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  • Online Resource  (4)
  • Frontiers Media SA  (4)
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  • Online Resource  (4)
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  • Frontiers Media SA  (4)
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  • 1
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2021-7-2)
    Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that causes high rates of disability and mortality worldwide because of severe progressive and irreversible symptoms. During the period of COPD initiation and progression, the immune system triggers the activation of various immune cells, including Regulatory T cells (Tregs), dendritic cells (DCs) and Th17 cells, and also the release of many different cytokines and chemokines, such as IL-17A and TGF-β. In recent years, studies have focused on the role of IL-17A in chronic inflammation process, which was found to play a highly critical role in facilitating COPD. Specially, IL-17A and its downstream regulators are potential therapeutic targets for COPD. We mainly focused on the possibility of IL-17A signaling pathways that involved in the progression of COPD; for instance, how IL-17A promotes airway remodeling in COPD? How IL-17A facilitates neutrophil inflammation in COPD? How IL-17A induces the expression of TSLP to promote the progression of COPD? Whether the mature DCs and Tregs participate in this process and how they cooperate with IL-17A to accelerate the development of COPD? And above associated studies could benefit clinical application of therapeutic targets of the disease. Moreover, four novel efficient therapies targeting IL-17A and other molecules for COPD are also concluded, such as Bufei Yishen formula (BYF), a Traditional Chinese Medicine (TCM), and curcumin, a natural polyphenol extracted from the root of Curcuma longa .
    Type of Medium: Online Resource
    ISSN: 1663-9812
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Frontiers Media SA ; 2018
    In:  Frontiers in Human Neuroscience Vol. 12 ( 2018-10-15)
    In: Frontiers in Human Neuroscience, Frontiers Media SA, Vol. 12 ( 2018-10-15)
    Type of Medium: Online Resource
    ISSN: 1662-5161
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2018
    detail.hit.zdb_id: 2425477-0
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  • 3
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 10 ( 2022-2-4)
    Abstract: Helium-bearing gas is accumulated in the Lower Ordovician, Upper Carboniferous, and Lower Permian reservoirs of the Daniudi gas field in Ordos Basin, and the helium concentrations and isotopic compositions are investigated in order to reveal the abundance and origin of helium. Geochemical characteristics indicate that the natural gas from the Daniudi gas field has helium concentrations of 0.0271–0.1273%, with R/Ra ratios of 0.007–0.072. The 4 He/ 20 Ne ratios range from 848 to 17,000, which are substantially higher than the ratio of air or air saturated water. The proved helium reserves of the Daniudi gas field exceed 100 × 10 6  m 3 , suggesting an extra-large helium gas field. Helium in the field is of crustal origin and derived from the radioactive decay of U and Th in the rocks and minerals, with no significant contribution by atmospheric or mantle-derived helium. The natural gas in the Daniudi gas field displays the characteristics of typical crustal helium, which is consistent with the gases from cratonic basins (Ordos, Sichuan, and Tarim) in China, whereas the gases from rift basins (Songliao, Bohai Bay, and Subei) have experienced a significant addition of mantle-derived helium.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2741235-0
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  • 4
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 10 ( 2022-2-24)
    Abstract: The Dongpu Sag is one of the important areas for oil and gas exploration in the Bohai Bay Basin, eastern China, and natural gas from different strata in the sag contain a certain amount of helium, with the geochemical characteristics and the implications being weakly studied. Based on the analyses of the helium contents and isotopic ratios ( 3 He/ 4 He, 40 Ar/ 36 Ar, CH 4 / 3 He, and CO 2 / 3 He) of natural gas, the abundance and origin of helium as well as the correlation with CH 4 and CO 2 are investigated. The results indicate that, natural gas samples from the Dongpu Sag display the helium contents of 0.0031–0.0217% and 3 He/ 4 He ratios of 0.148 × 10 −7 –11.986 × 10 –7 , and the CH 4 / 3 He and CO 2 / 3 He ratios range from 3.7 × 10 9 to 1.8263 × 10 12 and from 0.05×10 9 to 35.04 × 10 9 , respectively. Natural gas in the sag is helium depleted and extremely depleted, with the average helium content of 0.0133%. The helium reserves in the total gas reserves are 18.38 × 10 6  m 3 , meeting the standard of small helium gas field. The helium is mainly crustal which has been mixed by a small amount of mantle-derived helium, whose proportion ranges from 0.01% to 10.72% with an average of 2.39%. Helium-related isotopic ratios of natural gas from the Dongpu Sag are consistent with those from other areas of the Bohai Bay Basin, suggesting crust-mantle mixed sources. Several gas samples from members 2 and 3 of the Shahejie Fm. contain an insignificant amount of mantle-derived helium, displaying the characteristics consistent with natural gas from typical cratonic basins.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2741235-0
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