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  • 11
    Online Resource
    Online Resource
    Evaluation on Short-Term Therapeutic Effect of 2 Porphyrin Photosensitizer-Mediated Photodynamic Therapy for Esophageal Cancer
    SAGE Publications ; 2019
    In:  Technology in Cancer Research & Treatment Vol. 18 ( 2019-01-01), p. 153303381983198-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 18 ( 2019-01-01), p. 153303381983198-
    Abstract: To analyze and study the short-term therapeutic effects and main adverse effects of 2 Porphyrin photosensitizer-mediated photodynamic therapy for esophageal cancer. Methods: We apply the hematoporphyrin derivative and hematoporphyrin injection produced by different manufacturers at different periods as photosensitizers in therapy of 79 esophageal cancer cases, with the administration dosage of 5 mg/kg and intravenous drip 24 hours before irradiation. We apply the gold vapor laser and semiconductor laser, respectively, as treatment light source, with the power density of 100 to 300 mW/cm 2 and energy density of 100 to 300 J/cm 2 . After treatment for 1 to 4 sessions, we evaluate the short-term therapeutic effects as complete response, partial response, minor response, or no change, and then make comparative study on therapeutic effects and adverse effects. Results: There were 47 patients in hematoporphyrin derivative group, including 3 (6.4%) patients with complete response, 31 (66.0%) patients with partial response, 10 (21.3%) patients with minor response, and 3 (6.4%) patients with no change. The dysphagia score was reduced from 2.53 (1.16) before treatment to 1.32 (1.20; P 〈 .01) after treatment. There were 32 patients in the hematoporphyrin injection group, including 3 (9.4%) patients with complete response, 19 (59.4%) patients with partial response, 6 (18.8%) patients with minor response, and 4 (12.5%) patients with no change. The dysphagia score was reduced from 2.41 (1.13) before treatment to 1.18 (0.99; P 〈 .01) after treatment. The dysphagia scores of 2 groups after treatment were significantly reduced compared to those before treatment. Both groups did not display serious adverse effect. Conclusions: Two porphyrin photosensitizers in treatment of esophageal cancer at different clinical stages all had good effect with similar therapeutic effect, mild adverse effect, and good tolerance, which implies it is a preferable palliative therapy means.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033819831989
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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    detail.hit.zdb_id: 2220436-2
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  • 12
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    Online Resource
    Prediction of fatigue crack propagation based on dynamic Bayesian network
    SAGE Publications ; 2022
    In:  Advances in Mechanical Engineering Vol. 14, No. 11 ( 2022-11), p. 168781322211364-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 14, No. 11 ( 2022-11), p. 168781322211364-
    Abstract: To address the problem of low prediction accuracy in the current research on fatigue crack propagation prediction, a prediction method of fatigue crack propagation based on a dynamic Bayesian network is proposed in this paper. The Paris Law of crack propagation and the extended finite element method (XFEM) are combined to establish the state equation of crack propagation. The uncertain factors of crack propagation are analyzed, and the prediction model of fatigue crack propagation based on the dynamic Bayesian network is constructed. A Bayesian inference algorithm based on the combination of Gaussian particle filter and firefly algorithm is proposed. The fatigue experiment of the specimen with the pre-cracks is carried out to test the correlation between the fatigue load cycles and the crack propagation depth. The experimental results show that the crack propagation prediction method proposed in this paper can effectively improve the prediction accuracy of crack propagation depth.
    Type of Medium: Online Resource
    ISSN: 1687-8132 , 1687-8140
    URL: Article
    DOI: 10.1177/16878132221136413
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2501620-9
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  • 13
    Online Resource
    Online Resource
    Distributed robust output feedback control of uncertain fractional-order reaction-diffusion systems
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering Vol. 237, No. 1 ( 2023-01), p. 86-101
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering, SAGE Publications, Vol. 237, No. 1 ( 2023-01), p. 86-101
    Abstract: This article focuses on the problem of distributed robust stabilization for a class of uncertain fractional-order reaction–diffusion systems (FRDS) by using two distributed output feedback control strategies: pointwise control based on collocated pointwise measurements and piecewise control based on collocated piecewise measurements. First, the corresponding distributed robust feedback controllers are designed based on the two measurement methods. Then, based on the Lyapunov direct method, Mittag-Leffler (M-L) function, and linear matrix inequality technique (LMI), sufficient conditions for the Mittag-Leffler stability of the closed-loop system are obtained in terms of linear matrix inequalities, respectively. Finally, numerical studies are given to verify the effectiveness of the robust distributed controllers designed in this article.
    Type of Medium: Online Resource
    ISSN: 0959-6518 , 2041-3041
    URL: Article
    DOI: 10.1177/09596518221118125
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024903-2
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  • 14
    Online Resource
    Online Resource
    Polarization-Based Diffuse Reflectance Imaging for Noninvasive Measurement of Glucose
    SAGE Publications ; 2007
    In:  Journal of Diabetes Science and Technology Vol. 1, No. 6 ( 2007-11), p. 873-878
    Details
    In: Journal of Diabetes Science and Technology, SAGE Publications, Vol. 1, No. 6 ( 2007-11), p. 873-878
    Abstract: The ability to measure glucose concentration through noninvasive approaches would impact the treatment of diabetes significantly. Polarization-based optical approaches have received considerable interest because of their potential medical applications. Glucose, a chiral molecule, has the ability to rotate the plane of linearly polarized light, commonly referred to as optical activity, as well as changing the refractive index of the media, which therefore affects the overall scattering coefficient in a given media. The magnitude of each effect is related to the concentration of glucose. Although most previous studies have reported on the use of polarimetry in the aqueous humor of the eye because of its nonscattering nature, one would also expect that glucose concentration could be measured in more turbid media such as tissue through a similar approach. This study investigated how each of these effects is correlated to glucose concentration in a physiological range for highly scattering biological media. Methods: A custom-designed imaging polarimeter was used to image highly scattering Intralipid-based media containing different concentrations of glucose. Model formation and glucose prediction were performed through the use of partial least squares (PLS) regression. Further insight into the differences between polarization-based image measurements and encoding of glucose information was provided through the use of principal component analysis (PCA). Results: When coupled with PLS regression, in vitro polarization measurements yielded highly correlated glucose predictions in both calibration and independent validation, 0.999 and 0.998, respectively. Through the use of PCA, it appears that the majority of the image-based signal yielding the most significant glucose information is attributable to changes in the overall scattering coefficient due to glucose concentration and, to a lesser degree, effects of optical activity. Conclusions: This study showed how polarimetric-based imaging coupled with PLS regression can be used to quantify glucose concentration in highly scattering media. Such methods may potentially be able to extend the use of noninvasive in vivo polarimetric measurements, normally acquired in the anterior chamber of the eye, to other preferred sensing sites such as the skin.
    Type of Medium: Online Resource
    ISSN: 1932-2968 , 1932-2968
    URL: Article
    DOI: 10.1177/193229680700100611
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2467312-2
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  • 15
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    Online Resource
    Disseminated visceral Kaposi’s sarcoma after allogeneic hematopoietic stem cell transplantation: a case report
    SAGE Publications ; 2023
    In:  Journal of International Medical Research Vol. 51, No. 5 ( 2023-05), p. 030006052311728-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 51, No. 5 ( 2023-05), p. 030006052311728-
    Abstract: Cases of disseminated visceral Kaposi’s sarcoma (KS) after allogenic hematopoietic stem cell transplantation (HSCT) are very rare worldwide, and disseminated visceral KS is often rapidly progressive and life-threatening, especially in paediatric patients. Here, the case of a 6-year-old female patient with disseminated visceral KS after allogeneic HSCT for treating severe aplastic anaemia is presented. The authors encountered difficulties in making the diagnosis due to lack of experience, but the diagnosis was achieved relatively quickly and accurately using metagenomic next-generation sequencing. After tapering and withdrawal of immunosuppressant drugs, the patient's condition was controlled. In conclusion, although HSCT-related KS is very rare, it should be considered during differential diagnosis.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605231172871
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2082422-1
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  • 16
    Online Resource
    Online Resource
    Strategies to Improve the Migration of Mesenchymal Stromal Cells in Cell Therapy
    SAGE Publications ; 2017
    In:  Translational Neuroscience and Clinics Vol. 3, No. 3 ( 2017-09), p. 159-175
    Details
    In: Translational Neuroscience and Clinics, SAGE Publications, Vol. 3, No. 3 ( 2017-09), p. 159-175
    Abstract: Mesenchymal stromal/stem cells (MSCs) are multipotent cells under consideration as a potential new therapy for a variety of inflammatory diseases including certain neurological disorders. It is generally thought that the efficacy of cell therapy in attenuating damage after ischemia, inflammation, or injury depends on the quantity of transplanted cells recruited to the target tissue. However, only a small number of systematically infused MSCs can effectively migrate to target sites, which significantly decreases the efficacy of exogenous cell-based therapy. In this review, we discuss specific factors influencing MSC migration, and summarize current strategies that effectively promote the motility of MSCs. In addition, we describe several protocols to improve the migration of stromal cells into the nervous system and, therefore, enhance the efficiency of engraftment as means of treating neurological disorders.
    Type of Medium: Online Resource
    ISSN: 2096-0441
    URL: Article
    DOI: 10.18679/CN11-6030_R.2017.025
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 17
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    Online Resource
    Hematological features and risk factors of hospitalized COVID-19 patients: A retrospective analysis
    SAGE Publications ; 2022
    In:  European Journal of Inflammation Vol. 20 ( 2022-01), p. 1721727X2210929-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 20 ( 2022-01), p. 1721727X2210929-
    Abstract: Coronavirus disease 2019 (COVID-19) became pandemic in 2020 and recently, mutated coronaviruses have emerged in many countries. The aim of this study was to identify the clinical characteristics and risk factors for critical illness in hospitalized COVID-19 patients in Zhengzhou for clinical prevention and management. Materials and methods: A total of 70 patients hospitalized with COVID-19 were enrolled between 21 January and 29 February 2020, in Zhengzhou, China. Clinical characteristics, hematological findings, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and inflammatory index on admission were obtained from medical records, COVID-19 patients with different outcomes were compared. Results: The median age was 55 years. Forty-three (61.0%) patients were classified as having severe or critical cases. Eighteen (25.7%) patients died in hospital and the remaining 52 were discharged. Patients who died tend to be old with expectoration and chronic obstructive pulmonary disease. Compared to survivor, non-survivor had significantly higher numbers of leucocytes and neutrophils, NLR, aspartate aminotransferase (AST), γ-glutamyl transpeptidase, total bilirubin, direct bilirubin, lactate dehydrogenase (LDH), prothrombin time, D-dimer, C-reactive protein, and decreased platelets, lymphocytes, uric acid, and albumin (ALB). Logistic regression analysis identified leucocytes, platelets, PLR, NLR, AST, and ALB as independent predictive factors for poor outcomes. The area under curve of the combination of leucocytes, PLR, NLR, and AST was 0.87, with a sensitivity of 0.83 and specificity of 0.81. Conclusion: Our results identified risk factors among COVID-19 patients for in-hospital mortality. Leucocytes, PLR, NLR, and AST could have important reference value for predicting prognosis, especially in low-resource countries.
    Type of Medium: Online Resource
    ISSN: 1721-727X , 2058-7392
    URL: Article
    DOI: 10.1177/1721727X221092909
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2584683-8
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  • 18
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    Dynamic Between-Leg Differences While Walking in Anterior Cruciate Ligament–Deficient Patients With and Without Medial Meniscal Posterior Horn Tears
    SAGE Publications ; 2020
    In:  Orthopaedic Journal of Sports Medicine Vol. 8, No. 5 ( 2020-05-01), p. 232596712091905-
    Details
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 8, No. 5 ( 2020-05-01), p. 232596712091905-
    Abstract: Patients with anterior cruciate ligament–deficient (ACLD) knees with medial meniscal posterior horn tears (MMPHTs) have been reported to demonstrate a combined stiffening and pivot-shift gait pattern compared with healthy controls. Movement asymmetries are implicated in the development and progression of osteoarthritis. Purpose: To investigate the knee kinematics and kinetic asymmetries in ACLD patients with (ACLD + MMPHT group) and without (ACLD group) MMPHTs while walking on level ground. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 15 patients with isolated unilateral ACL ruptures, 10 with unilateral ACL ruptures and MMPHTs, and 22 healthy controls underwent gait testing between January 2014 and December 2016. Between-leg differences (BLDs) in knee kinematics and kinetics were compared among participants in all groups. Results: The ACLD + MMPHT group demonstrated significantly greater BLDs in knee moments in the sagittal plane during the loading response phase than the ACLD and control groups. Compared with the control group, the ACLD and ACLD + MMPHT groups demonstrated significantly greater BLDs in knee angles in the sagittal plane during the midstance and terminal stance phases. Compared with the control group, significantly greater BLDs in knee rotation moments were found throughout the stance phase in both the ACLD and the ACLD + MMPHT groups. BLDs in lateral ground-reaction forces (GRFs) in the ACLD + MMPHT and ACLD groups were both significantly greater than the control group during the loading response phase. BLDs in anterior GRFs in the ACLD + MMPHT and ACLD groups were both significantly greater than the control group during the loading response phase. Only the ACLD + MMPHT group demonstrated greater BLDs in vertical GRFs than the control group during the loading response phase, while no significant differences were observed between the ACLD and control groups. Conclusion: The ACLD + MMPHT group demonstrated significantly more knee flexion moment asymmetries than the ACLD and control groups during the loading response phase. Both the ACLD + MMPHT and the ACLD groups demonstrated significant knee angle and moment asymmetries in the sagittal plane during the terminal stance phase than the control group. Both the ACLD + MMPHT and the ACLD groups demonstrated knee rotation moment asymmetries during the midstance and terminal stance phases compared with the control group. A rehabilitation program for ACLD patients both with and without MMPHTs should take into consideration these asymmetric gait patterns.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    URL: Article
    DOI: 10.1177/2325967120919058
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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  • 19
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    Online Resource
    Reliability of a Novel Automatic Knee Arthrometer for Measuring Knee Laxity After Anterior Cruciate Ligament Ruptures
    SAGE Publications ; 2022
    In:  Orthopaedic Journal of Sports Medicine Vol. 10, No. 2 ( 2022-02-01), p. 232596712110513-
    Details
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 10, No. 2 ( 2022-02-01), p. 232596712110513-
    Abstract: The accuracy of existing devices for measuring knee laxity is adversely affected by examiner reliability. Purpose: To compare the accuracy of a novel automatic knee arthrometer (AKA) to that of the KT-2000 arthrometer for measuring knee laxity after anterior cruciate ligament (ACL) ruptures. Study Design: Cohort study; Level of evidence, 2. Methods: We measured anterior displacement and the anterior displacement difference (ADD) at 134 N of anterior force in 221 healthy volunteers and 200 patients with ACL ruptures. All trials were performed by the same 2 examiners. We first analyzed the effects of examiner, side assessed, and device type using the intraclass correlation coefficient (ICC), t test, and F test. We then used the receiver operating characteristic curve to compare the diagnostic value of the measurements between devices. Results: In repeated measurements for a single healthy volunteer, there were no differences in the variance of the measurements between sides according to the AKA (standard deviation of right vs left knee for examiner A: 0.43 vs 0.58 mm, respectively [ P = .39]; for examiner B: 0.49 vs 0.77 mm, respectively [ P = .81] ), while the KT-2000 measurements showed differences (standard deviation of right vs left knee for examiner A: 1.47 vs 0.80 mm, respectively [ P = .02]; for examiner B: 1.78 vs 0.91 mm, respectively [ P = .01] ). The ADD assessed by the AKA was not significantly different between examiners A and B (0.50 vs 0.75 mm, respectively; P = .27; ICC = 0.83), but the KT-2000 showed a difference (1.07 vs 2.01 mm, respectively; P = .01; ICC = 0.55). The ADD of 20 healthy volunteers assessed by the AKA was less than that by the KT-2000 (0.98 vs 1.41 mm, respectively; P = .04). When comparing the diagnostic value of the 2 devices in the sample of 200 patients with ACL ruptures and 200 healthy controls, the area under the receiver operating characteristic curve for the AKA was larger than that for the KT-2000 (0.93 vs 0.87, respectively; P ≤ .01), and the threshold values were 1.75 and 2.73 mm, respectively. Conclusion: The AKA can be used to determine the degree of knee laxity in ACL injuries and to provide indications for treatment.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    URL: Article
    DOI: 10.1177/23259671211051301
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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  • 20
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    Optimal scheduling for aerial recovery of multiple unmanned aerial vehicles using genetic algorithm
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 233, No. 14 ( 2019-11), p. 5347-5359
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 233, No. 14 ( 2019-11), p. 5347-5359
    Abstract: The ability to deploy multiple unmanned aerial vehicles expands their application range, but aerial recovery of unmanned aerial vehicles presents many unique challenges owing to the number of unmanned aerial vehicles and the limited recovery time. In this paper, scheduling the aerial recovery of multiple unmanned aerial vehicles by one mothership is posed as a combinatorial optimization problem. A mathematical model with recovery time windows of the unmanned aerial vehicles is developed to formulate this problem. Furthermore, a genetic algorithm is proposed for finding the optimal recovery sequence. The algorithm adopts the path representation of chromosomes to simplify the encoding process and the genetic operations. It also resolves decoding difficulties by iteration, and thus can efficiently generate a recovery timetable for the unmanned aerial vehicles. Simulation results in stochastic scenarios validate the performance of the proposed algorithm compared with the random search algorithm and the greedy algorithm.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410019842487
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2032759-6
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