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  • 1
    Online Resource
    Online Resource
    Prompt admission to intensive care is associated with improved survival in patients with severe sepsis and/or septic shock
    SAGE Publications ; 2018
    In:  Journal of International Medical Research Vol. 46, No. 10 ( 2018-10), p. 4071-4081
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 46, No. 10 ( 2018-10), p. 4071-4081
    Abstract: To investigate the association between time from hospital admission to intensive care unit (ICU) admission (door to ICU time) and hospital mortality in patients with sepsis. Methods This retrospective observational study included routinely collected healthcare data from patients with sepsis. The primary endpoint was hospital mortality, defined as the survival status at hospital discharge. Door to ICU time was calculated and included in a multivariable model to investigate its association with mortality. Results Data from 13 115 patients were included for analyses, comprising 10 309 survivors and 2 806 non-survivors. Door to ICU time was significantly longer for non-survivors than survivors (median, 43.0 h [interquartile range, 12.4, 91.3] versus 26.7 h [7.0, 74.2] ). In the multivariable regression model, door to ICU time remained significantly associated with mortality (odds ratio [OR] 1.11, 95% confidence interval [CI] 1.006, 1.017) and there was a significant interaction between age and door to ICU time (OR 0.99, 95% CI 0.99, 1.00). Conclusion A shorter time from hospital door to ICU admission was shown to be independently associated with reduced hospital mortality in patients with severe sepsis and/or septic shock.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060518781253
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2082422-1
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  • 2
    Online Resource
    Online Resource
    Location-assistant content distribution scheme for emergency rescue
    SAGE Publications ; 2018
    In:  International Journal of Distributed Sensor Networks Vol. 14, No. 9 ( 2018-09), p. 155014771880046-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 14, No. 9 ( 2018-09), p. 155014771880046-
    Abstract: In order to optimize the timeliness and pertinence of message delivery in emergency rescue scenarios and improve the service performance of emergency communications network, we propose a location-assistant content distribution scheme based on delay tolerant network. First of all, considering that the movement patterns of rescue teams tend to follow a predetermined course of action, we design a location-based group mobility model. Due to the intermittent network connectivity and variety of emergency service, a content-classification-based publish/subscribe architecture and a GenericSpray routing algorithm based on the prediction of overlap opportunity in spatio-temporal positions are proposed. Furthermore, we also give a cache management strategy based on the content significance. Since location-assistant content distribution scheme can predict the overlap of activity between rescue teams through the course of action, not only can the number of copy forwarding and message delivery delays be significantly reduced but also the priority delivery of important messages can be ensured by message classification. Simulation experiments show that compared with the traditional delay tolerant network routing algorithm and the classic first-in-first-out caching strategy, location-assistant content distribution scheme improves the performance of message delivery rate, transmission delay, and control overhead significantly.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1177/1550147718800464
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2192922-1
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  • 3
    Online Resource
    Online Resource
    miR-218-5p inhibits the malignant progression of glioma via targeting TCF12
    SAGE Publications ; 2022
    In:  Tumori Journal Vol. 108, No. 4 ( 2022-08), p. 338-346
    Details
    In: Tumori Journal, SAGE Publications, Vol. 108, No. 4 ( 2022-08), p. 338-346
    Abstract: Several studies have shown the ability of transcription factor 12 (TCF12) to promote tumor malignant progression, but its function in glioma cells has not been fully elucidated. In this study, we analyzed the data from TCGA by bioinformatics and found that in glioma tissue, TCF12 was conspicuously highly expressed while miR-218-5p was significantly low-expressed. The downregulation of miR-218-5p was correlated with adverse prognosis in patients with glioma. miR-218-5p was found to be negatively associated with TCF12 by Pearson correlation analysis, and dual luciferase assay was employed to verify that miR-218-5p and TCF12 had a targeting relationship. qRT-PCR and Western blot assays were used to verify that the expression of TCF12 was regulated by its upstream regulator miR-218-5p. Moreover, cell experiments validated that overexpressed TCF12 could promote the proliferation, migration, and invasion of glioma cells and inhibit their apoptosis, whereas overexpressing miR-218-5p at the same time could reverse this phenomenon. Our study demonstrates the regulatory mechanism of the miR-218-5p/TCF12 axis in gliomas, which lays a foundation for searching for new therapeutic approaches for glioma.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/03008916211018263
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 4
    Online Resource
    Online Resource
    Study on the influence of middle school students’ self-efficacy on the willingness to use online learning platform
    SAGE Publications ; 2021
    In:  The International Journal of Electrical Engineering & Education
    Details
    In: The International Journal of Electrical Engineering & Education, SAGE Publications
    Abstract: People’s learning style is constantly changing together with the rapid development of information technology. Nowadays, online learning has become a common learning style, but online learning resource providers are also faced with the charging issue. Besides, a large number of studies have been made by scholars at home and abroad in this field. In this paper, the influence of middle school students’ self-efficacy on online learning resource purchase intention is analyzed, and the study comprises two stages. To be specific, in the first stage, the interview method is adopted to acquire related materials, and the grounded theory is also followed to reconstruct the theoretical research framework; in the second stage, the theoretical framework is empirically verified by the questionnaire. Then, it is found that middle school students’ self-efficacy affects the identity about online learning resources’ perceived quality and their purchase intention for online learning resources. At the same time, the teacher-student relation may also reinforce students’ purchase intention for online learning resources. Thus, it can be seen that online learning resources’ perceived quality and the intimate teacher-student relation have significant influence on middle school students’ purchase intention.
    Type of Medium: Online Resource
    ISSN: 0020-7209 , 2050-4578
    URL: Article
    DOI: 10.1177/0020720920984030
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2026370-3
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  • 5
    Online Resource
    Online Resource
    Repair of Asymmetric Bilateral Cleft lip: 1 Stage or 2 Stage
    SAGE Publications ; 2022
    In:  The Cleft Palate-Craniofacial Journal Vol. 59, No. 4 ( 2022-04), p. 436-441
    Details
    In: The Cleft Palate-Craniofacial Journal, SAGE Publications, Vol. 59, No. 4 ( 2022-04), p. 436-441
    Abstract: To verify the advantages and indications of 1-stage and 2-stage repair for asymmetric bilateral cleft lip (BCL). Design: Retrospective study. Setting: From January 2004 to December 2016 in our department. Patients: Patients with BCL. Main Outcome Measure(s): Over 6 months after the operation, the surgery outcomes were evaluated and graded by 2 experienced surgeons. Results: The result of surgery was evaluated using the scoring method of Mortier et al and Anastassov and Chipkov. Among 133 patients with asymmetric BCL, 61 (45.9%) had 1-stage repair and 72 (54.1%) had 2-stage repair. Sixty-eight (51.1%) patients had complete-incomplete cleft lip (CL), and those who underwent 1-stage repair showed a trend of better outcome ( P = .028). Fifty (37.6%) patients with incomplete-microform CL showed no significant difference between the outcomes of 2 surgery plans ( P = .253). In 15 (11.3%) patients with complete-microform CL, only one had 1-stage repair with a score of 8.5. The other 14 patients with 2-stage repair were scored 3.68 ± 1.28. Two-stage repair was preferable when the deformity degree was very different on 2 sides, as it could reduce unnecessary scar tissue and extend the nasal columella. One-stage repair could help to achieve the anatomical reduction of the orbicularis oris and a better contour of the vermilion tubercle. Conclusion: One-stage repair is recommended for patients with complete-incomplete CL and incomplete-microform CL. Two-stage repair for patients with complete-microform CL is preferred in our center, but more studies are required to support this conclusion.
    Type of Medium: Online Resource
    ISSN: 1055-6656 , 1545-1569
    URL: Article
    DOI: 10.1177/10556656211013978
    RVK:
    XA 36625
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2030056-6
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  • 6
    Online Resource
    Online Resource
    Lenalidomide Enhances CAR-T Cell Activity Against Solid Tumor Cells
    SAGE Publications ; 2020
    In:  Cell Transplantation Vol. 29 ( 2020-01-01), p. 096368972092082-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 29 ( 2020-01-01), p. 096368972092082-
    Abstract: Chimeric antigen receptor (CAR) T-cell immunotherapy still faces many challenges in the treatment of solid tumors, one of which is T-cell dysfunction or exhaustion. Immunomodulator lenalidomide may improve CAR T-cell function. In this study, the effects of lenalidomide on CAR T-cell functions (cytotoxicity, cytokine secretion, and cell proliferation) were investigated. Two different CAR T cells (CD133-specific CAR and HER2-specific CAR) were prepared, and the corresponding target cells including human glioma cell line U251 CD133-OE that overexpress CD133 and human breast cancer cell line MDA-MB-453 were used for functional assay. We found that lenalidomide promoted the killing of U251 CD133-OE by CD133-CAR T cells, the cytokine secretion, and the proliferation of CD133-CAR T cells. Lenalidomide also enhanced the cytotoxicity against MDA-MB-453 and the cytokine secretion of HER2-CAR T cells but did not affect their proliferation significantly. Furthermore, lenalidomide may regulate the function of CAR T cells by inducing the degradation of transcription factors Ikaros and Aiolos.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689720920825
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2020466-8
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  • 7
    Online Resource
    Online Resource
    Measurement and Evaluation of the Alar Base in Unilateral Secondary Lip Nasal Deformities by Three-Dimensional Computed Tomography
    SAGE Publications ; 2013
    In:  The Cleft Palate-Craniofacial Journal Vol. 50, No. 6 ( 2013-11), p. 696-703
    Details
    In: The Cleft Palate-Craniofacial Journal, SAGE Publications, Vol. 50, No. 6 ( 2013-11), p. 696-703
    Abstract: This study aimed to analyze the asymmetry of the pyriform aperture and alar base in patients with unilateral secondary nasal deformities by three-dimensional computed tomography (3D-CT). Methods 3D-CT images of the subject group of 101 adult patients and of a control group of 65 normal adults were examined. Sixty-nine patients without alveolar bone grafting (ABG) were classified as Group A, and 32 patients with ABG were classified as Group B. Seven landmarks (INM, LPA, IPA, Gbase, Gsup, Glat, and Sbal) were measured for both the subject and control groups, and comparative analyses were done to assess the degree of asymmetry in the subject group. Results For over 95% of Group A and 80% to 85% of Group B, the index of LPA and IPA showed asymmetry or marked asymmetry. The index of Gbase, Glat, Gsup, and Sbal showed symmetry for around 50% of Group A and about 60% of Group B. In Group A, dorsal, lateral, and caudal translocation was found on the cleft side in LPA and IPA, while all soft landmarks showed dorsal translocation. In Group B, caudal translocation was found in both LPA and IPA, but only LPA appeared dorsal on the cleft side, while Glat showed dorsal and caudal translocation. Conclusion The results indicated that the degree of asymmetry of hard tissue landmarks far exceeded that of the soft tissue landmarks, and the degree of asymmetry of pyriform aperture was higher than expected for patients after ABG.
    Type of Medium: Online Resource
    ISSN: 1055-6656 , 1545-1569
    URL: Article
    DOI: 10.1597/11-144.1
    RVK:
    XA 36625
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2030056-6
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  • 8
    Online Resource
    Online Resource
    Correspondence regarding: ‘Evaluation and management of symptomatic isolated spontaneous celiac trunk dissection’ by Galastri et al.
    SAGE Publications ; 2016
    In:  Vascular Medicine Vol. 21, No. 6 ( 2016-12), p. 553-553
    Details
    In: Vascular Medicine, SAGE Publications, Vol. 21, No. 6 ( 2016-12), p. 553-553
    Type of Medium: Online Resource
    ISSN: 1358-863X , 1477-0377
    URL: Article
    DOI: 10.1177/1358863X16668042
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2027562-6
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