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  • 1
    Online Resource
    Online Resource
    Study on the Mechanism of Radix Astragali against Renal Aging Based on Network Pharmacology
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-12-13), p. 1-13
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-12-13), p. 1-13
    Abstract: Radix Astragali is widely used in the traditional Chinese medicine with the effect of antiaging. The purpose of this study is to explore the main active ingredients and targets of Radix Astragali against renal aging by network pharmacology and further to verify the mechanism of the main active ingredients in vitro. TCMSP, ETCM, and TCMID databases were used to screen active ingredients of Radix Astragali. Targets of active ingredients were predicted using BATMAN-TCM and cross validated using kidney aging-related genes obtained from GeneCards and NCBI database. Pathways enrichment and protein-protein interaction (PPI) analysis were performed on core targets. Additionally, a pharmacological network was constructed based on the active ingredients-targets-pathways. HK-2 cell was treated with D-galactose to generate a cell model of senescence. CCK-8 and β-galactosidase were used to detect the effect of Radix Astragali active components on cell proliferation and aging. ELISA was used to detect the expression of senescence-associated secreted protein (TGF-β and IL-6) in the cell culture supernatant. Western blot was used to detect the expression of key proteins in the SIRT1/ p 53 pathway. Five active ingredients (Astragaloside I, II, III, IV and choline) were identified from Radix Astragali, and all these active ingredients target a total of 128 genes. Enrichment analysis showed these genes were implicated in 153 KEGG pathways, including the p 53 , FoxO, and AMPK pathway. 117 proteins and 572 interactions were found in PPI network. TP53 and SIRT1 were two hub genes in PPI network, which interacted with each other. The pharmacological network showed that the five main active ingredients target on some coincident genes, including TP53 and SIRT1. These targeted genes were involved in the p53, FoxO, and AMPK pathway. Proliferation of HK-2 cells was increased by Astragaloside IV treatment compared with that of the D-Gal treatment group. However, the proliferation of the SA-β-gal positive cells were inhibited. The expression of TGF-β and IL-6 in the D-Gal group was higher than that in the normal group, and the treatment of Astragaloside IV could significantly reduce the expression of TGF-β and IL-6. The expression of SIRT1 in the Astragaloside IV group was higher than that in the D-Gal group. However, the expression of p 53 and p 21 was less in the Astragaloside IV group than that in the D-Gal group. This study suggested that Astragaloside IV is an important active ingredient of Radix Astragali in the treatment of kidney aging via the SITR1- p 53 pathway.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/6987677
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 2
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    Online Resource
    The Causality Research between Syndrome Elements by Attribute Topology
    Hindawi Limited ; 2018
    In:  Computational and Mathematical Methods in Medicine Vol. 2018 ( 2018-07-02), p. 1-12
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2018 ( 2018-07-02), p. 1-12
    Abstract: Background. The traditional Chinese medicine (TCM) is an empirical medical system and has its own diagnosis and treatment method. The syndrome elements are atoms to modern TCM diagnosis proposed by Professor Zhu Wenfeng. Researching and analyzing the syndrome element system is one of the active issues for TCM research. At present, most related researches focus on the correlativity and hierarchical relationship of the diseases and symptoms, but the causality researches between syndrome elements themselves have not been reported so far. Methods. To explore the causality between syndrome elements, a method named causality by attribute topology (CAT) is proposed. Based on the subordinate relations in attribute topology, the inference method analyzes and reasons the dependency relationship between the sets of objects which contain attributes. Through the removal of attributes in the attribute topology, the formal context is updated constantly. Thus, the causal relationship among the attributes is deduced. In this method, 500 records are mathematically transferred to a binary context for syndrome element analysis. Through the analysis and verification of the potential causal relationship between the syndrome elements, knowledge discovery of the diagnostic data of traditional Chinese medicine based on attribute topology structure diagram is conducted. Results. This paper has verified the causal transformation between these syndrome elements. The experimental results between the female group data and the male group data show that different genders have different characteristics and relations of syndrome elements. The experimental results are basically consistent with the traditional Chinese medicine theory. Conclusion. The experiment shows that causality by attribute topology (CAT) is feasible to describe the causality between TCM syndrome elements. Further research on possible knowledge discovery in TCM diagnostic data should be conducted through the analysis of the potential causal relationship between TCM diagnostic data and each syndrome element.
    Type of Medium: Online Resource
    ISSN: 1748-670X , 1748-6718
    URL: Article
    DOI: 10.1155/2018/9707581
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2256917-0
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  • 3
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    Online Resource
    Multielement Imaging Reveals the Diagenetic Features and Varied Water Redox Conditions of a Lacustrine Dolomite Nodule
    Hindawi Limited ; 2022
    In:  Geofluids Vol. 2022 ( 2022-1-10), p. 1-20
    Details
    In: Geofluids, Hindawi Limited, Vol. 2022 ( 2022-1-10), p. 1-20
    Abstract: The genesis of dolostone has long been puzzling for more than two centuries. Although much work has been done on investigating the process of dolomitization, little emphasis has been put on examining the diagenetic water redox condition with the wealthy geochemical information preserved in primary dolomite, which is believed to archive the aqueous environment as well as biotic and/or abiotic effects during formation. In situ interpretation with high resolution is a prerequisite in refined research of dolomite. Here, we reported the multielement imaging results of a lacustrine dolomite nodule with the host black shale from the Songliao Basin, northeast of China. Micro X-ray fluorescence (μ-XRF) with a spatial resolution down to 10 μm was used for in situ scanning. Two key parameter settings of the μ-XRF, including single-point exposure time and spatial resolution, were optimized to achieve a better result in a reasonable scanning time scale. The final imaging data graphically revealed dynamic variation of elemental distributions, including elements enriched in dolomite (e.g., Ca, Mg, Fe, and Mn), clastic quartz (Si), and clay minerals (e.g., Al and K) and redox-sensitive trace elements (e.g., Cr, Mo, V, and U). The well-preserved laminated structures inside the nodule and the features with a magnesium-rich core wrapped with an iron-concentric outer layer and a manganese-concentric shell together indicated its primary form as dolomite and a gradual transformation into ankerite as well as manganese-ankerite. The elemental variation indicates a varied bottom water redox condition, which involved from sulfidic to ferruginous and manganous zones. Here, we propose that the intermittent supplies of sulfate and Fe-/Mn-oxidized minerals interrupting the black shale deposition while favoring dolomitization might be brought by the oxidized and salted seawater. And this lacustrine dolomite is expected to be a potential fingerprint mineral in tracking the seawater intrusions to the Songliao Basin which happened 91 million years ago.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2022/9019061
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 4
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    Online Resource
    Association of P2Y12 Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients
    Hindawi Limited ; 2014
    In:  BioMed Research International Vol. 2014 ( 2014), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-8
    Abstract: Background . Clopidogrel inhibits the ADP receptor P2Y12 to keep down the platelet aggregation. The goal of our study is to investigate the contribution of P2Y12 promoter DNA methylation to the risk of clopidogrel resistance (CR). Methods . The platelet functions were measured by the VerifyNow P2Y12 assay. Applying the bisulfite pyrosequencing technology, DNA methylation levels of two CpG dinucleotides on P2Y12 promoter were tested among 49 CR cases and 57 non-CR controls. We also investigated the association among P2Y12 DNA methylation, various biochemical characteristics, and CR. Result . Lower methylation of two CpGs indicated the poorer clopidogrel response (CpG1, P = 0.009 ; CpG2, P = 0.022 ) in alcohol abusing status. Meanwhile CpG1 methylation was inversely correlated with CR in smoking patients ( P = 0.026 ) and in subgroup of Albumin 〈 35 ( P = 0.002 ). We observed that the level of DNA methylation might be affected by some clinical markers, such as TBIL, LEVF, Albumin, AST. The results also showed that the quantity of stent, fasting blood-glucose, and lower HbAC1 were the predictors of CR. Conclusions . The evidence from our study indicates that P2Y12 methylation may bring new hints to elaborate the pathogenesis of CR.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2014/450814
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2698540-8
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  • 5
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    Online Resource
    Identifying the Geographical Origin of Tobacco Leaf by Strontium and Lead Isotopic with Mineral Elemental Fingerprint
    Hindawi Limited ; 2022
    In:  International Journal of Chemical Engineering Vol. 2022 ( 2022-6-21), p. 1-10
    Details
    In: International Journal of Chemical Engineering, Hindawi Limited, Vol. 2022 ( 2022-6-21), p. 1-10
    Abstract: The primary aim of this paper was to identifying the geographical origin of tobacco leaves based on stable isotopic and mineral elemental fingerprint. We collected eighty-one tobacco leaf samples from Argentina, Brazil, Zimbabwe, the U.S., Zambia, and China. And nine mineral element contents and four strontium and lead isotope ratios of the tobacco leaves were determined by thermal ionization mass spectrometry (TIMS) and inductively coupled plasma mass spectrometry (ICP-MS). After variance and stepwise discriminant analysis, the discriminant functions of the tobacco leaf’s geographical origin were established. The results indicate that: (1) the contents of six mineral elements including Cu, Zn, Cr, Ni, Cd, and Pb, together with four strontium and lead isotope ratios containing 87Sr/86Sr, 208Pb/204Pb, 207Pb/204Pb, and 206Pb/204Pb, were significantly different among six countries. (2) Different countries presented some characteristic mineral elemental and isotopic fingerprint. The even contents of mineral elements from Zambian tobacco leaf were much lower than the other countries, among which four elements consisting of Zn, Cr, As, and Cd were not detected. The three average lead isotope ratios including 208Pb/204Pb, 207Pb/204Pb, and 206Pb/204Pb from Zimbabwe tobacco leaves were far higher than the other countries, and the range of which was unoverlapped. (3) The effective identification of the geographical origin of tobacco leaf was accomplished by Fisher stepwise discriminant analysis and the characteristic tracing elements consisted of Cu, Zn, Cr, Ni, Cd, Pb, 87Sr/86Sr, 207Pb/204Pb, and 206Pb/204Pb. Based on the established discriminant functions, the original and cross-validation accuracy towards different geographical origins of tobacco leaves were 98.8% and 95.1%, respectively. The study shows that the strontium and lead isotopic with mineral elemental fingerprints is a potential effective method to identify the geographical origin of tobacco leaves from different countries.
    Type of Medium: Online Resource
    ISSN: 1687-8078 , 1687-806X
    URL: Article
    DOI: 10.1155/2022/5949770
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2448899-9
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  • 6
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    Online Resource
    Seismic Response Analysis of an Isolated Structure with QZS under Near-Fault Vertical Earthquakes
    Hindawi Limited ; 2018
    In:  Shock and Vibration Vol. 2018 ( 2018), p. 1-12
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2018 ( 2018), p. 1-12
    Abstract: Seismic isolation devices are usually designed to protect structures from the strong horizontal component of earthquake ground shaking. However, the effect of near-fault (NF) vertical ground motions on seismic responses of buildings has become an important consideration due to the observed building damage caused by vertical excitation. As the structure needs to maintain its load bearing capacity, using the horizontal isolation strategy in vertical seismic isolation will lead to the problem of larger static displacement. In particular, the bearings may generate large deformation responses of isolators for NF vertical ground motions. A seismic isolation system including quasi-zero stiffness (QZS) and vertical damper (VD) is used to control NF vertical earthquakes. The characteristics of vertical seismic isolated structures incorporating QZS and VD are presented. The formula for the maximum bearing capacity of QZS isolation considering the stiffness of vertical spring components is obtained by theoretical derivation. From the static analysis, it is found that the static capacity of the QZS isolation system with vertical seismic isolation components increases when the configurative parameter reduces. Seismic response analyses of the seismic isolated structure model with QZS and VD subjected to NF vertical earthquakes are conducted. The results show that seismic responses of the structure can be controlled by setting the appropriate static equilibrium position, vertical isolation period, and vertical damping ratio. Adding a damping ratio is effective in controlling the vertical large deformation of the isolator.
    Type of Medium: Online Resource
    ISSN: 1070-9622 , 1875-9203
    URL: Article
    DOI: 10.1155/2018/9149721
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2070162-7
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  • 7
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    Online Resource
    Novel PGC-1α/ATF5 Axis Partly Activates UPRmt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-12-26), p. 1-21
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-12-26), p. 1-21
    Abstract: Mitochondrial unfolding protein response (UPRmt) effectively resists the pathological cardiac hypertrophy and improves the mitochondrial function. However, the specific activation mechanism and drugs that can effectively activate UPRmt in the cardiac muscle are yet to be elucidated. The aim of this study was to determine the regulation role of UPRmt on preventing pathological cardiac hypertrophy by tetrahydrocurcumin (THC) and explore its underlying molecular mechanism. Male C57BL/6J wild-type (WT) mice were divided into a control group and subjected to sham treatment for 4 weeks, and a test group which was subjected to transverse aortic constriction (TAC) surgery. Animals in the control and test group were orally administered THC (50 mg/kg) for 4 weeks after TAC procedure; an equivalent amount of saline was orally administered in the control sham-treated group and the TAC group. Subsequently, oxidative stress and UPRmt markers were assessed in these mice, and cardiac hypertrophy, fibrosis, and cardiac function were tested. Small interfering RNA (siRNA) targeting proliferator-activated receptor-gamma coactivator (PGC)-1α and activating transcription factor 5 (ATF5) were used to determine the UPRmt activation mechanism. THC supplement partly upregulated UPRmt effectors and inhibited TAC-induced oxidative stress compared with TAC-operated WT mice, thereby substantially attenuating contractile dysfunction, cardiac hypertrophy, and fibrosis. Furthermore, PGC-1α knockdown blunted the UPRmt activation and the cardioprotective role of THC. The interaction between PGC-1α and ATF5 was tested in neonatal rat cardiac myocytes under normal conditions. The results showed that PGC-1α was an upstream effector of ATF5 and partly activated UPRmt. In vitro, phenylephrine- (PE-) induced cardiomyocyte hypertrophy caused ATF5 upregulating rather than downregulating corresponding to the downregulation of PGC-1α. The PGC-1α/ATF5 axis mediated the UPRmt activation and stress-resistance role of THC in vitro. Collectively, the present study provides the first evidence that PGC-1 and ATF5 can form a signaling axis to partly activate UPRmt that mediates the cardioprotective role of THC in pathological cardiac hypertrophy.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2020/9187065
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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  • 8
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    Online Resource
    Prognostic Value of Admission Mean Corpuscular Volume for Major Adverse Cardiovascular Events following Stent Implantation in Nondiabetic and Diabetic Patients with Acute Coronary Syndrome
    Hindawi Limited ; 2020
    In:  Disease Markers Vol. 2020 ( 2020-07-18), p. 1-12
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2020 ( 2020-07-18), p. 1-12
    Abstract: Background. One of the key concerns of the clinician is to identify and manage risk factors for major adverse cardiovascular events (MACEs) in nondiabetic and diabetic patients with acute coronary syndrome (ACS) undergoing stent implantation. Mean corpuscular volume (MCV) is a marker of erythrocyte size and activity and is associated with prognosis of cardiovascular disease. However, the role of admission MCV in predicting MACEs following stent implantation in diabetes mellitus (DM), non-DM, or whole patients with ACS remains largely unknown. Methods and Results. A total of 437 ACS patients undergoing stent implantation, including 294 non-DM ( 59.08 ± 10.24 years) and 143 DM ( 63.02 ± 9.92 years), were analyzed. Admission MCV was higher in non-DM than DM patients. During a median of 31.93 months follow-up, Kaplan-Meier curve demonstrated that higher admission MCV level was significantly associated with increased MACEs in whole and non-DM, but not in DM patients. In Cox regression analysis, the highest MCV tertile was associated with higher MACEs in whole ([HR] 1.870, 95% CI 1.113-3.144, P = 0.018 ), especially those non-DM ([HR] 2.089, 95% CI 1.077-4.501, P = 0.029 ) patients after adjustment of several cardiovascular risk factors. MCV did not predict MACEs in DM patients. During landmark analysis, admission MCV showed better predictive value for MACEs in the first 32 months of follow-up than in the subsequent period. Finally, the receiver operating characteristic (ROC) curve was conducted to confirmed the value of admission MCV within 32 months. Conclusion. In patients with ACS, elevated admission MCV is an important and independent predictor for MACEs following stent implantation, especially amongst those without DM even after adjusting for lifestyle and clinical risk factors. However, as the follow-up period increased, the admission MCV lost its ability to predict MACEs.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2020/7054596
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033253-1
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  • 9
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    Online Resource
    GO Loss: A Gaussian Distribution-Based Orthogonal Decomposition Loss for Classification
    Hindawi Limited ; 2019
    In:  Complexity Vol. 2019 ( 2019-12-12), p. 1-10
    Details
    In: Complexity, Hindawi Limited, Vol. 2019 ( 2019-12-12), p. 1-10
    Abstract: We present a novel loss function, namely, GO loss, for classification. Most of the existing methods, such as center loss and contrastive loss, dynamically determine the convergence direction of the sample features during the training process. By contrast, GO loss decomposes the convergence direction into two mutually orthogonal components, namely, tangential and radial directions, and conducts optimization on them separately. The two components theoretically affect the interclass separation and the intraclass compactness of the distribution of the sample features, respectively. Thus, separately minimizing losses on them can avoid the effects of their optimization. Accordingly, a stable convergence center can be obtained for each of them. Moreover, we assume that the two components follow Gaussian distribution, which is proved as an effective way to accurately model training features for improving the classification effects. Experiments on multiple classification benchmarks, such as MNIST, CIFAR, and ImageNet, demonstrate the effectiveness of GO loss.
    Type of Medium: Online Resource
    ISSN: 1076-2787 , 1099-0526
    URL: Article
    DOI: 10.1155/2019/9206053
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2004607-8
    SSG: 11
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  • 10
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    Online Resource
    Industrial Image Enhancement Method Based on Cloud Edge Fusion
    Hindawi Limited ; 2022
    In:  Wireless Communications and Mobile Computing Vol. 2022 ( 2022-5-6), p. 1-11
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2022 ( 2022-5-6), p. 1-11
    Abstract: Aiming at the problems of high mean square error, low peak signal-to-noise ratio, and long enhancement time of traditional industrial image enhancement methods, an industrial image enhancement method based on cloud edge fusion was proposed. Firstly, the industrial image is preprocessed and denoised by median filtering algorithm to detect the edge of denoised image. Then, the image is enhanced by top hat transform. Finally, the cloud edge fusion method is used to complete the task of industrial image enhancement to improve the efficiency of industrial image enhancement. The experimental results show that the mean square error of this method is kept at a low level, the peak signal-to-noise ratio is always above 53 dB, and the average industrial image enhancement time is 0.96 s. This method has good performance and can obtain a good industrial image enhancement effect, which has certain application value.
    Type of Medium: Online Resource
    ISSN: 1530-8677 , 1530-8669
    URL: Article
    DOI: 10.1155/2022/7717161
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045240-8
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