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  • Online Resource  (8)
  • SAGE Publications  (8)
  • 1
    In: Advances in Methods and Practices in Psychological Science, SAGE Publications, Vol. 1, No. 4 ( 2018-12), p. 443-490
    Abstract: We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance ( p 〈 .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion ( p 〈 .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely high-powered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small ( 〈 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.
    Type of Medium: Online Resource
    ISSN: 2515-2459 , 2515-2467
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2904847-3
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2009
    In:  Clinical Nursing Research Vol. 18, No. 4 ( 2009-11), p. 291-306
    In: Clinical Nursing Research, SAGE Publications, Vol. 18, No. 4 ( 2009-11), p. 291-306
    Abstract: Women frequently fail to recognize that coronary heart disease (CHD), not breast cancer, is the primary cause of female mortality. CHD mortality among U.S. mainland Puerto Rican (PR) women is second only to African American women. It is unknown what PR women understand about their risk, what factors they believe contribute to CHD, or whether they know the atypical symptoms often experienced by women. Most CHD studies exclude Hispanic women. Those that do often aggregate their results, making subgroup variations invisible. This study explored awareness of CHD symptoms, risks, and help-seeking behaviors among 12 PR women. Focus group methodology revealed that participants were unaware of their risk and had misconceptions about CHD symptoms and contributing factors. Barriers to early recognition and treatment included lack of knowledge, gender role conflict (caregiver vs. care recipient), and fears of falsely alarming family members or the embarrassment of feeling “dismissed” by health care providers.
    Type of Medium: Online Resource
    ISSN: 1054-7738 , 1552-3799
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2034682-7
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  American Journal of Alzheimer's Disease & Other Dementiasr Vol. 32, No. 1 ( 2017-02), p. 22-26
    In: American Journal of Alzheimer's Disease & Other Dementiasr, SAGE Publications, Vol. 32, No. 1 ( 2017-02), p. 22-26
    Abstract: Patients with amnestic mild cognitive impairment (aMCI) are at risk for developing Alzheimer’s disease. Due to their prominent memory impairment, structural magnetic resonance imaging (MRI) often focuses on the hippocampal region. However, recent positron-emission tomography data suggest that within a network of frontal and temporal changes, patients with aMCI show metabolic alterations in the precuneus, a key region for higher cognitive functions. Using high-resolution MRI and whole-brain cortical thickness analyses in 28 patients with aMCI and 25 healthy individuals, we wanted to investigate whether structural changes in the precuneus would be associated with cortical thickness reductions in frontal and temporal brain regions in patients with aMCI. In contrast to healthy people, patients with aMCI showed an association of cortical thinning in the precuneus with predominantly left-hemispheric thickness reductions in medial temporal and frontal cortices. Our data highlight structural neuronal network characteristics among patients with aMCI.
    Type of Medium: Online Resource
    ISSN: 1533-3175 , 1938-2731
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2235173-5
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  American Journal of Alzheimer's Disease & Other Dementiasr Vol. 33, No. 7 ( 2018-11), p. 458-462
    In: American Journal of Alzheimer's Disease & Other Dementiasr, SAGE Publications, Vol. 33, No. 7 ( 2018-11), p. 458-462
    Abstract: People with a first-degree family history of Alzheimer’s disease are at an increased risk of developing dementia. Subjective memory impairment among individuals with no measurable cognitive deficits may also indicate elevated dementia risk. It remains unclear whether nondemented people with a positive family history of Alzheimer’s disease are more likely to experience cognitive deficits and whether such an association reflects underlying neuropathology. We therefore investigated subjective memory impairment and hippocampal cortical thickness in 40 healthy older adults and 35 patients with amnestic mild cognitive impairment. We found greater subjective memory impairment and left hemispheric hippocampal cortical thinning associated with a first-degree family history of Alzheimer’s disease in healthy older adults. This suggests that subjective memory impairment could reflect preclinical stage neurodegeneration among individuals with the family history risk factor.
    Type of Medium: Online Resource
    ISSN: 1533-3175 , 1938-2731
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2235173-5
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  • 5
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 15 ( 2022-01), p. 175628642110704-
    Abstract: To support innovative trial designs in a regulatory setting for pediatric-onset multiple sclerosis (MS), the study aimed to perform a systematic literature review and meta-analysis of relapse rates with interferon β (IFN β), fingolimod, and natalizumab and thereby demonstrate potential benefits of Bayesian and non-inferiority designs in this population. Methods: We conducted a literature search in MEDLINE and EMBASE from inception until 17 June 2020 of all studies reporting annualized relapse rates (ARR) in IFN β-, fingolimod-, or natalizumab-treated patients with pediatric-onset relapsing–remitting MS. These interventions were chosen because the literature was mainly available for these treatments, and they are currently used for the treatment of pediatric MS. Two researchers independently extracted data and assessed study quality using the Cochrane Effective Practice and Organization of Care – Quality Assessment Tool. The meta-analysis estimates were obtained by Bayesian random effects model. Data were summarized as ARR point estimates and 95% credible intervals. Results: We found 19 articles, including 2 randomized controlled trials. The baseline ARR reported was between 1.4 and 3.7. The meta-analysis-based ARR was significantly higher in IFN β-treated patients (0.69, 95% credible interval: 0.51–0.91) versus fingolimod (0.11, 0.04–0.27) and natalizumab (0.17, 0.09–0.31). Based on the meta-analysis results, an appropriate non-inferiority margin versus fingolimod could be in the range of 2.29–2.67 and for natalizumab 1.72–2.29 on the ARR ratio scale. A Bayesian design, which uses historical information for a fingolimod or natalizumab control arm, could reduce the sample size of a new trial by 18 or 14 patients, respectively. Conclusion: This meta-analysis provides evidence that relapse rates are considerably higher with IFNs versus fingolimod or natalizumab. The results support the use of innovative Bayesian or non-inferiority designs to avoid exposing patients to less effective comparators in trials and bringing new medications to patients more efficiently.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2442245-9
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2016
    In:  American Journal of Alzheimer's Disease & Other Dementiasr Vol. 31, No. 5 ( 2016-08), p. 450-456
    In: American Journal of Alzheimer's Disease & Other Dementiasr, SAGE Publications, Vol. 31, No. 5 ( 2016-08), p. 450-456
    Abstract: A first-degree family history of Alzheimer’s disease reflects genetic risks for the neurodegenerative disorder. Recent imaging data suggest localized effects of genetic risks on brain structure in healthy people. It is unknown whether this association can also be found in patients who already have dementia. Our aim was to investigate whether family history risk modulates regional medial temporal lobe cortical thickness in patients with Alzheimer’s disease. We performed high-resolution magnetic resonance imaging and cortical unfolding data analysis on 54 patients and 53 nondemented individuals. A first-degree family history of Alzheimer’s disease was associated with left hemispheric cortical thinning in the subiculum among patients and controls. The contribution of Alzheimer’s disease family history to regional brain anatomy changes independent of cognitive impairment may reflect genetic risks that modulate onset and clinical course of the disease.
    Type of Medium: Online Resource
    ISSN: 1533-3175 , 1938-2731
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2235173-5
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Phi Delta Kappan Vol. 100, No. 8 ( 2019-05), p. 62-66
    In: Phi Delta Kappan, SAGE Publications, Vol. 100, No. 8 ( 2019-05), p. 62-66
    Abstract: Collaborative learning requires a lot of talk. Although not all student talk may be related to the task at hand, some off-task talk is actually productive, as it enables students to negotiate how they will work together, gain attention of fellow group members, and draw others into joining the work. Emma C. Gargroetzi, Rosa D. Chavez, Jen Munson, Jennifer M. Langer-Osuna, and Kimiko E. Lange observed 4th-grade students working in groups on math exercises and saw multiple seemingly off-task conversations that, in fact, ended up bringing the group together. For example, students who were excluded used off-task talk to get others in the group to pay attention to them. Groups also used off-task talk to ensure that everyone in the group had a role in the solution. The authors offer guidelines for determining when to intervene when students engage in off-task talk.
    Type of Medium: Online Resource
    ISSN: 0031-7217 , 1940-6487
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2066884-3
    detail.hit.zdb_id: 3093059-5
    detail.hit.zdb_id: 281485-7
    SSG: 5,3
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Clinical Medicine Insights: Endocrinology and Diabetes Vol. 11 ( 2018-01-01), p. 117955141774894-
    In: Clinical Medicine Insights: Endocrinology and Diabetes, SAGE Publications, Vol. 11 ( 2018-01-01), p. 117955141774894-
    Abstract: The relationship between genetic risk variants associated with glucose homeostasis and type 2 diabetes risk has yet to be fully explored in African American populations. We pooled data from 4 prospective studies including 4622 African Americans to assess whether β-cell dysfunction (BCD) and/or insulin resistance (IR) genetic variants were associated with increased type 2 diabetes risk. The BCD genetic risk score (GRS) and combined BCD/IR GRS were significantly associated with increased type 2 diabetes risk. In cardiometabolic-stratified models, the BCD and IR GRS were associated with increased type 2 diabetes risk among 5 cardiometabolic strata: 3 clinically healthy strata and 2 clinically unhealthy strata. Genetic risk scores related to BCD and IR were associated with increased risk of type 2 diabetes in African Americans. Notably, the GRSs were significant predictors of type 2 diabetes among individuals in clinically normal ranges of cardiometabolic traits.
    Type of Medium: Online Resource
    ISSN: 1179-5514 , 1179-5514
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2628990-8
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