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  • Frontiers Media SA  (27)
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  • 1
    Online Resource
    Online Resource
    DataSheet1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Bioengineering and Biotechnology Vol. 10 ( 2022-7-8)
    Details
    In: Frontiers in Bioengineering and Biotechnology, Frontiers Media SA, Vol. 10 ( 2022-7-8)
    Abstract: Zika virus (ZIKV) is a re-emerging flavivirus that leads to devastating consequences for fetal development. It is crucial to visualize the pathogenicity activities of ZIKV ranging from infection pathways to immunity processes, but the accurate labeling of ZIKV remains challenging due to the lack of a reliable labeling technique. We introduce the photo-activated bio-orthogonal cycloaddition to construct a fluorogenic probe for the labeling and visualizing of ZIKV. Via a simple UV photoirradiation, the fluorogenic probes could be effectively labeled on the ZIKV. We demonstrated that it can be used for investigating the interaction between ZIKV and diverse cells and avoiding the autofluorescence phenomenon in traditional immunofluorescence assay. Thus, this bioorthogonal-enabled labeling strategy can serve as a promising approach to monitor and understand the interaction between the ZIKV and host cells.
    Type of Medium: Online Resource
    ISSN: 2296-4185
    URL: Article
    URL: Article
    DOI: 10.3389/fbioe.2022.940511
    DOI: 10.3389/fbioe.2022.940511.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2719493-0
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  • 2
    Online Resource
    Online Resource
    DataSheet_1.zip
    Frontiers Media SA ; 2020
    In:  Frontiers in Pharmacology Vol. 11 ( 2020-8-28)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 11 ( 2020-8-28)
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2020.565461
    DOI: 10.3389/fphar.2020.565461.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 3
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    Depression and Anxiety Among Quarantined People, Community Workers, Medical Staff, and General Population in the Early Stage of COVID-19 Epidemic
    Frontiers Media SA ; 2021
    In:  Frontiers in Psychology Vol. 12 ( 2021-3-26)
    Details
    In: Frontiers in Psychology, Frontiers Media SA, Vol. 12 ( 2021-3-26)
    Abstract: Background: We described the prevalence of anxiety and depression related to COVID-19 pandemic among different types of population and examined their potential risk factors. Methods: A cross-sectional survey was conducted to collect demographic characteristics, exposure histories, and many other concerns about COVID-19. The Zung's self-rating anxiety scale (SAS) and self-rating depression scale (SDS), followed by a four-step multiple logistic regression analysis was performed to identify factors associated with mental health outcomes. Results: Out of 3,303 participants, the quarantined people (40.9%), community workstation staffs-policemen-volunteers (CPV) (36.4%) and general public (30.7%) reported higher percentages of depression than the general medical staff (18.4%). Moreover, the quarantined people (19.1%) also showed higher prevalence of anxiety than the general public (9.1%) and the general medical staff (7.8%). The quarantined people had the highest risk of anxiety and depression, whereas the self-rated health was negatively associated with the risks of anxiety and depression. Younger age group (18 to 30 years) showed higher risks of anxiety (OR = 6.22, 95% CI = 2.89–13.38, p & lt; 0.001) and depression (OR = 3.69, 95% CI = 2.40–5.69, p & lt; 0.001). People who had exposure history or contact from Hubei province after December 1, 2019 (OR = 1.57, 95% CI = 1.07–2.30, p & lt; 0.001), had family or friends engaged in front-line health care work (OR = 1.47, 95% CI = 1.02–2.14, p & lt; 0.001), had confirmed case nearby (OR = 2.44, 95% CI = 1.43–4.18, p & lt; 0.001) were all more likely to suffer from anxiety. Moreover, the negligence (OR = 1.85, 95% CI = 1.37–2.51, p & lt; 0.001) or overindulgence (OR = 1.45, 95% CI = 1.03–2.04, p & lt; 0.001) toward the epidemic information was associated with a higher risk of depression and anxiety. Conclusions: Our findings show that the CPV and quarantined people were most at-risk population. We have identified that the young people, people with exposure histories and negligence or overindulgence toward epidemic information are in grave need of attention.
    Type of Medium: Online Resource
    ISSN: 1664-1078
    URL: Article
    DOI: 10.3389/fpsyg.2021.638985
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2563826-9
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  • 4
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    Image1.PNG
    Frontiers Media SA ; 2022
    In:  Frontiers in Physics Vol. 10 ( 2022-6-20)
    Details
    In: Frontiers in Physics, Frontiers Media SA, Vol. 10 ( 2022-6-20)
    Abstract: Self-oscillation and bifurcation as many-body dynamics solutions in a high-Q microresonator have induced substantial interest in nonlinear optics and ultrafast science. Strong mode coupling between clockwise (CW) wave and counterclockwise (CCW) wave induces mode-splitting and optical self-oscillation in the optical cavity. This study experimentally demonstrates the self-oscillation microcomb formation in a microresonator with strong backward Rayleigh scattering. When a pump laser sweeps across a resonance, both spontaneous symmetry breaking (SSB) and self-oscillation phenomenon are observed. The breathing soliton and stable soliton state can switch to each other through careful tuning of the pump detuning. Our experiments provide a reliable scheme for breather soliton microcomb generation. Meanwhile, the rich physics process enhances the comprehension of nonlinear optics in a cavity.
    Type of Medium: Online Resource
    ISSN: 2296-424X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fphy.2022.908141
    DOI: 10.3389/fphy.2022.908141.s001
    DOI: 10.3389/fphy.2022.908141.s002
    DOI: 10.3389/fphy.2022.908141.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2721033-9
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  • 5
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    Image1.PNG
    Frontiers Media SA ; 2023
    In:  Frontiers in Cell and Developmental Biology Vol. 11 ( 2023-4-3)
    Details
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 11 ( 2023-4-3)
    Abstract: Introduction: Hepatocellular carcinoma (HCC) patients may benefit from chemotherapy, but drug resistance is an important obstacle to favorable prognoses. Overcoming drug resistance is an urgent problem to be solved. Methods: Differential expression analysis was used to identify long non-coding RNAs (LncRNAs) that differed in chemotherapy-sensitive and chemotherapy-resistant patients. Machine learning algorithms including random forest (RF), lasso regression (LR), and support vector machines (SVMs) were used to identify important chemotherapy-related LncRNAs. A back propagation (BP) network was then used to validate the predictive capacity of important LncRNAs. The molecular functions of hub LncRNAs were investigated via qRT-PCR and cell proliferation assay. Molecular-docking technique was used to explore candidate drug of targets of hub LncRNA in the model. Results: A total of 125 differentially expressed LncRNAs between sensitive and resistant patients. Seventeen important LncRNAs were identified via RF, and seven factors were identified via LR. With respect to SVM, the top 15 LncRNAs of AvgRank were selected. Five merge chemotherapy-related LncRNAs were used to predict chemotherapy resistance with high accuracy. CAHM was a hub LncRNA of model and expression high in sorafenib resistance cell lines. In addition, the results of CCK8 showed that the sensitivity of HepG2-sorafenib cells to sorafenib was significantly lower than that of HepG2; and the sensitivity of HepG2-sorafenib cells transfected with sh-CAHM was significantly higher than that of Sorafenib. In the non-transfection group, the results of clone formation experiments showed that the number of clones formed by HepG2-sorafenib cells treated with sorafenib was significantly more than that of HepG2; after HepG2-sorafenib cells were transfected with sh-CAHM, the number of clones formed by Sorafenib treatment was significantly higher than that of HepG2 cells. The number was significantly less than that of HepG2-s + sh-NC group. Molecular Docking results indicate that Moschus was candidate drug for target protein of CAHM. Conclusion: Five chemotherapy-related LncRNAs could predict drug resistance in HCC with high accuracy, and the hub LncRNA CAHM has potential as a new biomarker for HCC chemotherapy resistance.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    URL: Article
    URL: Article
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    URL: Article
    DOI: 10.3389/fcell.2023.1174183
    DOI: 10.3389/fcell.2023.1174183.s001
    DOI: 10.3389/fcell.2023.1174183.s002
    DOI: 10.3389/fcell.2023.1174183.s003
    DOI: 10.3389/fcell.2023.1174183.s004
    DOI: 10.3389/fcell.2023.1174183.s005
    DOI: 10.3389/fcell.2023.1174183.s006
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2737824-X
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  • 6
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    Dynamic optimization of open-pit coal mine production scheduling based on ARIMA and fuzzy structured element
    Frontiers Media SA ; 2023
    In:  Frontiers in Earth Science Vol. 10 ( 2023-1-13)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 10 ( 2023-1-13)
    Abstract: A dynamic optimization method was created to address the production schedule issue in an open-pit coal mine while taking into account the characteristics of the fuzzy structured element. The fuzzy mining capacities of all “geologically optimal push-back bodies” were then examined using the moving cove method. One of the most crucial elements in the process of open-pit coal mine production scheduling optimization is coal pricing. As a result, this work also presents a dynamic optimization technique for production scheduling that incorporates the prediction of economic time series and the generation of dynamic economic indices. An appropriate time series model is created to forecast the future coal price based on previous data on coal prices. The prediction results are used in the calculation of optimal mining body generation to dynamically obtain the optimal production scheduling model. The Baorixile Open-pit Coal Mine in China’s Inner Mongolia Autonomous Region is using this method. The Autoregressive Integrated Moving Average Model ARIMA is constructed to anticipate the coal price in the future 23 years by evaluating and processing the coal price from 2009 to 2022, and the ideal production scheduling scheme of the mine economics is afterwards identified. The ideal fuzzy coal mining volume, the potential production life, and the fuzzy total net present value ( NPV ) of the annual production scheduling are all provided at the same time. The optimization findings can better give fundamental support for mine design and future production since the fuzzy problem is accurately expressed by correct formulations.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    DOI: 10.3389/feart.2022.1040464
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741235-0
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  • 7
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    Stackelberg game-based three-stage optimal pricing and planning strategy for hybrid shared energy storage
    Frontiers Media SA ; 2023
    In:  Frontiers in Energy Research Vol. 11 ( 2023-9-19)
    Details
    In: Frontiers in Energy Research, Frontiers Media SA, Vol. 11 ( 2023-9-19)
    Abstract: Inspired from sharing economy and advanced energy storage technologies, hybrid shared energy storage (HSES), as an innovative business model, can provide flexible storage leasing services to new energy stations (NESs) and bring additional profits to the energy storage owner. Under this business model, pricing and planning issues are the main focus of the HSES operator to increase revenues but are rarely considered in current studies. Therefore, a Stackelberg game-based three-stage optimal pricing and planning strategy of HSES is formulated for the operator. First, an HSES model considering two leasing options is developed to provide two kinds of short-term use rights of energy storage resources for NESs. Then, the interactions between selfish NESs and the HSES operator are characterized as a Stackelberg game, and a bi-level pricing and planning strategy optimization model is developed to help the HSES operator make optimal decisions. Finally, considering different characteristics in each stage of the Stackelberg game, a three-stage solution method based on the genetic algorithm (GA) and mixed-integer linear programming (MILP) models is proposed to solve the optimization problem. Case studies on six NESs in a certain region are taken to verify the effectiveness of the proposed strategy. Simulation results show that the HSES operator can obtain maximum profit under the proposed pricing and planning strategy. In addition, the proposed HSES leasing model can provide additional benefits to both the operator and NESs.
    Type of Medium: Online Resource
    ISSN: 2296-598X
    URL: Article
    DOI: 10.3389/fenrg.2023.1273929
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2733788-1
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  • 8
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    Online Resource
    Table_4.XLSX
    Frontiers Media SA ; 2022
    In:  Frontiers in Medicine Vol. 8 ( 2022-2-3)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2022-2-3)
    Abstract: Diabetic kidney disease (DKD) is one of the most serious complications of diabetic patients. Advanced glycation end products (AGEs) induce epithelial-mesenchymal transformation (EMT) of renal tubular epithelial cells (HK-2), resulting in renal tubulointerstitial fibrosis. However, the underlying epigenetic mechanisms remain to be further investigated. In this work, we investigated the functional role of JMJD1A involved in DKD progression. The molecular mechanism study was performed in AGEs-induced HK-2 cells by gene expression analysis, RNA sequencing (RNA-seq), and JMJD1A lentiviral knockdown and overexpression particle transfection. The results showed that AGEs could upregulate JMJD1A, and the expressions of related fibrotic factor were also increased. At the same time, in the DKD animal model induced by unilateral nephrectomy plus streptozotocin (STZ), IHC immunohistochemical staining showed that compared with the control group, the expressions of JMJD1A, FN, and COL1 in the model group were all increased, masson staining results also show that the model group has typical fibrotic changes. This is consistent with the results of our in vitro experiments. In order to determine the downstream pathway, we screened out JMJD1A downstream transcription factors by RNA-seq. Further analysis showed that JMJD1A overexpression could accelerate the progression of AGEs-induced renal fibrosis by reducing the expression of NR4A1 in HK-2 cells. Meanwhile, NR4A1 inhibitor can promote the expression of fibrosis-related factors such as VIM, a-SMA in HK-2 cells, and aggravate the process of fibrosis. Taken together, JMJD1A/NR4A1 signaling can regulate the procession of renal tubular epithelial interstitial fibrosis induced by AGEs in HK-2.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
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    DOI: 10.3389/fmed.2021.807694
    DOI: 10.3389/fmed.2021.807694.s001
    DOI: 10.3389/fmed.2021.807694.s002
    DOI: 10.3389/fmed.2021.807694.s003
    DOI: 10.3389/fmed.2021.807694.s004
    DOI: 10.3389/fmed.2021.807694.s005
    DOI: 10.3389/fmed.2021.807694.s006
    DOI: 10.3389/fmed.2021.807694.s007
    DOI: 10.3389/fmed.2021.807694.s008
    DOI: 10.3389/fmed.2021.807694.s009
    DOI: 10.3389/fmed.2021.807694.s010
    DOI: 10.3389/fmed.2021.807694.s011
    DOI: 10.3389/fmed.2021.807694.s012
    DOI: 10.3389/fmed.2021.807694.s013
    DOI: 10.3389/fmed.2021.807694.s014
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2775999-4
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  • 9
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    Development and Validation of the Breast Cancer Scale QLICP-BR V2.0 Based on Classical Test Theory and Generalizability Theory
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-6-13)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-6-13)
    Abstract: The aim of this study was to develop and validate the breast cancer scale among the system of quality-of-life instruments for cancer patients (QLICP-BR V2.0). Methods Programmed decision procedures and theories on instrument development were applied to develop QLICP-BR V2.0. A total of 246 breast cancer inpatients were investigated using QLICP-BR V2.0 from hospital admission until discharge. The reliability, validity, and responsiveness of the QLICP-BR V2.0 scale were evaluated by using the classical test theory combined with the generalizability theory (GT), including correlation analysis, multi-trait scaling analysis, factor analyses, t -tests, and also multivariate generalizability theory analysis. Results The test–retest reliability of the total scale is 0.79, the Cronbach coefficient is 0.85, and the intra-class correlations coefficient is 0.88. The item–domain correlation analysis showed that the correlation coefficient between items and their own domain is greater than that with other domains except of item GSO4. The exploratory factor analysis showed that three principal components are obtained in the specific module. The outcome of the factor analysis coincides substantially with our theoretical conception. The score difference of each domain of the scale and the total scale before and after treatment is statistically significant ( P & lt; 0.05), with the standardized response mean of the total scale being 0.61. According to GT, the generalization coefficient of the scores in the 5 domains is between 0.626 and 0.768, and the reliability index is between 0.557 and 0.695. Conclusion QLICP-BR V2.0 exhibited reasonable degrees of validity, reliability, and responsiveness according to classical test and the generalizability theory. The number of items in the scale is appropriate.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.915103
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 10
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    Data_Sheet_1.docx
    Frontiers Media SA ; 2020
    In:  Frontiers in Oncology Vol. 10 ( 2020-10-15)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 10 ( 2020-10-15)
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2020.554331
    DOI: 10.3389/fonc.2020.554331.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2649216-7
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