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  • Online Resource  (4)
  • Future Medicine Ltd  (4)
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  • Online Resource  (4)
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  • Future Medicine Ltd  (4)
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  • 1
    Online Resource
    Online Resource
    Future Medicine Ltd ; 2010
    In:  Future Oncology Vol. 6, No. 11 ( 2010-11), p. 1691-1710
    In: Future Oncology, Future Medicine Ltd, Vol. 6, No. 11 ( 2010-11), p. 1691-1710
    Abstract: The field of gene therapy for malignant glioma has made important advances since the first gene transfer studies were performed 20 years ago. Multiple Phase I/II trials and two Phase III trials have been performed and have demonstrated the feasibility and safety of intratumoral vector delivery in the brain. Sitimagene ceradenovec is an adenoviral vector encoding the herpes simplex thymidine kinase gene, developed by Ark Therapeutics Group plc (UK and Finland) for the treatment of patients with operable high-grade glioma. In preclinical and Phase I/II clinical studies, sitimagene ceradenovec exhibited a significant increase in survival. Although the preliminary results of a Phase III clinical study demonstrated a significant positive effect of sitimagene ceradenovec treatment on time to reintervention or death when compared with standard care treatment (hazard ratio: 1.43; 95% CI: 1.06–1.93; p 〈 0.05), the European Committee for Medicinal Products for Human Use did not consider the data to provide sufficient evidence of clinical benefit. Further clinical evaluation, powered to demonstrate a benefit on a robust end point, is required. This article focuses on sitimagene ceradenovec and provides an overview of the developments in the field of gene therapy for malignant glioma.
    Type of Medium: Online Resource
    ISSN: 1479-6694 , 1744-8301
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2010
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  • 2
    Online Resource
    Online Resource
    Future Medicine Ltd ; 2012
    In:  CNS Oncology Vol. 1, No. 1 ( 2012-09), p. 25-27
    In: CNS Oncology, Future Medicine Ltd, Vol. 1, No. 1 ( 2012-09), p. 25-27
    Abstract: Martin J van den Bent is trained as a neurologist. Since 1992, he has worked at the Neuro-Oncology Unit of Erasmus MC – Daniel den Hoed Cancer Center in Rotterdam, The Netherlands. In 2002 he became the head of the Neuro-Oncology Unit, which is focused on the treatment of primary brain tumors and on neurological complications of cancer and its treatment. He is currently Professor of Neuro-Oncology at Erasmus University, Rotterdam. He has been the principle investigator of a large number of international multicenter trials on both high- and low-grade glial tumors, most of which were conducted through the European Organisation for Research and Treatment of Cancer Brain Tumor Group. Many of these trials included translational research projects, focusing on the identification of prognostic and predictive molecular parameters of outcomes of treatment. He was Secretary of the European Organisation for Research and Treatment of Cancer Brain Tumor Group from 1996 to 2002 and from 2002 to 2009 he was Chair of this internationally recognized group. He has served as Chairman of the CNS section of the 14th European Cancer Conference and of the Dutch Neuro-Oncology Working Group. He has published widely, not only on the treatment of primary brain tumors, but also on neurological complications of systemic cancers. He has chaired and lectured at numerous national and international educational symposia and scientific meetings on neuro-oncology and serves on the editorial board of several oncology journals, including CNS Oncology. He has written chapters in many textbooks on neuro-oncology and is active in the Response Assessment in Neuro-Oncology Group revising the end points and response criteria of trials in neuro-oncology.
    Type of Medium: Online Resource
    ISSN: 2045-0907 , 2045-0915
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2012
    detail.hit.zdb_id: 2692808-5
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  • 3
    Online Resource
    Online Resource
    Future Medicine Ltd ; 2015
    In:  CNS Oncology Vol. 4, No. 3 ( 2015-05), p. 179-192
    In: CNS Oncology, Future Medicine Ltd, Vol. 4, No. 3 ( 2015-05), p. 179-192
    Abstract: SUMMARY  The treatment of glial brain tumors begins with surgery, and standard adjuvant treatment at the end of the past millennium for high-grade glioma and high-risk low-grade glioma was radiotherapy and chemotherapy was given at recurrence. However, over the past 10 years much has changed regarding the role of chemotherapy in gliomas and it is now clear that chemotherapy has a role in the treatment of almost all newly diagnosed diffuse gliomas (WHO grade II–IV). This is the result of several prospective studies that showed survival benefit after combined chemoradiotherapy with temozolomide in glioblastoma (WHO grade IV) or after procarbazine, CCNU (lomustine) and vincristine chemotherapy in diffuse low-grade (WHO grade II) and anaplastic (WHO grade III) glioma. The current standard of treatment for diffuse gliomas is described in this overview and in addition some attention is given to targeted therapies.
    Type of Medium: Online Resource
    ISSN: 2045-0907 , 2045-0915
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2015
    detail.hit.zdb_id: 2692808-5
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  • 4
    Online Resource
    Online Resource
    Future Medicine Ltd ; 2015
    In:  CNS Oncology Vol. 4, No. 5 ( 2015-10), p. 281-285
    In: CNS Oncology, Future Medicine Ltd, Vol. 4, No. 5 ( 2015-10), p. 281-285
    Type of Medium: Online Resource
    ISSN: 2045-0907 , 2045-0915
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2015
    detail.hit.zdb_id: 2692808-5
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