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  • Online Resource  (2)
  • Annual Reviews  (2)
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  • Online Resource  (2)
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  • Annual Reviews  (2)
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  • 1
    Online Resource
    Online Resource
    Cancer-Associated Fibroblasts: Lessons from Pancreatic Cancer
    Annual Reviews ; 2023
    In:  Annual Review of Cancer Biology Vol. 7, No. 1 ( 2023-04-11), p. 43-55
    Details
    In: Annual Review of Cancer Biology, Annual Reviews, Vol. 7, No. 1 ( 2023-04-11), p. 43-55
    Abstract: Cancer-associated fibroblasts (CAFs) are present in all malignancies. Arguably, in none are they as prevalent as they are in pancreatic ductal adenocarcinoma (PDAC), where they often outnumber cancer cells. The origin and function of CAFs are still not completely understood, and attempts to target this cell population as a component of combination therapy have so far not succeeded. Our understanding of pancreatic CAFs is in rapid evolution. Heterogeneity of CAFs is the key concept to understand this cell population. We discuss heterogeneity of origin, with recent findings challenging the notion that CAFs uniformly derive from pancreatic stellate cells, and instead suggesting that multiple types of resident fibroblasts contribute to CAF expansion. Heterogeneity in gene expression divides CAFs in different subpopulations. Most importantly, heterogeneity in function underlies the complexity of CAFs. CAFs deposit components of the extracellular matrix, contributing to the high interstitial pressure in pancreatic cancer. CAFs serve as “feeder” cells for cancer cells by providing metabolites, thus mitigating the effect of the low-nutrient environment of PDAC. At the same time, CAFs regulate the function of the immune system, inhibiting antitumor immune responses. Understanding the functional role of different CAF populations and the drivers of each of their functional roles is key to devising new ways to target this cell population in PDAC.
    Type of Medium: Online Resource
    ISSN: 2472-3428 , 2472-3428
    URL: Issue
    URL: Article
    DOI: 10.1146/cancerbio.2023.7.issue-1
    DOI: 10.1146/annurev-cancerbio-061421-035400
    Language: English
    Publisher: Annual Reviews
    Publication Date: 2023
    detail.hit.zdb_id: 2874401-9
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Epithelial-Stromal Interactions in Pancreatic Cancer
    Annual Reviews ; 2019
    In:  Annual Review of Physiology Vol. 81, No. 1 ( 2019-02-10), p. 211-233
    Details
    In: Annual Review of Physiology, Annual Reviews, Vol. 81, No. 1 ( 2019-02-10), p. 211-233
    Abstract: Pancreatic cancer is characterized by an extensive fibroinflammatory reaction that includes immune cells, fibroblasts, extracellular matrix, vascular and lymphatic vessels, and nerves. Overwhelming evidence indicates that the pancreatic cancer microenvironment regulates cancer initiation, progression, and maintenance. Pancreatic cancer treatment has progressed little over the past several decades, and the prognosis remains one of the worst for any cancer. The contribution of the microenvironment to carcinogenesis is a key area of research, offering new potential targets for treating the disease. Here, we explore the composition of the pancreatic cancer stroma, discuss the network of interactions between different components, and describe recent attempts to target the stroma therapeutically. We also discuss current areas of active research related to the tumor microenvironment.
    Type of Medium: Online Resource
    ISSN: 0066-4278 , 1545-1585
    URL: Issue
    URL: Article
    DOI: 10.1146/physiol.2019.81.issue-1
    DOI: 10.1146/annurev-physiol-020518-114515
    RVK:
    WA 15000
    Language: English
    Publisher: Annual Reviews
    Publication Date: 2019
    detail.hit.zdb_id: 1474465-X
    SSG: 12
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    Online Resource
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