In:
Science, American Association for the Advancement of Science (AAAS), Vol. 244, No. 4904 ( 1989-05-05), p. 551-556
Abstract:
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor α (IL-2Rα, p55) chain and the newly identified IL-2 receptor β (IL-2Rβ, p70-75) chain. The cDNA encoding the human IL-2Rβ chain has now been isolated. The overall primary structure of the IL-2Rβ chain shows no apparent homology to other known receptors. Unlike the IL-2Rα chain, the IL-2Rβ chain has a large cytoplasmic region in which a functional domain (or domains) mediating an intracellular signal transduction pathway (or pathways) may be embodied. The cDNA-encoded β chain binds and internalizes IL-2 when expressed on T lymphoid cells but not fibroblast cells. Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2Rα chain cDNA.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.2785715
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
1989
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
SSG:
11
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