In:
Medical Principles and Practice, S. Karger AG, Vol. 13, No. 6 ( 2004), p. 340-345
Abstract:
〈 i 〉 Objective: 〈 /i 〉 To evaluate the effect of desmopressin (DDAVP) on hemostatic parameters during dialysis and in the interval between dialysis sessions. 〈 i 〉 Subjects and Methods: 〈 /i 〉 Fifteen patients dialyzed twice weekly at least for 1 year and 15 healthy volunteers serving as a control group were enrolled in the study. Bleeding time, platelet count, prothrombin time, activated partial thromboplastin time, tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1), euglobulin clot lysis time, protein C, protein S, fibrinogen, D-dimer, factor V, VII, VIII, IX, X and von Willebrand factor (VWF) values were studied at the beginning, at 2 and 4 h of dialysis with and without administration of DDAVP at a dose level of 2 µg/kg intranasally. 〈 i 〉 Results: 〈 /i 〉 After dialysis, bleeding time shortened, PAI-1 and fibrinogen levels were lower, while VWF and D-dimer levels were higher. After DDAVP administration, bleeding time, PAI-1 levels were significantly lower (p 〈 0.01), while tPA, factor VIII and VWF levels increased significantly (p 〈 0.001). 〈 i 〉 Conclusion: 〈 /i 〉 The findings indicate that DDAVP can be used for patients on dialysis with serious bleeding.
Type of Medium:
Online Resource
ISSN:
1011-7571
,
1423-0151
Language:
English
Publisher:
S. Karger AG
Publication Date:
2004
detail.hit.zdb_id:
1482963-0
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