In:
Journal of Endocrinology, Bioscientifica, Vol. 25, No. 3 ( 1962-12), p. 387-396
Abstract:
Lesions were made in the pituitary stalk of rats using a Horsley-Clarke apparatus, and the water metabolism of these rats was investigated after oral administration of tap water or 0·9% NaCl. Diuresis increased temporarily after destruction of the stalk, then an oliguric phase lasting 1 or 2 days developed. Water retention was followed by a more permanent polyuria. During the oliguric phase no diuretic reaction could be induced by oral administration of tap water or physiological saline solution. In that phase water consumption decreased, urine volume diminished with virtually unchanged creatinine excretion, and the specific gravity, sodium, potassium and chloride concentration of the urine increased. Treatment with cortisone, or oral administration of physiological saline or ethanol did not prevent water retention. The oliguric phase was observed only after stalk lesion; hypothalamic lesions distant from the stalk or subcortical lesions had no significant influence on the diuretic reaction. It is suggested that in the development of the oliguric phase, antidiuretic hormone (ADH) released from the hypothalamo-hypophysial system damaged by destruction of the stalk may play a role.
Type of Medium:
Online Resource
ISSN:
0022-0795
,
1479-6805
DOI:
10.1677/joe.0.0250387
Language:
Unknown
Publisher:
Bioscientifica
Publication Date:
1962
detail.hit.zdb_id:
1474892-7
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