution of the emitted molecular flux from a cylindrical nozzle in a free molecular flow
    Wiley ; 2018
    In:  Journal of the Society for Information Display Vol. 26, No. 12 ( 2018-12), p. 708-723
    Details
    In: Journal of the Society for Information Display, Wiley, Vol. 26, No. 12 ( 2018-12), p. 708-723
    Abstract: In the linear source of a thermal evaporation system, the thickness of the deposited molecules depends on the angular distribution of the emitted molecular flux from the nozzle. According to Knudsen in 1907, for a cylindrical nozzle, the angular distribution of the emitted molecular flux can be expressed in the form of cos n ( θ ) . The actual angular distribution, however, does not precisely match the form of cos n ( θ ) by Knudsen. Therefore, various theoretical methods have been studied in an effort to express the angular distribution of the emitted molecular flux mathematically. Using these conventional methods can allow one to determine the accurate angular distribution of the emitted molecular flux, but the same calculation should be repeated whenever the shape of the nozzle changes, as the angular distribution acquired by these methods is not an “analytical solution” but a “numerical solution.” In this paper, an analytical model of the accurate angular distribution determined via an approximation method is proposed to make the nozzle array optimization processes of linear sources faster and more accurate for a cylindrical nozzle. The model is verified through a comparison involving the direct simulation Monte Carlo method and an experiment with a point evaporation source.
    Type of Medium: Online Resource
    ISSN: 1071-0922 , 1938-3657
    URL: Issue
    URL: Article
    DOI: 10.1002/jsid.v26.12
    DOI: 10.1002/jsid.731
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2190777-8
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  • 2
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    Plum Prevents Intestinal and Hepatic Inflammation in the Acute and Chronic Models of Dextran Sulfate Sodium‐Induced Mouse Colitis
    Wiley ; 2022
    In:  Molecular Nutrition & Food Research Vol. 66, No. 13 ( 2022-07)
    Details
    In: Molecular Nutrition & Food Research, Wiley, Vol. 66, No. 13 ( 2022-07)
    Abstract: Inflammatory bowel disease (IBD), including ulcerative colitis (UC), is a chronic recurrent inflammatory disease of the digestive tract and increases the risk of colon cancer. Method and Results This study evaluates the effects of dietary intervention with freeze‐dried plum (FDP), a natural antioxidant and anti‐inflammatory fruit with no toxicity on dextran sulfate sodium (DSS)‐induced acute and chronic experimental colitis in a mouse model and studies the molecular mechanisms of protection through the gut–liver axis. The results show that FDP decreases the levels of inflammatory mediators, which is a nitrative stress biomarker in both acute and chronic models. FDP markedly reduces DSS‐induced injury to the colonic epithelium in both acute and chronic models. In addition, FDP significantly decreases the levels of pro‐oxidant markers such as CYP2E1, iNOS, and nitrated proteins (detected by anti‐3‐NT antibody) in DSS‐induced acute and chronic colonic injury models. Furthermore, FDP markedly reduces markers of liver injury such as serum ALT/AST, antioxidant markers, and inflammatory mediators in DSS‐induced acute and chronic colonic injury. Conclusion These results demonstrate that the FDP exhibits a protective effect on DSS‐induced acute and chronic colonic and liver injury through the gut–liver axis via antioxidant and anti‐inflammatory properties.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    URL: Article
    DOI: 10.1002/mnfr.v66.13
    DOI: 10.1002/mnfr.202101049
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2160372-8
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  • 3
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    A phase 4 study of nilotinib in Korean patients with Philadelphia chromosome‐positive chronic myeloid leukemia in chronic phase: ENESTK orea
    Wiley ; 2018
    In:  Cancer Medicine Vol. 7, No. 5 ( 2018-05), p. 1814-1823
    Details
    In: Cancer Medicine, Wiley, Vol. 7, No. 5 ( 2018-05), p. 1814-1823
    Abstract: Although nilotinib has improved efficacy compared to imatinib, suboptimal response and intolerable adverse events ( AE s) limit its effectiveness in many patients with chronic myeloid leukemia in chronic phase ( CML ‐ CP ). We investigated the 2‐year efficacy and safety of nilotinib and their relationships with plasma nilotinib concentrations ( PNC s). In this open‐label, multi‐institutional phase 4 study, 110 Philadelphia chromosome‐positive CML ‐ CP patients were treated with nilotinib at a starting dose of 300 mg twice daily. Molecular responses ( MR s) and AE s were monitored for up to 24 months. The 24‐month cumulative MR 4.5 rate was evaluated as the primary endpoint. Plasma samples were collected from 94 patients to determine PNC s, and the per‐patient mean was used to categorize them into four mean PNC ( MPNC ) groups. Cumulative MR rates and safety were compared between groups. With a median follow‐up of 22.2 months, the 24‐month cumulative MR 4.5 rate was 56.2% (95% confidence interval, 44.0%–8.3%), and the median time to MR 4.5 was 23.3 months. There were no significant differences in the cumulative rates of major molecular response, MR 4 , and MR 4.5 between MPNC groups. One patient died due to acute viral hepatitis, and two developed hematological or cytogenetic relapse, while no progression to accelerated or blast phase was observed. Safety results were consistent with previous studies with no new safety signal identified. Across the MPNC groups, there was no significant linear trend in the frequency of AE s. Nilotinib is highly effective for the treatment of CML ‐ CP with manageable AE s. The measurement of PNC has no predictive value for patient outcomes and is thus not found to be clinically useful. This study is registered with clinicaltrials.gov, Number NCT 03332511.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.2018.7.issue-5
    DOI: 10.1002/cam4.1450
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2659751-2
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  • 4
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    Deformation characteristics of hydrogel products based on cross‐linked hyaluronic acid
    Wiley ; 2023
    In:  Journal of Cosmetic Dermatology
    Details
    In: Journal of Cosmetic Dermatology, Wiley
    Abstract: The cross‐linked hyaluronic acid (HA) fillers are the viscoelastic hydrogel with a dominant elasticity rather than a viscosity as a useful medical device in the soft tissue augmentation. These HA fillers undergo deformation to begin the biodegradation by the biochemical and physical environment of the body, and result of deformations are closely related to clinical performance. Aims The specific equation of molding index is newly generated and proved with Collin's equation, which is used for strong elastomers, for selecting optimal product in facial treatment. Methods In this study, the results of amplitude sweep test from five marketed HA fillers were mathematically demonstrated for the proper clinical application. Results The increment of loss modulus by deformation was evaluated as a useful factor for the maintenance of optimal shape molding performance and resistance to external deformation of the cross‐linked HA gel. From this study, the equation of molding index for weak viscoelastic hydrogels like HA products can be applied for choosing which products even in aesthetic plastic field. This molding index equation is compared to Collins' equation that index of deformation as elastomer like rubber and then found the positive correlation between two equations. Conclusion This study could provide a basic theory that achieve useful clinical performance according to characteristics among many types of medical devices based on the molding index.
    Type of Medium: Online Resource
    ISSN: 1473-2130 , 1473-2165
    URL: Article
    DOI: 10.1111/jocd.15801
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2075528-4
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  • 5
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    Molecular cloning of a novel GTP‐binding protein induced in fish cells by rhabdovirus infection
    Wiley ; 1998
    In:  FEBS Letters Vol. 429, No. 3 ( 1998-06-16), p. 407-411
    Details
    In: FEBS Letters, Wiley, Vol. 429, No. 3 ( 1998-06-16), p. 407-411
    Abstract: We have cloned and sequenced a cDNA encoding GTP‐binding protein from a fish cell, CHSE‐214. The clone was 1493 bp long and contained an open reading frame encoding 364 amino acids. It has the five sequence motifs G1–G5 that are conserved in all GTP‐binding proteins. Its amino acid sequences are strikingly different from those of the well‐characterized G‐proteins. However, sequences closely related to this protein are found in various kinds of species including human, Arabidopsis , Drosophila and archaebacteria, suggesting a novel subfamily within the superfamily of the GTP‐binding proteins. Northern analysis indicates that this gene is constitutively expressed at a low level in normal cells but is induced by fish rhabdovirus infection at about 24 h post infection and disappears thereafter. Based on these observations, we propose that this protein represents an evolutionarily conserved novel subfamily of GTP‐binding proteins which may play an important role in fish rhabdovirus infection.
    Type of Medium: Online Resource
    ISSN: 0014-5793 , 1873-3468
    URL: Article
    DOI: 10.1016/S0014-5793(98)00641-3
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 1998
    detail.hit.zdb_id: 1460391-3
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  • 6
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    Efficiency of a New Mesh‐Type Nebulizer ( NE ‐ SM 1 NEPLUS ) for Intrapulmonary Delivery of Ipratropium Bromide in Surgical Patients
    Wiley ; 2016
    In:  Basic & Clinical Pharmacology & Toxicology Vol. 118, No. 4 ( 2016-04), p. 313-319
    Details
    In: Basic & Clinical Pharmacology & Toxicology, Wiley, Vol. 118, No. 4 ( 2016-04), p. 313-319
    Abstract: This study was aimed to evaluate the efficiency of a new mesh‐type nebulizer for the intrapulmonary delivery of ipratropium bromide in surgical patients under mechanical ventilation. A total of 20 patients were randomly allocated to receive 0.5 mg ipratropium bromide using either a control (Pariboy SX , Pari, Co., Starnberg, Germany, n = 10) or test ( NE ‐ SM 1 NEPLUS , KTMED INC., Seoul, Korea, n = 10) nebulizer during general anaesthesia. Ipratropium bromide was nebulized continuously for 20 min. in each group. Plasma concentrations of ipratropium bromide were obtained from blood samples at preset intervals. Non‐compartmental analysis of ipratropium bromide was performed to compare the efficiency of pulmonary drug delivery in both nebulizers. Population pharmacokinetic analysis of ipratropium bromide was performed. Additionally, the noise level during the nebulizer operation and the aerosol particle size for each device were measured. The dose‐normalized AUC last was 0.10 min/L for both nebulizers. The pharmacokinetics of nebulized ipratropium bromide can be described best by a one‐compartment model with first‐order absorption. The apparent volume of distribution and metabolic clearance were 1340 L and 6.78 L/min, respectively. Type of nebulizer was a significant covariate for absorption rate constant. The equivalent sound level and median aerosol particle diameter were 35.0 dB and 4.52 μm for the test nebulizer, and 60.2 dB and 3.85 μm for the control nebulizer, respectively. From the standpoint of the dose‐normalized AUC last , a new vibrating mesh‐type nebulizer shows similar performance in the intrapulmonary delivery of ipratropium bromide to that of a jet‐type nebulizer in surgical patients.
    Type of Medium: Online Resource
    ISSN: 1742-7835 , 1742-7843
    URL: Issue
    URL: Article
    DOI: 10.1111/bcpt.2016.118.issue-4
    DOI: 10.1111/bcpt.12499
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2151592-X
    SSG: 15,3
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  • 7
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    Discovery of gastric cancer specific biomarkers by the application of serum proteomics
    Wiley ; 2017
    In:  PROTEOMICS Vol. 17, No. 6 ( 2017-03)
    Details
    In: PROTEOMICS, Wiley, Vol. 17, No. 6 ( 2017-03)
    Abstract: Current diagnostic markers for gastric cancer are not sufficiently specific or sensitive for use in clinical practice. The aims of this study are to compare the proteomes of serum samples from patients with gastric cancers and normal controls, and to develop useful tumor markers of gastric cancer by quantitative proteomic analysis. We identified a total of 388 proteins with a ≤1% FDR and with at least two unique peptides from the sera of each group. Among them, 215, 251, and 260 proteins were identified in serum samples of patients in an advanced cancer group, early cancer group, and normal control group, respectively. We selected differentially expressed proteins in cancer patients compared with those of normal controls via semiquantitative analyses comparing the spectral counts of identified proteins. These differentially expressed proteins were successfully verified using an MS‐based quantitative assay, multiple reactions monitoring analysis. Four proteins (vitronectin, clusterin isoform 1, thrombospondin 1, and tyrosine‐protein kinase SRMS) were shown to have significant changes between the cancer groups and the normal control group. These four serum proteins were able to discriminate gastric cancer patients from normal controls with sufficient specificity and selectivity.
    Type of Medium: Online Resource
    ISSN: 1615-9853 , 1615-9861
    URL: Issue
    URL: Article
    DOI: 10.1002/pmic.v17.6
    DOI: 10.1002/pmic.201600332
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2037674-1
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  • 8
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    Validation of prognostic scores to predict short‐term mortality in patients with acute‐on‐chronic liver failure
    Wiley ; 2018
    In:  Journal of Gastroenterology and Hepatology Vol. 33, No. 4 ( 2018-04), p. 900-909
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 33, No. 4 ( 2018-04), p. 900-909
    Abstract: The aim of this study was to validate the chronic liver failure‐sequential organ failure assessment score (CLIF‐SOFAs), CLIF consortium organ failure score (CLIF‐C OFs), CLIF‐C acute‐on‐chronic liver failure score (CLIF‐C ACLFs), and CLIF‐C acute decompensation score in Korean chronic liver disease patients with acute deterioration. Methods Acute‐on‐chronic liver failure was defined by either the Asian Pacific Association for the study of the Liver ACLF Research Consortium (AARC) or CLIF‐C criteria. The diagnostic performances for short‐term mortality were compared by the area under the receiver operating characteristic curve. Results Among a total of 1470 patients, 252 patients were diagnosed with ACLF according to the CLIF‐C (197 patients) or AARC definition (95 patients). As the ACLF grades increased, the survival rates became significantly lower. The areas under the receiver operating characteristic of the CLIF‐SOFAs, CLIF‐C OFs, and CLIF‐C ACLFs were significantly higher than those of the Child–Pugh, model for end‐stage liver disease, and model for end‐stage liver disease‐Na scores in ACLF patients according to the CLIF‐C definition (all P   〈  0.05), but there were no significant differences in patients without ACLF or in patients with ACLF according to the AARC definition. The CLIF‐SOFAs, CLIF‐C OFs, and CLIF‐C ACLFs had higher specificities with a fixed sensitivity than liver specific scores in ACLF patients according to the CLIF‐C definition, but not in ACLF patients according to the AARC definition. Conclusions The CLIF‐SOFAs, CLIF‐C OFs, and CLIF‐C ACLFs are useful scoring systems that provide accurate information on prognosis in patients with ACLF according to the CLIF‐C definition, but not the AARC definition.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2018.33.issue-4
    DOI: 10.1111/jgh.13991
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2006782-3
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  • 9
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    The design and realization of a highly linear power amplifier module for a WiMAX/WiBro (802.16 e ) base station
    Wiley ; 2010
    In:  Microwave and Optical Technology Letters Vol. 52, No. 9 ( 2010-09), p. 1952-1955
    Details
    In: Microwave and Optical Technology Letters, Wiley, Vol. 52, No. 9 ( 2010-09), p. 1952-1955
    Abstract: We have designed and realized a highly linear power amplifier module (PAM) for a WiMAX/WiBro base station using a simple linearization method. To improve the linearity of the PAM, we use large‐signal intermodulation distortion (IMD) sweet spots, which are part of the inherent properties of power transistors. These IMD sweet spots are determined by the device technologies and the bias voltage. Our PAM consists of a drive stage and a power stage. Two amplifiers are used in the drive stage, a GaAs field effect transistor (GaAs FET) and a laterally diffused metal oxide semiconductor. The linearity of the PMA can be maximally improved by the large‐signal IMD sweet spots, which are tuned by the bias voltage of the GaAs FET at the signal power input of the drive stage. Using this method, the measured adjacent channel leakage ratio and power consumption efficiency of the PAM are improved by 2.9 dBc and 5.2%, respectively. The measured error vector magnitude of the PAM is only 1.45. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1952–1955, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25374
    Type of Medium: Online Resource
    ISSN: 0895-2477 , 1098-2760
    URL: Issue
    URL: Article
    DOI: 10.1002/mop.v52:9
    DOI: 10.1002/mop.25374
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2000574-X
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  • 10
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    Aripiprazole plus divalproex for recently manic or mixed patients with bipolar I disorder: a 6‐month, randomized, placebo‐controlled, double‐blind maintenance trial
    Wiley ; 2011
    In:  Human Psychopharmacology: Clinical and Experimental Vol. 26, No. 8 ( 2011-12), p. 543-553
    Details
    In: Human Psychopharmacology: Clinical and Experimental, Wiley, Vol. 26, No. 8 ( 2011-12), p. 543-553
    Abstract: The goal of this study was to investigate the safety and efficacy in preventing relapse of a mood episode in recently manic or mixed episode patients with bipolar I disorder stabilized with aripiprazole and divalproex combination. Methods This randomized, 24‐week, double‐blind, placebo‐controlled multicenter study enrolled patients from 23 centers in Korea. Patients with bipolar I disorder who had manic or mixed episode entered a 6‐week open‐label stabilization phase. After meeting stabilization criteria, 83 patients were randomly assigned to placebo + divalproex or aripiprazole + divalproex treatment group for the 24‐week, double‐blind maintenance phase. Results During the 6‐month double‐blind treatment, the time to relapse of any mood episode in the aripiprazole group was longer than the placebo group, but the difference did not reach statistical significance ( p = 0.098). After controlling for mean divalproex level, the time to depressive episode relapse in the aripiprazole group was longer than those in the placebo group ( p = 0.029). Weight gain (≥7% increase) occurred in 22.5% aripiprazole group and 18.6% placebo group ( p = 0.787). Conclusions In this study, relapse of mood episode occurred fewer and later for aripiprazole with divalproex treatment than divalproex monotherapy, but the differences were not statistically significant. Copyright © 2011 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0885-6222 , 1099-1077
    URL: Issue
    URL: Article
    DOI: 10.1002/hup.v26.8
    DOI: 10.1002/hup.1240
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2001446-6
    SSG: 15,3
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