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  • 1
    In: Viruses, MDPI AG, Vol. 13, No. 8 ( 2021-08-13), p. 1605-
    Abstract: While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE—detected in the Yoruba population of Nigeria—conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the “emerging” nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz’s critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2516098-9
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  • 2
    In: Sustainability, MDPI AG, Vol. 14, No. 10 ( 2022-05-13), p. 5948-
    Abstract: The impacts of conflicting aerodynamic forces and side drifting forces are the primary unstable elements in automobiles. The action of an unstable environment in automobile vehicles increases the chance of an accident occurring. As a result, much study is required to determine how opposing aerodynamic forces and side drifting force affects function, as well as how to deal with them for safe and smooth navigation. In this work, an intercity bus is chosen as a main object, and computational fluid dynamics (CFD) analysis is used to estimate aerodynamic forces on the bus in all major directions. Experimentation is also carried out for validation reasons. CFD findings for a scaled base model and a dimple-loaded model based on experimental results from a subsonic wind tunnel are demonstrated to be correct. The drag forces generated by CFD simulations on test models are carefully compared to the experimental drag findings of same-dimensioned models. The error percentages between the results of these two methods are acquired and the percentages are determined to be within an acceptable range of significant limitations. Following these validations, CATIA is used to create a total of nine distinct models, the first of which is a standard intercity bus, whereas the other eight models are fitted with drag reduction techniques such as dimples, riblets, and fins on the surface of their upper cumulus side. A sophisticated computational tool, ANSYS Fluent 17.2, is used to estimate the comparative assessments of the predictions of aerodynamic force fluctuations on bus models. Finally, dimples on the top and side surfaces of the bus model (DESIGN–I) are proposed as a more efficient model than other models because dimples are a vital component that may lower pressure drag on the bus by 18% in the main flow direction and up to 43% in the sideslip direction. Furthermore, by minimizing the different aerodynamic force sources without impacting the preparatory needs, the proposed model may provide comfortable travel. The real-time bus is created, and the finalized drag reduction is applied to the optimized places over the whole bus model. In addition, five distinct size-based bus models are developed and studied in terms of aerodynamic forces, necessary energy to resist aerodynamic drag, required forward force for successful movement, instantaneous demand for particular power, and fuel consumption rate. Finally, the formation of aeroacoustic noise owing to turbulence is estimated using sophisticated computer simulation. Last, for real-time applications, multi-parametric studies based on appropriate intercity buses are established.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518383-7
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  • 3
    In: Processes, MDPI AG, Vol. 11, No. 9 ( 2023-09-02), p. 2625-
    Abstract: This work primarily investigates the performance and structural integrity of the Wells turbines for power production in coastal locations and their associated unmanned vehicles. An innovative design procedure is imposed on the design stage of the Wells turbine and thus so seven different models are generated. In the first comprehensive investigation, these seven models underwent computational hydrodynamic analysis using ANSYS Fluent 17.2 for various coastal working environments such as hydro-fluid speeds of 0.34 m/s, 1.54 m/s, 12 m/s, and 23 m/s. After this primary investigation, the best-performing Wells turbine model has been imposed as the second comprehensive computational investigation for three unique design profiles. The imposed unique design profile is capable of enhancing the hydro-power by 15.19%. Two detailed, comprehensive investigations suggest the best Wells turbine for coastal location-based applications. Since the working environments are complicated, additional advanced computational investigations are also implemented on the best Wells turbine. The structural withstanding capability of this best Wells turbine model has been tested through coupled computational hydro-structural analysis for various lightweight materials. This best Wells turbine also enforces the vibrational failure factors such as modal and harmonic vibrational analyses. Finally, advanced and validated coupled engineering approaches are proposed as good methodology for coastal location-based hydropower applications.
    Type of Medium: Online Resource
    ISSN: 2227-9717
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2720994-5
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  • 4
    In: Aerospace, MDPI AG, Vol. 9, No. 11 ( 2022-10-26), p. 652-
    Abstract: The conceptual design, component selection, and deployment experiments of an unmanned amphibious system (US) with a unique Becker in vertical stabilizer based on hydrodynamic research are included in this work. The use of USs is currently expanding significantly, and they are used for fish detection, oceanographic mapping, mining detection, monitoring marine life, and navy purposes. With a maximum forward speed of 30 m/s, the US’s hull is largely built with criteria for identifying and researching marine species. The significant lifetime decline of ocean species drives the deployment of unmanned vehicles for species monitoring from the water’s surface to 300 m below the surface. In addition, the medical team can help the species with health problems using this planned US because they have been identified. The conceptual design and estimated analytical equations encompass the fuselage, Becker rudder, propeller, and other sub-components. The locations of sensors, primarily used to locate mobile marine life, are also considered. A Becker rudder has been imposed to make sharp turns when the US is submerged in water. An advanced hydro propeller produces the propulsion with a 20 cm base diameter. Additionally, a piezoelectric patching-based energy extracting approach is used to the hydro-outside propeller’s surface. As a result, the electrical power generation for different lightweight materials is computed for the performance of US manoeuvrings. With the help of CATIA modelling of the intended USs and ANSYS Fluent hydrodynamic simulations, appropriate high-speed configurations are selected. Various stages of its mission profile, including the US in steady-level flight, the US in climb, and the US over the ocean surface, are subjected to computational simulations. Using an advanced computational technique and previously established experimental correlations, the reliability of these various computational solutions is examined and kept at an appropriate level. This US is highly suggested for marine-based real-time applications due to its acceptable output.
    Type of Medium: Online Resource
    ISSN: 2226-4310
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2756091-0
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  • 5
    In: Symmetry, MDPI AG, Vol. 14, No. 10 ( 2022-09-29), p. 2035-
    Abstract: In recent years, the use of unmanned aerial vehicles (UAVs) has increased significantly. Asymmetrical factors, or frictional studies on the disc brake of UAVs, are one of the safety considerations taken into consideration during the design process because UAVs and their components have been built with the best safety in mind. This study focuses on choosing the optimal material for a UAV’s disc brake by using transient structural and thermal models. In order to compare the asymmetry-based frictional force produced by the two ways; the processes used in the transient simulation are validated using pin-on-disc (POD) testing. The foundation for this validation investigation is a metal matrix composite made of an aluminum alloy, and the basis tool is an ASTM G99-based computational test specimen. Steel-EN24 and carbon ceramic matrix composites testing are expanded using the same POD tests. A range of 3 percent to 8 percent error rates is found. As a result, the calculation techniques are applied to the UAV’s disc brake after they have proven to be trustworthy. This fixed-wing UAV’s extensions have a 5 kg payload capacity. The weight, avionics components, tire dimensions, and disc brake dimensions of the other UAV design parts are calculated using analytical formulas. The final designs are made using CATIA as a result. The grid convergence experiment is organized using a traditional finite element analysis tool. Finally, at its maximum rotational speed, a UAV’s disc brake is put through asymmetrical friction testing based on structural and thermal consequences. The correct materials for critical applications, such as carbon fiber-woven-wet-based reinforced polymer and Kevlar unidirectional-49-based reinforced polymer composites for changing rotating speeds, have now been made possible by fixed-wing UAVs.
    Type of Medium: Online Resource
    ISSN: 2073-8994
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518382-5
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  • 6
    Online Resource
    Online Resource
    MDPI AG ; 2021
    In:  Pathogens Vol. 10, No. 4 ( 2021-04-19), p. 490-
    In: Pathogens, MDPI AG, Vol. 10, No. 4 ( 2021-04-19), p. 490-
    Abstract: Biofilms are bacterial communities encased in a rigid yet dynamic extracellular matrix. The sociobiology of bacterial communities within a biofilm is astonishing, with environmental factors playing a crucial role in determining the switch from planktonic to a sessile form of life. The mechanism of biofilm biogenesis is an intriguingly complex phenomenon governed by the tight regulation of expression of various biofilm-matrix components. One of the major constituents of the biofilm matrix is proteinaceous polymers called amyloids. Since the discovery, the significance of biofilm-associated amyloids in adhesion, aggregation, protection, and infection development has been much appreciated. The amyloid expression and assembly is regulated spatio-temporarily within the bacterial cells to perform a diverse function. This review provides a comprehensive account of the genetic regulation associated with the expression of amyloids in bacteria. The stringent control ensures optimal utilization of amyloid scaffold during biofilm biogenesis. We conclude the review by summarizing environmental factors influencing the expression and regulation of amyloids.
    Type of Medium: Online Resource
    ISSN: 2076-0817
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2695572-6
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  • 7
    In: Journal of Marine Science and Engineering, MDPI AG, Vol. 10, No. 11 ( 2022-10-22), p. 1568-
    Abstract: Recent large-scale operations, including frequent maritime transportation and unauthorised as well as unlawful collisions of drainage wastes, have polluted the ocean’s ecology. Due to the ocean’s unsuitable ecology, the entire globe may experience drastic aberrant conditions, which will force illness onto all living things. Therefore, an advanced system is very necessary to remove the undesired waste from the ocean’s surface and interior. Through the use of progressive unmanned amphibious vehicles (UAV), this study provides a dynamic operational mode-based solution to damage removal. In order to successfully handle the heavy payloads of ravage collections when the UAV reveals centre of gravity concerns, a highly manoeuvrable-based design inspired by nature has been imposed. The ideal creatures to serve as the inspiration for this piece are tropical birds, which have a long tail for navigating tricky situations. The design initialization was carried out by focusing on the outer body of tropical birds. Following this, special calculations were conducted and the full design parameters of the UAV were established. This study proposes a unique mathematical formulation for the development of primary and secondary design parameters of an UAV. The proposed mission profile of this application is computationally tested with the aid of sophisticated computational methodologies after the modelling of this UAV. The computational methods that are required are one-way coupling-based hydro-structural interaction assessments and computational hydrodynamic analyses. Computing is used to determine the aerodynamic and hydrodynamic forces over the UAV, the lightweight materials to withstand high fluid dynamic loads, and the buoyancy forces to complete the UAV components. These computational methods have been used to produce a flexible and fine-tuned UAV design for targeted real-time applications.
    Type of Medium: Online Resource
    ISSN: 2077-1312
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2738390-8
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