In:
Chemical Communications, Royal Society of Chemistry (RSC), Vol. 58, No. 47 ( 2022), p. 6765-6768
Abstract:
A new type of organocatalyzed 1,3-thiosulfonylation has been developed to straightforwardly access highly functionalized vinyl sulfones, which features mild conditions, atom- and step-economy, practicability, conciseness, and environmental friendliness. Moreover, these valuable products can be transformed to vinyl sulfides via a base-promoted isomerization. The versatile route can efficiently and rapidly introduce SCD 3 groups with excellent levels of deuterium content ( 〉 99% D) by utilizing our newly developed SCD 3 reagents. Gram-scale operations and further transformations are smoothly carried out, providing promising applications for drug discovery.
Type of Medium:
Online Resource
ISSN:
1359-7345
,
1364-548X
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
1472881-3
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